An efficient metal-free and catalyst-free C–S/C–O bond-formation strategy: synthesis of pyrazole-conjugated thioamides and amides

An efficient metal-free and catalyst-free C–S/C–O bond-formation strategy: synthesis of pyrazole-conjugated thioamides and amides

An operationally simple and metal-free approach is described for the synthesis of pyrazole-tethered thioamide and amide conjugates. The thioamides were generated by employing a three-component reaction of diverse pyrazole C-3/4/5 carbaldehydes, secondary amines, and elemental sulfur in a single synt...

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Bibliographic Details
Main Authors: Shubham Sharma, Dharmender Singh, Sunit Kumar, Vaishali, Rahul Jamra, Naveen Banyal, Deepika, Chandi C. Malakar, Virender Singh
Format: Article
Language:English
Published: Beilstein-Institut 2023-03-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
c–s/o bond formation
metal-free
oxidative amidation
pyrazole carbaldehydes
sulfur insertion
thioamides
Online Access:https://doi.org/10.3762/bjoc.19.22

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