The Role of Inflammasomes in Glomerulonephritis
The inflammasome is an immune multiprotein complex that activates pro-caspase 1 in response to inflammation-inducing stimuli and it leads to IL-1β and IL-18 proinflammatory cytokine production. NLRP1 and NLRP3 inflammasomes are the best characterized and they have been related to several autoimmune...
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| Format: | Article |
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MDPI AG
2022-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/8/4208 |
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| author | Paula Anton-Pampols Clara Diaz-Requena Laura Martinez-Valenzuela Francisco Gomez-Preciado Xavier Fulladosa Anna Vidal-Alabro Joan Torras Núria Lloberas Juliana Draibe |
| author_facet | Paula Anton-Pampols Clara Diaz-Requena Laura Martinez-Valenzuela Francisco Gomez-Preciado Xavier Fulladosa Anna Vidal-Alabro Joan Torras Núria Lloberas Juliana Draibe |
| author_sort | Paula Anton-Pampols |
| collection | DOAJ |
| description | The inflammasome is an immune multiprotein complex that activates pro-caspase 1 in response to inflammation-inducing stimuli and it leads to IL-1β and IL-18 proinflammatory cytokine production. NLRP1 and NLRP3 inflammasomes are the best characterized and they have been related to several autoimmune diseases. It is well known that the kidney expresses inflammasome genes, which can influence the development of some glomerulonephritis, such as lupus nephritis, ANCA glomerulonephritis, IgA nephropathy and anti-GBM nephropathy. Polymorphisms of these genes have also been described to play a role in autoimmune and kidney diseases. In this review, we describe the main characteristics, activation mechanisms, regulation and functions of the different inflammasomes. Moreover, we discuss the latest findings about the role of the inflammasome in several glomerulonephritis from three different points of view: in vitro, animal and human studies. |
| first_indexed | 2024-03-09T10:34:04Z |
| format | Article |
| id | doaj.art-639e1af2b7554e4292d7c57e4b2cbdf6 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T10:34:04Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-639e1af2b7554e4292d7c57e4b2cbdf62023-12-01T21:02:57ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-04-01238420810.3390/ijms23084208The Role of Inflammasomes in GlomerulonephritisPaula Anton-Pampols0Clara Diaz-Requena1Laura Martinez-Valenzuela2Francisco Gomez-Preciado3Xavier Fulladosa4Anna Vidal-Alabro5Joan Torras6Núria Lloberas7Juliana Draibe8Nephrology Department, Bellvitge University Hospital, Hospitalet de Llobregat, 08907 Barcelona, SpainIDIBELL Biomedical Research Institute, Hospitalet de Llobregat, 08907 Barcelona, SpainNephrology Department, Bellvitge University Hospital, Hospitalet de Llobregat, 08907 Barcelona, SpainNephrology Department, Bellvitge University Hospital, Hospitalet de Llobregat, 08907 Barcelona, SpainNephrology Department, Bellvitge University Hospital, Hospitalet de Llobregat, 08907 Barcelona, SpainIDIBELL Biomedical Research Institute, Hospitalet de Llobregat, 08907 Barcelona, SpainNephrology Department, Bellvitge University Hospital, Hospitalet de Llobregat, 08907 Barcelona, SpainIDIBELL Biomedical Research Institute, Hospitalet de Llobregat, 08907 Barcelona, SpainNephrology Department, Bellvitge University Hospital, Hospitalet de Llobregat, 08907 Barcelona, SpainThe inflammasome is an immune multiprotein complex that activates pro-caspase 1 in response to inflammation-inducing stimuli and it leads to IL-1β and IL-18 proinflammatory cytokine production. NLRP1 and NLRP3 inflammasomes are the best characterized and they have been related to several autoimmune diseases. It is well known that the kidney expresses inflammasome genes, which can influence the development of some glomerulonephritis, such as lupus nephritis, ANCA glomerulonephritis, IgA nephropathy and anti-GBM nephropathy. Polymorphisms of these genes have also been described to play a role in autoimmune and kidney diseases. In this review, we describe the main characteristics, activation mechanisms, regulation and functions of the different inflammasomes. Moreover, we discuss the latest findings about the role of the inflammasome in several glomerulonephritis from three different points of view: in vitro, animal and human studies.https://www.mdpi.com/1422-0067/23/8/4208inflammasomeNLRP3glomerulonephritisinnate immunity |
| spellingShingle | Paula Anton-Pampols Clara Diaz-Requena Laura Martinez-Valenzuela Francisco Gomez-Preciado Xavier Fulladosa Anna Vidal-Alabro Joan Torras Núria Lloberas Juliana Draibe The Role of Inflammasomes in Glomerulonephritis International Journal of Molecular Sciences inflammasome NLRP3 glomerulonephritis innate immunity |
| title | The Role of Inflammasomes in Glomerulonephritis |
| title_full | The Role of Inflammasomes in Glomerulonephritis |
| title_fullStr | The Role of Inflammasomes in Glomerulonephritis |
| title_full_unstemmed | The Role of Inflammasomes in Glomerulonephritis |
| title_short | The Role of Inflammasomes in Glomerulonephritis |
| title_sort | role of inflammasomes in glomerulonephritis |
| topic | inflammasome NLRP3 glomerulonephritis innate immunity |
| url | https://www.mdpi.com/1422-0067/23/8/4208 |
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