Non-Alcoholic Steatohepatitis (NASH): Risk Factors in Morbidly Obese Patients
The aim was to investigate the prevalence of non-alcoholic steatohepatitis (NASH) and risk factors for hepatic fibrosis in morbidly obese patients submitted to bariatric surgery. This retrospective study recruited all patients submitted to bariatric surgery from January 2007 to December 2012 at a re...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2015-10-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1422-0067/16/10/25552 |
| _version_ | 1811201681652711424 |
|---|---|
| author | Alexandre Losekann Antonio C. Weston Angelo A. de Mattos Cristiane V. Tovo Luis A. de Carli Marilia B. Espindola Sergio R. Pioner Gabriela P. Coral |
| author_facet | Alexandre Losekann Antonio C. Weston Angelo A. de Mattos Cristiane V. Tovo Luis A. de Carli Marilia B. Espindola Sergio R. Pioner Gabriela P. Coral |
| author_sort | Alexandre Losekann |
| collection | DOAJ |
| description | The aim was to investigate the prevalence of non-alcoholic steatohepatitis (NASH) and risk factors for hepatic fibrosis in morbidly obese patients submitted to bariatric surgery. This retrospective study recruited all patients submitted to bariatric surgery from January 2007 to December 2012 at a reference attendance center of Southern Brazil. Clinical and biochemical data were studied as a function of the histological findings of liver biopsies done during the surgery. Steatosis was present in 226 (90.4%) and NASH in 176 (70.4%) cases. The diagnosis of cirrhosis was established in four cases (1.6%) and fibrosis in 108 (43.2%). Risk factors associated with NASH at multivariate analysis were alanine aminotransferase (ALT) >1.5 times the upper limit of normal (ULN); glucose ≥ 126 mg/dL and triglycerides ≥ 150 mg/dL. All patients with ALT ≥1.5 times the ULN had NASH. When the presence of fibrosis was analyzed, ALT > 1.5 times the ULN and triglycerides ≥ 150 mg/dL were risk factors, furthermore, there was an increase of 1% in the prevalence of fibrosis for each year of age increase. Not only steatosis, but NASH is a frequent finding in MO patients. In the present study, ALT ≥ 1.5 times the ULN identifies all patients with NASH, this finding needs to be further validated in other studies. Moreover, the presence of fibrosis was associated with ALT, triglycerides and age, identifying a subset of patients with more severe disease. |
| first_indexed | 2024-04-12T02:25:34Z |
| format | Article |
| id | doaj.art-639f90c4062a439ca2974449dfe03ac6 |
| institution | Directory Open Access Journal |
| issn | 1422-0067 |
| language | English |
| last_indexed | 2024-04-12T02:25:34Z |
| publishDate | 2015-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-639f90c4062a439ca2974449dfe03ac62022-12-22T03:52:00ZengMDPI AGInternational Journal of Molecular Sciences1422-00672015-10-011610255522555910.3390/ijms161025552ijms161025552Non-Alcoholic Steatohepatitis (NASH): Risk Factors in Morbidly Obese PatientsAlexandre Losekann0Antonio C. Weston1Angelo A. de Mattos2Cristiane V. Tovo3Luis A. de Carli4Marilia B. Espindola5Sergio R. Pioner6Gabriela P. Coral7Post-Graduation Program, Hepatology at Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre 90.050-170, BrasilCentro de Tratamento da Obesidade (CTO), Hospital Santa Casa de Misericórdia de Porto Alegre, Porto Alegre 92.010-300, BrasilPost-Graduation Program, Hepatology at Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre 90.050-170, BrasilPost-Graduation Program, Hepatology at Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre 90.050-170, BrasilCentro de Tratamento da Obesidade (CTO), Hospital Santa Casa de