Diagnostic and therapeutic strategies in cryptococcosis: impact on outcome
Cryptococcosis diagnosis has been recently improved by the use of rapid cryptococcal antigen testing with lateral flow assays, which have proved sensitive and specific. Using “test and treat” screening strategies for cryptococcal disease with these tests has been showed effective in reducing cryptoc...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2018-05-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762018000700207&lng=en&tlng=en |
| _version_ | 1797756574151737344 |
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| author | Timothée Boyer Chammard Elvis Temfack Olivier Lortholary Alexandre Alanio |
| author_facet | Timothée Boyer Chammard Elvis Temfack Olivier Lortholary Alexandre Alanio |
| author_sort | Timothée Boyer Chammard |
| collection | DOAJ |
| description | Cryptococcosis diagnosis has been recently improved by the use of rapid cryptococcal antigen testing with lateral flow assays, which have proved sensitive and specific. Using “test and treat” screening strategies for cryptococcal disease with these tests has been showed effective in reducing cryptococcal meningitis (CM) in HIV-infected patients. Recommended induction, consolidation, and maintenance therapeutic strategy for CM is widely unavailable and/or expensive in low and middle-income settings. New therapeutic strategies, mostly using reduced duration, have recently shown acceptable outcome or are currently tested. Diagnostic and therapeutic guidelines for cryptococcal disease in limited resources countries are undergoing a paradigmatic shift. |
| first_indexed | 2024-03-12T18:03:29Z |
| format | Article |
| id | doaj.art-63962c62a8df4f26aa2d85345b9da026 |
| institution | Directory Open Access Journal |
| issn | 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T18:03:29Z |
| publishDate | 2018-05-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-63962c62a8df4f26aa2d85345b9da0262023-08-02T09:32:23ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz1678-80602018-05-01113710.1590/0074-02760180050S0074-02762018000700207Diagnostic and therapeutic strategies in cryptococcosis: impact on outcomeTimothée Boyer ChammardElvis TemfackOlivier LortholaryAlexandre AlanioCryptococcosis diagnosis has been recently improved by the use of rapid cryptococcal antigen testing with lateral flow assays, which have proved sensitive and specific. Using “test and treat” screening strategies for cryptococcal disease with these tests has been showed effective in reducing cryptococcal meningitis (CM) in HIV-infected patients. Recommended induction, consolidation, and maintenance therapeutic strategy for CM is widely unavailable and/or expensive in low and middle-income settings. New therapeutic strategies, mostly using reduced duration, have recently shown acceptable outcome or are currently tested. Diagnostic and therapeutic guidelines for cryptococcal disease in limited resources countries are undergoing a paradigmatic shift.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762018000700207&lng=en&tlng=enCryptococcus neoformanscryptococcal meningo-encephalitiscryptococcal antigenHIV infectionadvanced AIDS diseasescreening |
| spellingShingle | Timothée Boyer Chammard Elvis Temfack Olivier Lortholary Alexandre Alanio Diagnostic and therapeutic strategies in cryptococcosis: impact on outcome Memorias do Instituto Oswaldo Cruz Cryptococcus neoformans cryptococcal meningo-encephalitis cryptococcal antigen HIV infection advanced AIDS disease screening |
| title | Diagnostic and therapeutic strategies in cryptococcosis: impact on outcome |
| title_full | Diagnostic and therapeutic strategies in cryptococcosis: impact on outcome |
| title_fullStr | Diagnostic and therapeutic strategies in cryptococcosis: impact on outcome |
| title_full_unstemmed | Diagnostic and therapeutic strategies in cryptococcosis: impact on outcome |
| title_short | Diagnostic and therapeutic strategies in cryptococcosis: impact on outcome |
| title_sort | diagnostic and therapeutic strategies in cryptococcosis impact on outcome |
| topic | Cryptococcus neoformans cryptococcal meningo-encephalitis cryptococcal antigen HIV infection advanced AIDS disease screening |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762018000700207&lng=en&tlng=en |
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