Evaluating the effects of S-ketamine on postoperative delirium in elderly patients following total hip or knee arthroplasty under intraspinal anesthesia: a single-center randomized, double-blind, placebo-controlled, pragmatic study protocol

Evaluating the effects of S-ketamine on postoperative delirium in elderly patients following total hip or knee arthroplasty under intraspinal anesthesia: a single-center randomized, double-blind, placebo-controlled, pragmatic study protocol

IntroductionPostoperative delirium (POD) is an acute, transient brain disorder associated with decreased postoperative quality of life, dementia, neurocognitive changes, and mortality. A small number of trials have explored the role of S-ketamine in the treatment of POD due to its neuroprotective ef...

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Bibliographic Details
Main Authors: Youzhuang Zhu, Wei Feng, Qinghan Kong, Fang Sheng, Zhichao Li, Weilong Xu, Qun Li, Yan Han, Xiuyun Wu, Changxin Jia, Jie Guo, Yang Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Aging Neuroscience
Subjects:
S-ketamine
postoperative delirium
neurocognitive disorders
neuroprotective effect
pragmatic study
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2023.1298661/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2023.1298661/full

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