Genetic Predisposition, Fruit Intake and Incident Stroke: A Prospective Chinese Cohort Study
The aim of this study was to evaluate the association between fruit intake and stroke risk considering the genetic predisposition. We used data from 34,871 participants from the project of Prediction for Atherosclerotic Cardiovascular Disease Risk in China (China-PAR project) from 2007 to 2020. A po...
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| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/23/5056 |
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| author | Jun Wang Jianxin Li Fangchao Liu Keyong Huang Xueli Yang Xiaoqing Liu Jie Cao Shufeng Chen Chong Shen Ling Yu Fanghong Lu Liancheng Zhao Ying Li Dongsheng Hu Jianfeng Huang Dongfeng Gu Xiangfeng Lu |
| author_facet | Jun Wang Jianxin Li Fangchao Liu Keyong Huang Xueli Yang Xiaoqing Liu Jie Cao Shufeng Chen Chong Shen Ling Yu Fanghong Lu Liancheng Zhao Ying Li Dongsheng Hu Jianfeng Huang Dongfeng Gu Xiangfeng Lu |
| author_sort | Jun Wang |
| collection | DOAJ |
| description | The aim of this study was to evaluate the association between fruit intake and stroke risk considering the genetic predisposition. We used data from 34,871 participants from the project of Prediction for Atherosclerotic Cardiovascular Disease Risk in China (China-PAR project) from 2007 to 2020. A polygenic risk score comprising 534 genetic variants associated with stroke and its related factors was constructed to categorize individuals into low, intermediate, and high genetic risk groups. The associations of genetic and fruit intake with incident stroke were assessed by the Cox proportional hazard regression. We documented 2586 incident strokes during a median follow-up of 11.2 years. Compared with fruit intake < 200 g/week, similar relative risk reductions in stroke with adherence to fruit intake > 100 g/day across the genetic risk categories were observed (28–32%), but the absolute risk reductions were relatively larger in the highest genetic risk group (<i>p</i> for trend = 0.03). In comparison to those with a fruit intake < 200 g/week, those with a fruit intake >100 g/day in the low, intermediate, and high genetic risk groups had an average of 1.45 (95% CI, 0.61–2.31), 2.12 (1.63–2.59), and 2.19 (1.13–3.22) additional stroke-free years at aged 35, respectively. Our findings suggest that individuals with a high genetic risk could gain more absolute risk reductions and stroke-free years than those with a low genetic risk from increasing fruit intake for the stroke primary prevention. |
| first_indexed | 2024-03-09T17:37:40Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T17:37:40Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-639fb8b9ed494339a9a84ea9ea3907ef2023-11-24T11:51:25ZengMDPI AGNutrients2072-66432022-11-011423505610.3390/nu14235056Genetic Predisposition, Fruit Intake and Incident Stroke: A Prospective Chinese Cohort StudyJun Wang0Jianxin Li1Fangchao Liu2Keyong Huang3Xueli Yang4Xiaoqing Liu5Jie Cao6Shufeng Chen7Chong Shen8Ling Yu9Fanghong Lu10Liancheng Zhao11Ying Li12Dongsheng Hu13Jianfeng Huang14Dongfeng Gu15Xiangfeng Lu16Department of Epidemiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, ChinaDepartment of Epidemiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, ChinaDepartment of Epidemiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, ChinaDepartment of Epidemiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, ChinaTianjin Key Laboratory of Environment, Nutrition and Public Health, Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, Tianjin 300070, ChinaDivision of Epidemiology, Guangdong Provincial People’s Hospital and Cardiovascular Institute, Guangzhou 510080, ChinaDepartment of Epidemiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, ChinaDepartment of Epidemiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, ChinaDepartment of Cardiology, Fujian Provincial Hospital, Fuzhou 350014, ChinaCardio-Cerebrovascular Control and Research Center, Institute of Basic Medicine, Shandong Academy of Medical Sciences, Jinan 250062, ChinaDepartment of Epidemiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, ChinaDepartment of Epidemiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, ChinaDepartment of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou 450001, ChinaDepartment of Epidemiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, ChinaDepartment of Epidemiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, ChinaDepartment of Epidemiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, ChinaThe aim of this study was to evaluate the association between fruit intake and stroke risk considering the genetic predisposition. We used data from 34,871 participants from the project of Prediction for Atherosclerotic Cardiovascular Disease Risk in China (China-PAR project) from 2007 to 2020. A polygenic risk score comprising 534 genetic variants associated with stroke and its related factors was constructed to categorize individuals into low, intermediate, and high genetic risk groups. The associations of genetic and fruit intake with incident stroke were assessed by the Cox proportional hazard regression. We documented 2586 incident strokes during a median follow-up of 11.2 years. Compared with fruit intake < 200 g/week, similar relative risk reductions in stroke with adherence to fruit intake > 100 g/day across the genetic risk categories were observed (28–32%), but the absolute risk reductions were relatively larger in the highest genetic risk group (<i>p</i> for trend = 0.03). In comparison to those with a fruit intake < 200 g/week, those with a fruit intake >100 g/day in the low, intermediate, and high genetic risk groups had an average of 1.45 (95% CI, 0.61–2.31), 2.12 (1.63–2.59), and 2.19 (1.13–3.22) additional stroke-free years at aged 35, respectively. Our findings suggest that individuals with a high genetic risk could gain more absolute risk reductions and stroke-free years than those with a low genetic risk from increasing fruit intake for the stroke primary prevention.https://www.mdpi.com/2072-6643/14/23/5056polygenic risk scorefruitstroke |
| spellingShingle | Jun Wang Jianxin Li Fangchao Liu Keyong Huang Xueli Yang Xiaoqing Liu Jie Cao Shufeng Chen Chong Shen Ling Yu Fanghong Lu Liancheng Zhao Ying Li Dongsheng Hu Jianfeng Huang Dongfeng Gu Xiangfeng Lu Genetic Predisposition, Fruit Intake and Incident Stroke: A Prospective Chinese Cohort Study Nutrients polygenic risk score fruit stroke |
| title | Genetic Predisposition, Fruit Intake and Incident Stroke: A Prospective Chinese Cohort Study |
| title_full | Genetic Predisposition, Fruit Intake and Incident Stroke: A Prospective Chinese Cohort Study |
| title_fullStr | Genetic Predisposition, Fruit Intake and Incident Stroke: A Prospective Chinese Cohort Study |
| title_full_unstemmed | Genetic Predisposition, Fruit Intake and Incident Stroke: A Prospective Chinese Cohort Study |
| title_short | Genetic Predisposition, Fruit Intake and Incident Stroke: A Prospective Chinese Cohort Study |
| title_sort | genetic predisposition fruit intake and incident stroke a prospective chinese cohort study |
| topic | polygenic risk score fruit stroke |
| url | https://www.mdpi.com/2072-6643/14/23/5056 |
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