Ultrasound-guided microwave ablation for tertiary hyperparathyroidism in patients with renal transplantation
AbstractObjective To explore the safety and efficacy of ultrasound-guided microwave ablation (MWA) for tertiary hyperparathyroidism (THPT) in patients with renal transplantation (RT).Methods In total, fifteen patients with THPT after renal transplantation who underwent MWA were enrolled in the study...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | International Journal of Hyperthermia |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/02656736.2023.2256497 |
| _version_ | 1797374221364494336 |
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| author | Boyang Yu Jiawu Li Chunyan Lu Qiang Lu Yaxin Zhou Yan Luo |
| author_facet | Boyang Yu Jiawu Li Chunyan Lu Qiang Lu Yaxin Zhou Yan Luo |
| author_sort | Boyang Yu |
| collection | DOAJ |
| description | AbstractObjective To explore the safety and efficacy of ultrasound-guided microwave ablation (MWA) for tertiary hyperparathyroidism (THPT) in patients with renal transplantation (RT).Methods In total, fifteen patients with THPT after renal transplantation who underwent MWA were enrolled in the study. The pre- and post-MWA intact parathyroid hormone (iPTH), serum calcium, phosphorus, creatinine, urea nitrogen and estimated glomerular filtration rate (eGFR) values were compared.Results A total of 38 parathyroid hyperplastic nodules in 15 RT patients were treated with ultrasound-guided MWA. The mean (median, range) size of the hyperplastic parathyroid nodules was 11.5 mm (11 mm, 5–25 mm), and the average (median, range) ablation time was 163.5s (121 s, 44–406 s). The average levels of serum iPTH and calcium at 1 d, 7 d, 1 month, 3 months, 6 months, 1 year post-MWA and at the end of follow-up were significantly lower than those pre-MWA (all p < 0.05). Compared with the pre-MWA value (0.76 mmol/L), the serum phosphorus levels at 1 d post-MWA (0.63 mmol/L) were significantly decreased, and those at 7 d, 1 month, 3 months, 6 months, 1 year post-MWA and at the end of follow-up were significantly increased, but all were within the normal range. There was no significant difference in serum creatinine and eGFR pre-MWA and post-MWA. No major MWA-related complications occurred.Conclusion Ultrasound-guided MWA shows potential as a viable treatment for THPT in RT patients. However, further studies are required to confirm its safety and effectiveness in larger cohorts of longer duration. |
| first_indexed | 2024-03-08T19:02:47Z |
| format | Article |
| id | doaj.art-63a642b4f78e42c785569f1652a656e0 |
| institution | Directory Open Access Journal |
| issn | 0265-6736 1464-5157 |
| language | English |
| last_indexed | 2024-03-08T19:02:47Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Hyperthermia |
| spelling | doaj.art-63a642b4f78e42c785569f1652a656e02023-12-28T04:15:43ZengTaylor & Francis GroupInternational Journal of Hyperthermia0265-67361464-51572023-12-0140110.1080/02656736.2023.2256497Ultrasound-guided microwave ablation for tertiary hyperparathyroidism in patients with renal transplantationBoyang Yu0Jiawu Li1Chunyan Lu2Qiang Lu3Yaxin Zhou4Yan Luo5Department of Ultrasound, West China Hospital of Sichuan University, Chengdu, Sichuan Province, ChinaDepartment of Ultrasound, West China Hospital of Sichuan University, Chengdu, Sichuan Province, ChinaDepartment of Endocrinology and Metabolism, West China Hospital of Sichuan University, Chengdu, Sichuan Province, ChinaDepartment of Ultrasound, West China Hospital of Sichuan University, Chengdu, Sichuan Province, ChinaDepartment of Ultrasound, West China Hospital of Sichuan University, Chengdu, Sichuan Province, ChinaDepartment of Ultrasound, West China Hospital of Sichuan University, Chengdu, Sichuan Province, ChinaAbstractObjective To explore the safety and efficacy of ultrasound-guided microwave ablation (MWA) for tertiary hyperparathyroidism (THPT) in patients with renal transplantation (RT).Methods In total, fifteen patients with THPT after renal transplantation who underwent MWA were enrolled in the study. The pre- and post-MWA intact parathyroid hormone (iPTH), serum calcium, phosphorus, creatinine, urea nitrogen and estimated glomerular filtration rate (eGFR) values were compared.Results A total of 38 parathyroid hyperplastic nodules in 15 RT patients were treated with ultrasound-guided MWA. The mean (median, range) size of the hyperplastic parathyroid nodules was 11.5 mm (11 mm, 5–25 mm), and the average (median, range) ablation time was 163.5s (121 s, 44–406 s). The average levels of serum iPTH and calcium at 1 d, 7 d, 1 month, 3 months, 6 months, 1 year post-MWA and at the end of follow-up were significantly lower than those pre-MWA (all p < 0.05). Compared with the pre-MWA value (0.76 mmol/L), the serum phosphorus levels at 1 d post-MWA (0.63 mmol/L) were significantly decreased, and those at 7 d, 1 month, 3 months, 6 months, 1 year post-MWA and at the end of follow-up were significantly increased, but all were within the normal range. There was no significant difference in serum creatinine and eGFR pre-MWA and post-MWA. No major MWA-related complications occurred.Conclusion Ultrasound-guided MWA shows potential as a viable treatment for THPT in RT patients. However, further studies are required to confirm its safety and effectiveness in larger cohorts of longer duration.https://www.tandfonline.com/doi/10.1080/02656736.2023.2256497Tertiary hyperparathyroidismkidney transplantationmicrowave ablationultrasound-guidedefficacy |
| spellingShingle | Boyang Yu Jiawu Li Chunyan Lu Qiang Lu Yaxin Zhou Yan Luo Ultrasound-guided microwave ablation for tertiary hyperparathyroidism in patients with renal transplantation International Journal of Hyperthermia Tertiary hyperparathyroidism kidney transplantation microwave ablation ultrasound-guided efficacy |
| title | Ultrasound-guided microwave ablation for tertiary hyperparathyroidism in patients with renal transplantation |
| title_full | Ultrasound-guided microwave ablation for tertiary hyperparathyroidism in patients with renal transplantation |
| title_fullStr | Ultrasound-guided microwave ablation for tertiary hyperparathyroidism in patients with renal transplantation |
| title_full_unstemmed | Ultrasound-guided microwave ablation for tertiary hyperparathyroidism in patients with renal transplantation |
| title_short | Ultrasound-guided microwave ablation for tertiary hyperparathyroidism in patients with renal transplantation |
| title_sort | ultrasound guided microwave ablation for tertiary hyperparathyroidism in patients with renal transplantation |
| topic | Tertiary hyperparathyroidism kidney transplantation microwave ablation ultrasound-guided efficacy |
| url | https://www.tandfonline.com/doi/10.1080/02656736.2023.2256497 |
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