Human B Cell Differentiation Is Characterized by Progressive Remodeling of O-Linked Glycans

Human B Cell Differentiation Is Characterized by Progressive Remodeling of O-Linked Glycans

Germinal centers (GC) are microanatomical niches where B cells proliferate, undergo antibody affinity maturation, and differentiate to long-lived memory B cells and antibody-secreting plasma cells. For decades, GC B cells have been defined by their reactivity to the plant lectin peanut agglutinin (P...

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Bibliographic Details
Main Authors: Nicholas Giovannone, Aristotelis Antonopoulos, Jennifer Liang, Jenna Geddes Sweeney, Matthew R. Kudelka, Sandra L. King, Gi Soo Lee, Richard D. Cummings, Anne Dell, Steven R. Barthel, Hans R. Widlund, Stuart M. Haslam, Charles J. Dimitroff
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Immunology
Subjects:
glycosylation
glycan
B cell
CD45
peanut lectin
PNA
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02857/full

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