Misericórdia de Porto Alegre, Porto Alegre 92.010-300, BrasilCentro de Tratamento da Obesidade (CTO), Hospital Santa Casa de Misericórdia de Porto Alegre, Porto Alegre 92.010-300, BrasilCentro de Tratamento da Obesidade (CTO), Hospital Santa Casa de Misericórdia de Porto Alegre, Porto Alegre 92.010-300, BrasilPost-Graduation Program, Hepatology at Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre 90.050-170, BrasilThe aim was to investigate the prevalence of non-alcoholic steatohepatitis (NASH) and risk factors for hepatic fibrosis in morbidly obese patients submitted to bariatric surgery. This retrospective study recruited all patients submitted to bariatric surgery from January 2007 to December 2012 at a reference attendance center of Southern Brazil. Clinical and biochemical data were studied as a function of the histological findings of liver biopsies done during the surgery. Steatosis was present in 226 (90.4%) and NASH in 176 (70.4%) cases. The diagnosis of cirrhosis was established in four cases (1.6%) and fibrosis in 108 (43.2%). Risk factors associated with NASH at multivariate analysis were alanine aminotransferase (ALT) >1.5 times the upper limit of normal (ULN); glucose ≥ 126 mg/dL and triglycerides ≥ 150 mg/dL. All patients with ALT ≥1.5 times the ULN had NASH. When the presence of fibrosis was analyzed, ALT > 1.5 times the ULN and triglycerides ≥ 150 mg/dL were risk factors, furthermore, there was an increase of 1% in the prevalence of fibrosis for each year of age increase. Not only steatosis, but NASH is a frequent finding in MO patients. In the present study, ALT ≥ 1.5 times the ULN identifies all patients with NASH, this finding needs to be further validated in other studies. Moreover, the presence of fibrosis was associated with ALT, triglycerides and age, identifying a subset of patients with more severe disease.http://www.mdpi.com/1422-0067/16/10/25552NAFLDNASHmorbidly obeseliver fibrosis |
| spellingShingle | Alexandre Losekann Antonio C. Weston Angelo A. de Mattos Cristiane V. Tovo Luis A. de Carli Marilia B. Espindola Sergio R. Pioner Gabriela P. Coral Non-Alcoholic Steatohepatitis (NASH): Risk Factors in Morbidly Obese Patients International Journal of Molecular Sciences NAFLD NASH morbidly obese liver fibrosis |
| title | Non-Alcoholic Steatohepatitis (NASH): Risk Factors in Morbidly Obese Patients |
| title_full | Non-Alcoholic Steatohepatitis (NASH): Risk Factors in Morbidly Obese Patients |
| title_fullStr | Non-Alcoholic Steatohepatitis (NASH): Risk Factors in Morbidly Obese Patients |
| title_full_unstemmed | Non-Alcoholic Steatohepatitis (NASH): Risk Factors in Morbidly Obese Patients |
| title_short | Non-Alcoholic Steatohepatitis (NASH): Risk Factors in Morbidly Obese Patients |
| title_sort | non alcoholic steatohepatitis nash risk factors in morbidly obese patients |
| topic | NAFLD NASH morbidly obese liver fibrosis |
| url | http://www.mdpi.com/1422-0067/16/10/25552 |
| work_keys_str_mv | AT alexandrelosekann nonalcoholicsteatohepatitisnashriskfactorsinmorbidlyobesepatients AT antoniocweston nonalcoholicsteatohepatitisnashriskfactorsinmorbidlyobesepatients AT angeloademattos nonalcoholicsteatohepatitisnashriskfactorsinmorbidlyobesepatients AT cristianevtovo nonalcoholicsteatohepatitisnashriskfactorsinmorbidlyobesepatients AT luisadecarli nonalcoholicsteatohepatitisnashriskfactorsinmorbidlyobesepatients AT mariliabespindola nonalcoholicsteatohepatitisnashriskfactorsinmorbidlyobesepatients AT sergiorpioner nonalcoholicsteatohepatitisnashriskfactorsinmorbidlyobesepatients AT gabrielapcoral nonalcoholicsteatohepatitisnashriskfactorsinmorbidlyobesepatients |