Akt3 is responsible for the survival and proliferation of embryonic stem cells

Akt3 is responsible for the survival and proliferation of embryonic stem cells

The phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB/Akt) pathway plays an important role in regulating cell proliferation, metabolism, and survival. However, the distinct roles of Akt isoforms (Akt1, Akt2, and Akt3) in pluripotent stem cell maintenance are not fully defined. Using mouse e...

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Bibliographic Details
Main Authors: Ling Wang, Delun Huang, Zongliang Jiang, Yan Luo, Carol Norris, Ming Zhang, Xiuchun Tian, Young Tang
Format: Article
Language:English
Published: The Company of Biologists 2017-06-01
Series:Biology Open
Subjects:
Akt3
Embryonic stem cells
Cell survival
Cell cycle
p53
Online Access:http://bio.biologists.org/content/6/6/850

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