Hepatic <i>Nfe2l2</i> Is Not an Essential Mediator of the Metabolic Phenotype Produced by Dietary Methionine Restriction

Hepatic <i>Nfe2l2</i> Is Not an Essential Mediator of the Metabolic Phenotype Produced by Dietary Methionine Restriction

The principal sensing of dietary methionine restriction (MR) occurs in the liver, where it activates multiple transcriptional programs that mediate various biological components of the response. Hepatic <i>Fgf21</i> is a key target and essential endocrine mediator of the metabolic phenot...

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Bibliographic Details
Main Authors: Han Fang, Kirsten P. Stone, Sujoy Ghosh, Laura A. Forney, Landon C. Sims, LeighAnn Vincik, Thomas W. Gettys
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Nutrients
Subjects:
essential amino acid
nutrient sensing
obesity
integrated stress response
Nfe2l2
FGF21
Online Access:https://www.mdpi.com/2072-6643/13/6/1788

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