Genetic Analysis of Glycoprotein Gene of Indonesian Rabies Virus
The amino acid sequences of the Glycoprotein gene (G gene) of field rabies virus SN01-23 from Indonesia was determined. This isolate showed homology of 93% in the ectodomain of the Glycoprotein gene to that of the RC-HL strain, which is used for production of animal vaccine in Japan. The high identi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Universitas Gadjah Mada, Yogyakarta
2005-06-01
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| Series: | Indonesian Journal of Biotechnology |
| Online Access: | https://jurnal.ugm.ac.id/ijbiotech/article/view/7413 |
| _version_ | 1818478647738105856 |
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| author | Heru Susetya Ito Naoto Makoto Sugiyama Nobuyuki Minamoto |
| author_facet | Heru Susetya Ito Naoto Makoto Sugiyama Nobuyuki Minamoto |
| author_sort | Heru Susetya |
| collection | DOAJ |
| description | The amino acid sequences of the Glycoprotein gene (G gene) of field rabies virus SN01-23 from Indonesia
was determined. This isolate showed homology of 93% in the ectodomain of the Glycoprotein gene to that of the
RC-HL strain, which is used for production of animal vaccine in Japan. The high identity in the ectodomain
between this field isolate and strain RC-HL suggest that the rabies animal vaccine used in Japan will be effective
for rabies street viruses in Indonesia. Result of phylogenetic analysis using the nucleotide sequences of the G
genes of rabies street viruses showed that SN01-23 from Indonesia is more closely related to a rabies virus from
China than to viruses from Thailand and Malaysia. This genetic data and historical background suggest that
rabies viruses in China had been transferred to Indonesia through dogs brought by humans migrating from China
to Indonesia.
Keywords : Rabies virus, Glycoprotein gene, Ectodomain, Phylogenetic analysis |
| first_indexed | 2024-12-10T09:50:19Z |
| format | Article |
| id | doaj.art-63a3664d825b4cef975d9693ace6da38 |
| institution | Directory Open Access Journal |
| issn | 0853-8654 2089-2241 |
| language | English |
| last_indexed | 2024-12-10T09:50:19Z |
| publishDate | 2005-06-01 |
| publisher | Universitas Gadjah Mada, Yogyakarta |
| record_format | Article |
| series | Indonesian Journal of Biotechnology |
| spelling | doaj.art-63a3664d825b4cef975d9693ace6da382022-12-22T01:53:41ZengUniversitas Gadjah Mada, YogyakartaIndonesian Journal of Biotechnology0853-86542089-22412005-06-0110110.22146/ijbiotech.74136246Genetic Analysis of Glycoprotein Gene of Indonesian Rabies VirusHeru SusetyaIto NaotoMakoto SugiyamaNobuyuki MinamotoThe amino acid sequences of the Glycoprotein gene (G gene) of field rabies virus SN01-23 from Indonesia was determined. This isolate showed homology of 93% in the ectodomain of the Glycoprotein gene to that of the RC-HL strain, which is used for production of animal vaccine in Japan. The high identity in the ectodomain between this field isolate and strain RC-HL suggest that the rabies animal vaccine used in Japan will be effective for rabies street viruses in Indonesia. Result of phylogenetic analysis using the nucleotide sequences of the G genes of rabies street viruses showed that SN01-23 from Indonesia is more closely related to a rabies virus from China than to viruses from Thailand and Malaysia. This genetic data and historical background suggest that rabies viruses in China had been transferred to Indonesia through dogs brought by humans migrating from China to Indonesia. Keywords : Rabies virus, Glycoprotein gene, Ectodomain, Phylogenetic analysishttps://jurnal.ugm.ac.id/ijbiotech/article/view/7413 |
| spellingShingle | Heru Susetya Ito Naoto Makoto Sugiyama Nobuyuki Minamoto Genetic Analysis of Glycoprotein Gene of Indonesian Rabies Virus Indonesian Journal of Biotechnology |
| title | Genetic Analysis of Glycoprotein Gene of Indonesian Rabies Virus |
| title_full | Genetic Analysis of Glycoprotein Gene of Indonesian Rabies Virus |
| title_fullStr | Genetic Analysis of Glycoprotein Gene of Indonesian Rabies Virus |
| title_full_unstemmed | Genetic Analysis of Glycoprotein Gene of Indonesian Rabies Virus |
| title_short | Genetic Analysis of Glycoprotein Gene of Indonesian Rabies Virus |
| title_sort | genetic analysis of glycoprotein gene of indonesian rabies virus |
| url | https://jurnal.ugm.ac.id/ijbiotech/article/view/7413 |
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