The miR-130a-3p/TGF-βRII Axis Participates in Inhibiting the Differentiation of Fibroblasts Induced by TGF-β1

The miR-130a-3p/TGF-βRII Axis Participates in Inhibiting the Differentiation of Fibroblasts Induced by TGF-β1

Pulmonary fibrosis (PF) is a chronic progressive interstitial lung disease that has a poor prognosis. Abnormal activation of transforming growth factor-β1 (TGF-β1) plays a crucial role in fibroblast differentiation. Mesenchymal stem cells (MSCs) are currently being considered for the treatment of PF...

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Bibliographic Details
Main Authors: Yanhong Liu, Yan Ding, Yapeng Hou, Tong Yu, Hongguang Nie, Yong Cui
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Pharmacology
Subjects:
pulmonary fibrosis
mesenchymal stem cells
mouse lung fibroblast
microRNA
TGF-β1
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.732540/full

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