Treading a HOSTile path: Mapping the dynamic landscape of host cell–rotavirus interactions to explore novel host-directed curative dimensions
Viruses are intracellular pathogens and are dependent on host cellular resources to carry out their cycles of perpetuation. Obtaining an integrative view of host–virus interaction is of utmost importance to understand the complex and dynamic interplay between viral components and host machineries. B...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2021-12-01
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| Series: | Virulence |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/21505594.2021.1903198 |
| _version_ | 1798014835504447488 |
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| author | Upayan Patra Urbi Mukhopadhyay Arpita Mukherjee Shanta Dutta Mamta Chawla-Sarkar |
| author_facet | Upayan Patra Urbi Mukhopadhyay Arpita Mukherjee Shanta Dutta Mamta Chawla-Sarkar |
| author_sort | Upayan Patra |
| collection | DOAJ |
| description | Viruses are intracellular pathogens and are dependent on host cellular resources to carry out their cycles of perpetuation. Obtaining an integrative view of host–virus interaction is of utmost importance to understand the complex and dynamic interplay between viral components and host machineries. Besides its obvious scholarly significance, a comprehensive host–virus interaction profile also provides a platform where from host determinants of pro-viral and antiviral importance can be identified and further be subjected to therapeutic intervention. Therefore, adjunct to conventional methods of prophylactic vaccination and virus-directed antivirals, this host-targeted antiviral approach holds promising therapeutic potential. In this review, we present a comprehensive landscape of host cellular reprogramming in response to infection with rotavirus (RV) which causes profuse watery diarrhea in neonates and infants. In addition, an emphasis is given on how host determinants are either usurped or subverted by RV in course of infection and how therapeutic manipulation of specific host factors can effectively modulate the RV life cycle. |
| first_indexed | 2024-04-11T15:24:43Z |
| format | Article |
| id | doaj.art-63981e7446044de8b2aa95ef4451ca01 |
| institution | Directory Open Access Journal |
| issn | 2150-5594 2150-5608 |
| language | English |
| last_indexed | 2024-04-11T15:24:43Z |
| publishDate | 2021-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Virulence |
| spelling | doaj.art-63981e7446044de8b2aa95ef4451ca012022-12-22T04:16:18ZengTaylor & Francis GroupVirulence2150-55942150-56082021-12-011211022106210.1080/21505594.2021.19031981903198Treading a HOSTile path: Mapping the dynamic landscape of host cell–rotavirus interactions to explore novel host-directed curative dimensionsUpayan Patra0Urbi Mukhopadhyay1Arpita Mukherjee2Shanta Dutta3Mamta Chawla-Sarkar4National Institute of Cholera and Enteric DiseasesNational Institute of Cholera and Enteric DiseasesNational Institute of Cholera and Enteric DiseasesNational Institute of Cholera and Enteric DiseasesNational Institute of Cholera and Enteric DiseasesViruses are intracellular pathogens and are dependent on host cellular resources to carry out their cycles of perpetuation. Obtaining an integrative view of host–virus interaction is of utmost importance to understand the complex and dynamic interplay between viral components and host machineries. Besides its obvious scholarly significance, a comprehensive host–virus interaction profile also provides a platform where from host determinants of pro-viral and antiviral importance can be identified and further be subjected to therapeutic intervention. Therefore, adjunct to conventional methods of prophylactic vaccination and virus-directed antivirals, this host-targeted antiviral approach holds promising therapeutic potential. In this review, we present a comprehensive landscape of host cellular reprogramming in response to infection with rotavirus (RV) which causes profuse watery diarrhea in neonates and infants. In addition, an emphasis is given on how host determinants are either usurped or subverted by RV in course of infection and how therapeutic manipulation of specific host factors can effectively modulate the RV life cycle.http://dx.doi.org/10.1080/21505594.2021.1903198rotavirushost–virus interactionspro-viral and antiviral host determinantshost-directed antivirals |
| spellingShingle | Upayan Patra Urbi Mukhopadhyay Arpita Mukherjee Shanta Dutta Mamta Chawla-Sarkar Treading a HOSTile path: Mapping the dynamic landscape of host cell–rotavirus interactions to explore novel host-directed curative dimensions Virulence rotavirus host–virus interactions pro-viral and antiviral host determinants host-directed antivirals |
| title | Treading a HOSTile path: Mapping the dynamic landscape of host cell–rotavirus interactions to explore novel host-directed curative dimensions |
| title_full | Treading a HOSTile path: Mapping the dynamic landscape of host cell–rotavirus interactions to explore novel host-directed curative dimensions |
| title_fullStr | Treading a HOSTile path: Mapping the dynamic landscape of host cell–rotavirus interactions to explore novel host-directed curative dimensions |
| title_full_unstemmed | Treading a HOSTile path: Mapping the dynamic landscape of host cell–rotavirus interactions to explore novel host-directed curative dimensions |
| title_short | Treading a HOSTile path: Mapping the dynamic landscape of host cell–rotavirus interactions to explore novel host-directed curative dimensions |
| title_sort | treading a hostile path mapping the dynamic landscape of host cell rotavirus interactions to explore novel host directed curative dimensions |
| topic | rotavirus host–virus interactions pro-viral and antiviral host determinants host-directed antivirals |
| url | http://dx.doi.org/10.1080/21505594.2021.1903198 |
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