Targeting Protein Kinase C for Cancer Therapy
Protein kinase C (PKC) isoforms, a group of serine-threonine kinases, are important regulators in carcinogenesis. Numerous studies have demonstrated that PKC isoforms exert both positive and negative effects on cancer cell demise. In this review, we systematically summarize the current findings on t...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/14/5/1104 |
| _version_ | 1797475545325240320 |
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| author | Sijia He Qi Li Qian Huang Jin Cheng |
| author_facet | Sijia He Qi Li Qian Huang Jin Cheng |
| author_sort | Sijia He |
| collection | DOAJ |
| description | Protein kinase C (PKC) isoforms, a group of serine-threonine kinases, are important regulators in carcinogenesis. Numerous studies have demonstrated that PKC isoforms exert both positive and negative effects on cancer cell demise. In this review, we systematically summarize the current findings on the architecture, activity regulation and biological functions of PKCs, especially their relationship with anti-cancer therapy-induced cell death. Additionally, we elaborate on current knowledge of the effects of PKCs on tumor metabolism and microenvironment, which have gained increasing attention in oncology-related areas. Furthermore, we underscore the basic experimental and clinical implications of PKCs as a target for cancer therapy to evaluate their therapeutic benefits and potential applications. |
| first_indexed | 2024-03-09T20:45:39Z |
| format | Article |
| id | doaj.art-6396f16e6a4c427da0d3d8cee12c7c11 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T20:45:39Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-6396f16e6a4c427da0d3d8cee12c7c112023-11-23T22:45:56ZengMDPI AGCancers2072-66942022-02-01145110410.3390/cancers14051104Targeting Protein Kinase C for Cancer TherapySijia He0Qi Li1Qian Huang2Jin Cheng3Cancer Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, ChinaCancer Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, ChinaCancer Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, ChinaCancer Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, ChinaProtein kinase C (PKC) isoforms, a group of serine-threonine kinases, are important regulators in carcinogenesis. Numerous studies have demonstrated that PKC isoforms exert both positive and negative effects on cancer cell demise. In this review, we systematically summarize the current findings on the architecture, activity regulation and biological functions of PKCs, especially their relationship with anti-cancer therapy-induced cell death. Additionally, we elaborate on current knowledge of the effects of PKCs on tumor metabolism and microenvironment, which have gained increasing attention in oncology-related areas. Furthermore, we underscore the basic experimental and clinical implications of PKCs as a target for cancer therapy to evaluate their therapeutic benefits and potential applications.https://www.mdpi.com/2072-6694/14/5/1104protein kinase Ccancercell deathtargeted therapy |
| spellingShingle | Sijia He Qi Li Qian Huang Jin Cheng Targeting Protein Kinase C for Cancer Therapy Cancers protein kinase C cancer cell death targeted therapy |
| title | Targeting Protein Kinase C for Cancer Therapy |
| title_full | Targeting Protein Kinase C for Cancer Therapy |
| title_fullStr | Targeting Protein Kinase C for Cancer Therapy |
| title_full_unstemmed | Targeting Protein Kinase C for Cancer Therapy |
| title_short | Targeting Protein Kinase C for Cancer Therapy |
| title_sort | targeting protein kinase c for cancer therapy |
| topic | protein kinase C cancer cell death targeted therapy |
| url | https://www.mdpi.com/2072-6694/14/5/1104 |
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