The positive association between the atherogenic index of plasma and the risk of new-onset hypertension: a nationwide cohort study in China
Background The atherogenic index of plasma (AIP) is a novel metabolic biomarker of atherosclerosis. Nevertheless, the association between the AIP and new-onset hypertension has not been elucidated in the Chinese population.Methods Prospective data were obtained from 3150 participants aged ≥ 18 years...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Clinical and Experimental Hypertension |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/10641963.2024.2303999 |
| _version_ | 1826932360205041664 |
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| author | Yue Yuan Jing Shi Wei Sun Xiangqing Kong |
| author_facet | Yue Yuan Jing Shi Wei Sun Xiangqing Kong |
| author_sort | Yue Yuan |
| collection | DOAJ |
| description | Background The atherogenic index of plasma (AIP) is a novel metabolic biomarker of atherosclerosis. Nevertheless, the association between the AIP and new-onset hypertension has not been elucidated in the Chinese population.Methods Prospective data were obtained from 3150 participants aged ≥ 18 years in the China Health and Nutrition Survey from 2009 to 2015. The AIP is a logarithmically transformed ratio of triglycerides to high-density lipoprotein cholesterol in molar concentration. Cox regression analysis was used to determine the association of AIP index with new-onset hypertension.Results After the six-year follow-up, 1054 (33.4%) participants developed new-onset hypertension. The participants were divided into AIP quartile groups (Q1-Q4). Compared with those in Q1, subjects in Q3–4 had nearly 1.35 times the risk of new-onset hypertension after full adjustment [Q3: hazard ratio (HR): 1.35, 95% confidence interval (CI): 1.13–1.62; Q4: HR: 1.35, 95% CI: 1.13–1.64]. The risks of new-onset hypertension were nearly 1.30 times higher in subjects in Q2–4 than in subjects in Q1 (p < .01) after the full adjustment when we excluded subjects with diabetes and/or chronic kidney diseases. There was a significant difference [HR (CI): 1.27 (1.04–1.54) vs. 0.90 (0.69–1.18)] when subjects were divided into two groups according to body mass index (BMI) level (<24 vs. ≥24 kg/m2).Conclusions The present study suggested that individuals with a higher AIP index are associated with new-onset hypertension, independent of kidney function and glucose levels. The association was stronger in subjects with normal BMI, which may provide early screening of metabolomics in hypertension prevention. |
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| issn | 1064-1963 1525-6006 |
| language | English |
| last_indexed | 2025-02-17T17:12:59Z |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Clinical and Experimental Hypertension |
| spelling | doaj.art-6393e75662b042abab11688ba966a5e82024-12-16T03:46:05ZengTaylor & Francis GroupClinical and Experimental Hypertension1064-19631525-60062024-12-0146110.1080/10641963.2024.2303999The positive association between the atherogenic index of plasma and the risk of new-onset hypertension: a nationwide cohort study in ChinaYue Yuan0Jing Shi1Wei Sun2Xiangqing Kong3Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, People’s Republic of ChinaDepartment of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, People’s Republic of ChinaDepartment of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, People’s Republic of ChinaDepartment of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, People’s Republic of ChinaBackground The atherogenic index of plasma (AIP) is a novel metabolic biomarker of atherosclerosis. Nevertheless, the association between the AIP and new-onset hypertension has not been elucidated in the Chinese population.Methods Prospective data were obtained from 3150 participants aged ≥ 18 years in the China Health and Nutrition Survey from 2009 to 2015. The AIP is a logarithmically transformed ratio of triglycerides to high-density lipoprotein cholesterol in molar concentration. Cox regression analysis was used to determine the association of AIP index with new-onset hypertension.Results After the six-year follow-up, 1054 (33.4%) participants developed new-onset hypertension. The participants were divided into AIP quartile groups (Q1-Q4). Compared with those in Q1, subjects in Q3–4 had nearly 1.35 times the risk of new-onset hypertension after full adjustment [Q3: hazard ratio (HR): 1.35, 95% confidence interval (CI): 1.13–1.62; Q4: HR: 1.35, 95% CI: 1.13–1.64]. The risks of new-onset hypertension were nearly 1.30 times higher in subjects in Q2–4 than in subjects in Q1 (p < .01) after the full adjustment when we excluded subjects with diabetes and/or chronic kidney diseases. There was a significant difference [HR (CI): 1.27 (1.04–1.54) vs. 0.90 (0.69–1.18)] when subjects were divided into two groups according to body mass index (BMI) level (<24 vs. ≥24 kg/m2).Conclusions The present study suggested that individuals with a higher AIP index are associated with new-onset hypertension, independent of kidney function and glucose levels. The association was stronger in subjects with normal BMI, which may provide early screening of metabolomics in hypertension prevention.https://www.tandfonline.com/doi/10.1080/10641963.2024.2303999Blood pressureatherogenic index of plasmatriglyceridescohort studieshigh-density lipoprotein-cholesterol |
| spellingShingle | Yue Yuan Jing Shi Wei Sun Xiangqing Kong The positive association between the atherogenic index of plasma and the risk of new-onset hypertension: a nationwide cohort study in China Clinical and Experimental Hypertension Blood pressure atherogenic index of plasma triglycerides cohort studies high-density lipoprotein-cholesterol |
| title | The positive association between the atherogenic index of plasma and the risk of new-onset hypertension: a nationwide cohort study in China |
| title_full | The positive association between the atherogenic index of plasma and the risk of new-onset hypertension: a nationwide cohort study in China |
| title_fullStr | The positive association between the atherogenic index of plasma and the risk of new-onset hypertension: a nationwide cohort study in China |
| title_full_unstemmed | The positive association between the atherogenic index of plasma and the risk of new-onset hypertension: a nationwide cohort study in China |
| title_short | The positive association between the atherogenic index of plasma and the risk of new-onset hypertension: a nationwide cohort study in China |
| title_sort | positive association between the atherogenic index of plasma and the risk of new onset hypertension a nationwide cohort study in china |
| topic | Blood pressure atherogenic index of plasma triglycerides cohort studies high-density lipoprotein-cholesterol |
| url | https://www.tandfonline.com/doi/10.1080/10641963.2024.2303999 |
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