C-type lectin-like receptor (CLEC)-2, the ligand of podoplanin, induces morphological changes in podocytes

C-type lectin-like receptor (CLEC)-2, the ligand of podoplanin, induces morphological changes in podocytes

Abstract Podoplanin (PDPN) is intensely expressed on the podocyte membrane in an evolutionally conserved manner. CLEC-2, the endogenous ligand of PDPN, is highly expressed in platelets and also exists in a soluble form in plasma. Normally, podocytes are sequestered from CLEC-2, but when the glomerul...

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Bibliographic Details
Main Authors: Keiko Tanaka, Masafumi Tanaka, Nobuo Watanabe, Masatoshi Ito, Ira Pastan, Masahiro Koizumi, Taiji Matsusaka
Format: Article
Language:English
Published: Nature Portfolio 2022-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-26456-9

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