Effect of valerian on cognitive disorders and electroencephalography in hemodialysis patients: a randomized, cross over, double-blind clinical trial
Abstract Background The prevalence of cognitive disorders in hemodialysis patients is twice as high as the general population, while these disorders often are undiagnosed. Timely prevention and treatment can improve their personal and social functions. Aim of study was determined the effect of Valer...
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| Format: | Article |
| Language: | English |
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BMC
2018-12-01
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| Series: | BMC Nephrology |
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| Online Access: | http://link.springer.com/article/10.1186/s12882-018-1134-8 |
| _version_ | 1811269443491201024 |
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| author | Afshin Samaei Monir Nobahar Zaynab Hydarinia-Naieni Abbas Ali Ebrahimian Mohammad Reza Tammadon Raheb Ghorbani Abbas Ali Vafaei |
| author_facet | Afshin Samaei Monir Nobahar Zaynab Hydarinia-Naieni Abbas Ali Ebrahimian Mohammad Reza Tammadon Raheb Ghorbani Abbas Ali Vafaei |
| author_sort | Afshin Samaei |
| collection | DOAJ |
| description | Abstract Background The prevalence of cognitive disorders in hemodialysis patients is twice as high as the general population, while these disorders often are undiagnosed. Timely prevention and treatment can improve their personal and social functions. Aim of study was determined the effect of Valerian on cognitive disorders and electroencephalography (EGG) in hemodialysis patients. Methods This crossover, double-blind clinical trial was conducted on 39 hemodialysis patients. The patients were randomly divided into two groups. Group A (n = 19) took Valerian capsules and Group B (n = 20) received placebo capsules 60 min before bedtime for one month. The type of treatment was replaced between the two groups after a one-month wash-out. The Mini Mental State Examination (MMSE) questionnaire was completed and EGG was performed before and after intervention in both periods. Results The cognitive scores of the Group valerian were increased significantly in the first (p = 0.003) and the second (p = 0.005) periods. In addition, the mean increase in the cognitive scores in the Group valerian was significant in the first (p = 0.028) and the second periods (p = 0.030). However, the changes in EGG showed no significant difference before and after intervention in two groups. Conclusion The findings of this study indicated that valerian could be effective and significantly improve patients’ cognitive status; however, no significant changes were observed in the electroencephalography of the hemodialysis patients. Trial registration IRCT201606076318N7–2016-06-17. |
| first_indexed | 2024-04-12T21:42:08Z |
| format | Article |
| id | doaj.art-63a69e76f0164720815ff6c7c60eb77a |
| institution | Directory Open Access Journal |
| issn | 1471-2369 |
| language | English |
| last_indexed | 2024-04-12T21:42:08Z |
| publishDate | 2018-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj.art-63a69e76f0164720815ff6c7c60eb77a2022-12-22T03:15:44ZengBMCBMC Nephrology1471-23692018-12-0119111010.1186/s12882-018-1134-8Effect of valerian on cognitive disorders and electroencephalography in hemodialysis patients: a randomized, cross over, double-blind clinical trialAfshin Samaei0Monir Nobahar1Zaynab Hydarinia-Naieni2Abbas Ali Ebrahimian3Mohammad Reza Tammadon4Raheb Ghorbani5Abbas Ali Vafaei6Research Center and Department of Physiology, Faculty of Medicine, Semnan University of Medical SciencesNursing Care Research Center and Social Determinants of Health Research Center, Faculty of Nursing and Midwifery, Semnan University of Medical SciencesNursing Care Research Center, Semnan University of Medical SciencesDepartment of Nursing, Faculty of Nursing and Midwifery, Semnan University of Medical SciencesKowsar Hospital, Semnan University of Medical SciencesSocial Determinants of Health Research Center, Department of Epidemiology and Biostatistics, Faculty of Medicine, Semnan University of Medical SciencesRehabilitation Research Center, Neurology Department, Kowsar Hospital, Faculty of Medicine, Semnan University of Medical SciencesAbstract Background The prevalence of cognitive disorders in hemodialysis patients is twice as high as the general population, while these disorders often are undiagnosed. Timely prevention and treatment can improve their personal and social functions. Aim of study was determined the effect of Valerian on cognitive disorders and electroencephalography (EGG) in hemodialysis patients. Methods This crossover, double-blind clinical trial was conducted on 39 hemodialysis patients. The patients were randomly divided into two groups. Group A (n = 19) took Valerian capsules and Group B (n = 20) received placebo capsules 60 min before bedtime for one month. The type of treatment was replaced between the two groups after a one-month wash-out. The Mini Mental State Examination (MMSE) questionnaire was completed and EGG was performed before and after intervention in both periods. Results The cognitive scores of the Group valerian were increased significantly in the first (p = 0.003) and the second (p = 0.005) periods. In addition, the mean increase in the cognitive scores in the Group valerian was significant in the first (p = 0.028) and the second periods (p = 0.030). However, the changes in EGG showed no significant difference before and after intervention in two groups. Conclusion The findings of this study indicated that valerian could be effective and significantly improve patients’ cognitive status; however, no significant changes were observed in the electroencephalography of the hemodialysis patients. Trial registration IRCT201606076318N7–2016-06-17.http://link.springer.com/article/10.1186/s12882-018-1134-8Cognitive Disorders & ElectroencephalographyHemodialysisValerian |
| spellingShingle | Afshin Samaei Monir Nobahar Zaynab Hydarinia-Naieni Abbas Ali Ebrahimian Mohammad Reza Tammadon Raheb Ghorbani Abbas Ali Vafaei Effect of valerian on cognitive disorders and electroencephalography in hemodialysis patients: a randomized, cross over, double-blind clinical trial BMC Nephrology Cognitive Disorders & Electroencephalography Hemodialysis Valerian |
| title | Effect of valerian on cognitive disorders and electroencephalography in hemodialysis patients: a randomized, cross over, double-blind clinical trial |
| title_full | Effect of valerian on cognitive disorders and electroencephalography in hemodialysis patients: a randomized, cross over, double-blind clinical trial |
| title_fullStr | Effect of valerian on cognitive disorders and electroencephalography in hemodialysis patients: a randomized, cross over, double-blind clinical trial |
| title_full_unstemmed | Effect of valerian on cognitive disorders and electroencephalography in hemodialysis patients: a randomized, cross over, double-blind clinical trial |
| title_short | Effect of valerian on cognitive disorders and electroencephalography in hemodialysis patients: a randomized, cross over, double-blind clinical trial |
| title_sort | effect of valerian on cognitive disorders and electroencephalography in hemodialysis patients a randomized cross over double blind clinical trial |
| topic | Cognitive Disorders & Electroencephalography Hemodialysis Valerian |
| url | http://link.springer.com/article/10.1186/s12882-018-1134-8 |
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