Paroxysmal nocturnal hemoglobinuria in a patient post COVID‐19 virus infection: A case report with literature review
Abstract COVID 19 is a serious infection that originated in Wuhan, China and has resulted in worldwide morbidity and mortality. It continues to be a major health concern in 2022, being associated with multiorgan failure. Although the pathophysiology of the disease and its complications are not well...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-10-01
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| Series: | Clinical Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ccr3.8011 |
| _version_ | 1797650413572325376 |
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| author | Mohammed Albalawi Turki Alwasaidi Mohammed Almohammadi Ashraf Ahmad Alzarief Ghaleb Elyamany |
| author_facet | Mohammed Albalawi Turki Alwasaidi Mohammed Almohammadi Ashraf Ahmad Alzarief Ghaleb Elyamany |
| author_sort | Mohammed Albalawi |
| collection | DOAJ |
| description | Abstract COVID 19 is a serious infection that originated in Wuhan, China and has resulted in worldwide morbidity and mortality. It continues to be a major health concern in 2022, being associated with multiorgan failure. Although the pathophysiology of the disease and its complications are not well understood, it is believed that a cytokine storm, triggered by complement activation may be responsible for the severity and complications of the disease. As of now, there is no definitive treatment available. Hematological changes associated with COVID‐19 include lymphopenia, anemia, thrombocytopenia, disseminated intravascular coagulopathy, and thrombosis. Paroxysmal nocturnal hemoglobinuria (PNH), on the other hand, is an acquired clonal hematopoietic stem cell disorder that occurs due to an acquired PIG‐A mutation affecting the hematopoietic stem cells. Interestingly, PNH exhibits some clinical and laboratory manifestations like those seen in COVID‐19. In this report, we present a rare case of PNH that developed following a COVID‐19 infection. |
| first_indexed | 2024-03-11T15:59:50Z |
| format | Article |
| id | doaj.art-639f129367c946d8902cb8da213ddea2 |
| institution | Directory Open Access Journal |
| issn | 2050-0904 |
| language | English |
| last_indexed | 2024-03-11T15:59:50Z |
| publishDate | 2023-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical Case Reports |
| spelling | doaj.art-639f129367c946d8902cb8da213ddea22023-10-25T07:12:44ZengWileyClinical Case Reports2050-09042023-10-011110n/an/a10.1002/ccr3.8011Paroxysmal nocturnal hemoglobinuria in a patient post COVID‐19 virus infection: A case report with literature reviewMohammed Albalawi0Turki Alwasaidi1Mohammed Almohammadi2Ashraf Ahmad Alzarief3Ghaleb Elyamany4Department of Internal Medicine, College of Medicine Taibah University Madinah Saudi ArabiaDepartment of Internal Medicine, College of Medicine Taibah University Madinah Saudi ArabiaKing Abdullah International Medical Research Center King Saud bin Abdulaziz University for Health Sciences, Pathology and Laboratory Medicine, King Abdulaziz Medical City Jeddah Saudi ArabiaDepartment of Neurosurgery Cairo University Cairo EgyptCentral Military Laboratory and Blood Bank Prince Sultan Military Medical City Riyadh Saudi ArabiaAbstract COVID 19 is a serious infection that originated in Wuhan, China and has resulted in worldwide morbidity and mortality. It continues to be a major health concern in 2022, being associated with multiorgan failure. Although the pathophysiology of the disease and its complications are not well understood, it is believed that a cytokine storm, triggered by complement activation may be responsible for the severity and complications of the disease. As of now, there is no definitive treatment available. Hematological changes associated with COVID‐19 include lymphopenia, anemia, thrombocytopenia, disseminated intravascular coagulopathy, and thrombosis. Paroxysmal nocturnal hemoglobinuria (PNH), on the other hand, is an acquired clonal hematopoietic stem cell disorder that occurs due to an acquired PIG‐A mutation affecting the hematopoietic stem cells. Interestingly, PNH exhibits some clinical and laboratory manifestations like those seen in COVID‐19. In this report, we present a rare case of PNH that developed following a COVID‐19 infection.https://doi.org/10.1002/ccr3.8011ComplementsCOVID‐19PNH |
| spellingShingle | Mohammed Albalawi Turki Alwasaidi Mohammed Almohammadi Ashraf Ahmad Alzarief Ghaleb Elyamany Paroxysmal nocturnal hemoglobinuria in a patient post COVID‐19 virus infection: A case report with literature review Clinical Case Reports Complements COVID‐19 PNH |
| title | Paroxysmal nocturnal hemoglobinuria in a patient post COVID‐19 virus infection: A case report with literature review |
| title_full | Paroxysmal nocturnal hemoglobinuria in a patient post COVID‐19 virus infection: A case report with literature review |
| title_fullStr | Paroxysmal nocturnal hemoglobinuria in a patient post COVID‐19 virus infection: A case report with literature review |
| title_full_unstemmed | Paroxysmal nocturnal hemoglobinuria in a patient post COVID‐19 virus infection: A case report with literature review |
| title_short | Paroxysmal nocturnal hemoglobinuria in a patient post COVID‐19 virus infection: A case report with literature review |
| title_sort | paroxysmal nocturnal hemoglobinuria in a patient post covid 19 virus infection a case report with literature review |
| topic | Complements COVID‐19 PNH |
| url | https://doi.org/10.1002/ccr3.8011 |
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