A chemical toolbox for the study of bromodomains and epigenetic signaling
Bromodomains are conserved protein interaction modules that recognize acetyl-lysine modifications. Here the authors present a set of 25 selective small molecule inhibitors covering 29 human bromodomain targets and comprehensively evaluate the selectivity of this probe-set.
Bibliographic Details
| Main Authors: |
Qin Wu,
David Heidenreich,
Stanley Zhou,
Suzanne Ackloo,
Andreas Krämer,
Kiran Nakka,
Evelyne Lima-Fernandes,
Genevieve Deblois,
Shili Duan,
Ravi N. Vellanki,
Fengling Li,
Masoud Vedadi,
Jeffrey Dilworth,
Mathieu Lupien,
Paul E. Brennan,
Cheryl H. Arrowsmith,
Susanne Müller,
Oleg Fedorov,
Panagis Filippakopoulos,
Stefan Knapp |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2019-04-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-019-09672-2
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