The Association of Aspartate Aminotransferase/Alanine Aminotransferase Ratio with Diabetic Nephropathy in Patients with Type 2 Diabetes
Jing Xu, Xiaomin Shi, Youjin Pan Department of Endocrinology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, People’s Republic of ChinaCorrespondence: Youjin PanDepartment of Endocrinology, The Second Affiliated Hospital and Yuying Children’s Ho...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2021-09-01
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| Series: | Diabetes, Metabolic Syndrome and Obesity |
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| Online Access: | https://www.dovepress.com/the-association-of-aspartate-aminotransferasealanine-aminotransferase--peer-reviewed-fulltext-article-DMSO |
| _version_ | 1797935180288098304 |
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| author | Xu J Shi X Pan Y |
| author_facet | Xu J Shi X Pan Y |
| author_sort | Xu J |
| collection | DOAJ |
| description | Jing Xu, Xiaomin Shi, Youjin Pan Department of Endocrinology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, People’s Republic of ChinaCorrespondence: Youjin PanDepartment of Endocrinology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Lucheng District, Wenzhou, Zhejiang Province, People’s Republic of ChinaTel +86 15068256508Fax +86 577-85678813Email panyj6190@163.comPurpose: To investigate the relationship between aspartate aminotransferase to alanine aminotransferase ratio (AST/ALT) and diabetic nephropathy (DN).Patients and Methods: A total of 402 patients with type 2 diabetes mellitus were divided into three groups, such as normoalbuminuria (n = 196), microalbuminuria (n = 131) and macroalbuminuria (n = 75) groups. Basic information and laboratory results were collected. Serum AST/ALT, tumor necrosis factor-α (TNF-α), interleukin (IL)-2, IL-4, IL-6, IL-10 and interferon- γ (INF- γ) were also measured. DN was defined as microalbuminuria or macroalbuminuria. The estimated glomerular filtration rate (eGFR) was calculated using the following formula: 186 × (serum creatinine)− 1.154× (age)− 0.203× (0.742 if female).Results: The AST/ALT in the macroalbuminuria group was higher than in the microalbuminuria and normoalbuminuria groups. The concentrations of tumor necrosis factor-α (TNF-α), IL-2, IL-4, IL-10 and INF-γ in the macroalbuminuria group were significantly higher than those in the two other groups. Multivariate logistical analysis showed that after adjusting confounding factors, TNF-α and high AST/ALT were independent risks for DN and macroalbuminuria. Furthermore, the AST/ALT had significantly positive correlation with TNF-α (r = 0.101, P = 0.048), IL-4 (r = 0.185, P = 0.005) and IL-6 (r = 0.274, P < 0.001) levels.Conclusion: This study showed that high AST/ALT was an independent risk factor for the DN. Additionally, AST/ALT was positively correlated with inflammation cytokines, such as TNF-α, IL-4 and IL-6 levels.Keywords: AST/ALT, diabetic nephropathy, inflammatory factors, tumor necrosis factor-α |
| first_indexed | 2024-04-10T18:10:23Z |
| format | Article |
| id | doaj.art-63a68bd2ed4d400ca7ffdcbd460d55a9 |
| institution | Directory Open Access Journal |
| issn | 1178-7007 |
| language | English |
| last_indexed | 2024-04-10T18:10:23Z |
| publishDate | 2021-09-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Diabetes, Metabolic Syndrome and Obesity |
| spelling | doaj.art-63a68bd2ed4d400ca7ffdcbd460d55a92023-02-02T11:02:36ZengDove Medical PressDiabetes, Metabolic Syndrome and Obesity1178-70072021-09-01Volume 143831383768552The Association of Aspartate Aminotransferase/Alanine Aminotransferase Ratio with Diabetic Nephropathy in Patients with Type 2 DiabetesXu JShi XPan YJing Xu, Xiaomin Shi, Youjin Pan Department of Endocrinology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, People’s Republic of ChinaCorrespondence: Youjin PanDepartment of Endocrinology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Lucheng District, Wenzhou, Zhejiang Province, People’s Republic of ChinaTel +86 15068256508Fax +86 577-85678813Email panyj6190@163.comPurpose: To investigate the relationship between aspartate aminotransferase to alanine aminotransferase ratio (AST/ALT) and diabetic nephropathy (DN).Patients and Methods: A total of 402 patients with type 2 diabetes mellitus were divided into three groups, such as normoalbuminuria (n = 196), microalbuminuria (n = 131) and macroalbuminuria (n = 75) groups. Basic information and laboratory results were collected. Serum AST/ALT, tumor necrosis factor-α (TNF-α), interleukin (IL)-2, IL-4, IL-6, IL-10 and interferon- γ (INF- γ) were also measured. DN was defined as microalbuminuria or macroalbuminuria. The estimated glomerular filtration rate (eGFR) was calculated using the following formula: 186 × (serum creatinine)− 1.154× (age)− 0.203× (0.742 if female).Results: The AST/ALT in the macroalbuminuria group was higher than in the microalbuminuria and normoalbuminuria groups. The concentrations of tumor necrosis factor-α (TNF-α), IL-2, IL-4, IL-10 and INF-γ in the macroalbuminuria group were significantly higher than those in the two other groups. Multivariate logistical analysis showed that after adjusting confounding factors, TNF-α and high AST/ALT were independent risks for DN and macroalbuminuria. Furthermore, the AST/ALT had significantly positive correlation with TNF-α (r = 0.101, P = 0.048), IL-4 (r = 0.185, P = 0.005) and IL-6 (r = 0.274, P < 0.001) levels.Conclusion: This study showed that high AST/ALT was an independent risk factor for the DN. Additionally, AST/ALT was positively correlated with inflammation cytokines, such as TNF-α, IL-4 and IL-6 levels.Keywords: AST/ALT, diabetic nephropathy, inflammatory factors, tumor necrosis factor-αhttps://www.dovepress.com/the-association-of-aspartate-aminotransferasealanine-aminotransferase--peer-reviewed-fulltext-article-DMSOast/altdiabetic nephropathyinflammatory factorstumor necrosis factor-α |
| spellingShingle | Xu J Shi X Pan Y The Association of Aspartate Aminotransferase/Alanine Aminotransferase Ratio with Diabetic Nephropathy in Patients with Type 2 Diabetes Diabetes, Metabolic Syndrome and Obesity ast/alt diabetic nephropathy inflammatory factors tumor necrosis factor-α |
| title | The Association of Aspartate Aminotransferase/Alanine Aminotransferase Ratio with Diabetic Nephropathy in Patients with Type 2 Diabetes |
| title_full | The Association of Aspartate Aminotransferase/Alanine Aminotransferase Ratio with Diabetic Nephropathy in Patients with Type 2 Diabetes |
| title_fullStr | The Association of Aspartate Aminotransferase/Alanine Aminotransferase Ratio with Diabetic Nephropathy in Patients with Type 2 Diabetes |
| title_full_unstemmed | The Association of Aspartate Aminotransferase/Alanine Aminotransferase Ratio with Diabetic Nephropathy in Patients with Type 2 Diabetes |
| title_short | The Association of Aspartate Aminotransferase/Alanine Aminotransferase Ratio with Diabetic Nephropathy in Patients with Type 2 Diabetes |
| title_sort | association of aspartate aminotransferase alanine aminotransferase ratio with diabetic nephropathy in patients with type 2 diabetes |
| topic | ast/alt diabetic nephropathy inflammatory factors tumor necrosis factor-α |
| url | https://www.dovepress.com/the-association-of-aspartate-aminotransferasealanine-aminotransferase--peer-reviewed-fulltext-article-DMSO |
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