Functions of Matricellular Proteins in Dental Tissues and Their Emerging Roles in Orofacial Tissue Development, Maintenance, and Disease
Matricellular proteins (MCPs) are defined as extracellular matrix (ECM) associated proteins that are important regulators and integrators of microenvironmental signals, contributing to the dynamic nature of ECM signalling. There is a growing understanding of the role of matricellular proteins in cel...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/12/6626 |
| _version_ | 1797529355227758592 |
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| author | Georgia Nikoloudaki |
| author_facet | Georgia Nikoloudaki |
| author_sort | Georgia Nikoloudaki |
| collection | DOAJ |
| description | Matricellular proteins (MCPs) are defined as extracellular matrix (ECM) associated proteins that are important regulators and integrators of microenvironmental signals, contributing to the dynamic nature of ECM signalling. There is a growing understanding of the role of matricellular proteins in cellular processes governing tissue development as well as in disease pathogenesis. In this review, the expression and functions of different MP family members (periostin, CCNs, TSPs, SIBLINGs and others) are presented, specifically in relation to craniofacial development and the maintenance of orofacial tissues, including bone, gingiva, oral mucosa, palate and the dental pulp. As will be discussed, each MP family member has been shown to have non-redundant roles in development, tissue homeostasis, wound healing, pathology and tumorigenesis of orofacial and dental tissues. |
| first_indexed | 2024-03-10T10:12:39Z |
| format | Article |
| id | doaj.art-6397a39984e147dea734a6b02cfa3079 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T10:12:39Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-6397a39984e147dea734a6b02cfa30792023-11-22T01:01:59ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-06-012212662610.3390/ijms22126626Functions of Matricellular Proteins in Dental Tissues and Their Emerging Roles in Orofacial Tissue Development, Maintenance, and DiseaseGeorgia Nikoloudaki0Schulich Dentistry Department, Schulich School of Medicine and Dentistry, Western University, London, ON N6A 5C1, CanadaMatricellular proteins (MCPs) are defined as extracellular matrix (ECM) associated proteins that are important regulators and integrators of microenvironmental signals, contributing to the dynamic nature of ECM signalling. There is a growing understanding of the role of matricellular proteins in cellular processes governing tissue development as well as in disease pathogenesis. In this review, the expression and functions of different MP family members (periostin, CCNs, TSPs, SIBLINGs and others) are presented, specifically in relation to craniofacial development and the maintenance of orofacial tissues, including bone, gingiva, oral mucosa, palate and the dental pulp. As will be discussed, each MP family member has been shown to have non-redundant roles in development, tissue homeostasis, wound healing, pathology and tumorigenesis of orofacial and dental tissues.https://www.mdpi.com/1422-0067/22/12/6626matricellular proteinsperiostinSPARCSIBLINGsDSPPDMP1 |
| spellingShingle | Georgia Nikoloudaki Functions of Matricellular Proteins in Dental Tissues and Their Emerging Roles in Orofacial Tissue Development, Maintenance, and Disease International Journal of Molecular Sciences matricellular proteins periostin SPARC SIBLINGs DSPP DMP1 |
| title | Functions of Matricellular Proteins in Dental Tissues and Their Emerging Roles in Orofacial Tissue Development, Maintenance, and Disease |
| title_full | Functions of Matricellular Proteins in Dental Tissues and Their Emerging Roles in Orofacial Tissue Development, Maintenance, and Disease |
| title_fullStr | Functions of Matricellular Proteins in Dental Tissues and Their Emerging Roles in Orofacial Tissue Development, Maintenance, and Disease |
| title_full_unstemmed | Functions of Matricellular Proteins in Dental Tissues and Their Emerging Roles in Orofacial Tissue Development, Maintenance, and Disease |
| title_short | Functions of Matricellular Proteins in Dental Tissues and Their Emerging Roles in Orofacial Tissue Development, Maintenance, and Disease |
| title_sort | functions of matricellular proteins in dental tissues and their emerging roles in orofacial tissue development maintenance and disease |
| topic | matricellular proteins periostin SPARC SIBLINGs DSPP DMP1 |
| url | https://www.mdpi.com/1422-0067/22/12/6626 |
| work_keys_str_mv | AT georgianikoloudaki functionsofmatricellularproteinsindentaltissuesandtheiremergingrolesinorofacialtissuedevelopmentmaintenanceanddisease |