Impact of Human FcγR Gene Polymorphisms on IgG-Triggered Cytokine Release: Critical Importance of Cell Assay Format

Impact of Human FcγR Gene Polymorphisms on IgG-Triggered Cytokine Release: Critical Importance of Cell Assay Format

Monoclonal antibody (mAb) immunotherapy has transformed the treatment of allergy, autoimmunity, and cancer. The interaction of mAb with Fc gamma receptors (FcγR) is often critical for efficacy. The genes encoding the low-affinity FcγR have single nucleotide polymorphisms (SNPs) and copy number varia...

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Bibliographic Details
Main Authors: Khiyam Hussain, Chantal E. Hargreaves, Tania F. Rowley, Joshua M. Sopp, Kate V. Latham, Pallavi Bhatta, John Sherington, Rona M. Cutler, David P. Humphreys, Martin J. Glennie, Jonathan C. Strefford, Mark S. Cragg
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Immunology
Subjects:
Fc gamma receptors
antibody immunotherapy
Fc gamma receptor polymorphism
cytokine release syndrome
cytokine release assays
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00390/full

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