Using Chemerin and Inflammation Markers to Predict Coronary Ar-tery Disease in Metabolic Syndrome Patients
The systemic inflammation plays a role in both metabolic syndrome (MetS) and coronary artery disease (CAD). This study was undertaken to determine chemerin's role and inflammation indicators in the emergence of CAD in MetS patients. The study was conducted on 120 subjects (male and female), w...
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| Format: | Article |
| Language: | English |
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College of Education for Pure Sciences
2023-12-01
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| Series: | Wasit Journal for Pure Sciences |
| Subjects: | |
| Online Access: | https://wjps.uowasit.edu.iq/index.php/wjps/article/view/232 |
| _version_ | 1797288433382588416 |
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| author | Noor Hanoush Salahaldin Mohammed Fahad Lara Abdulmageed |
| author_facet | Noor Hanoush Salahaldin Mohammed Fahad Lara Abdulmageed |
| author_sort | Noor Hanoush |
| collection | DOAJ |
| description |
The systemic inflammation plays a role in both metabolic syndrome (MetS) and coronary artery disease (CAD). This study was undertaken to determine chemerin's role and inflammation indicators in the emergence of CAD in MetS patients. The study was conducted on 120 subjects (male and female), whose ages (35 to 65)years. The study subjects divided into three groups which are 45 MetS patients with CAD and 40 MetS patients without CAD, and 25 control, who underwent coronary angiography for the evaluation of CAD. The chemerin level, as well as the levels of inflammatory markers such as interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs-CRP), leptin, and tumor necrosis factor-alpha (TNF-α), were measured by enzyme-linked immunosorbent assay (ELIZA). The results show that the concentrations of chemerin, TNF-α, leptin, and Il-6 were significantly elevated in MetS patients with CAD compared with control group. Triglycerides, cholesterol, and LDL-C were significantly increased, while HDL-C was significantly decreased in MetS patients compared with control. The present study show that chemerin is associated with markers of inflammation and predictors such as IL-6, hs-CRP and TNF-alpha, which important risk factors determining CAD in Iraqi subjects with MetS. Adipokines might also be seen as crucial clinical biomarkers and pharmacological targets for lowering the mortality and incidence of CAD in MetS patients.
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| first_indexed | 2024-03-07T18:49:25Z |
| format | Article |
| id | doaj.art-63a825d9e25446d2bbc86b311d096a44 |
| institution | Directory Open Access Journal |
| issn | 2790-5233 2790-5241 |
| language | English |
| last_indexed | 2024-03-07T18:49:25Z |
| publishDate | 2023-12-01 |
| publisher | College of Education for Pure Sciences |
| record_format | Article |
| series | Wasit Journal for Pure Sciences |
| spelling | doaj.art-63a825d9e25446d2bbc86b311d096a442024-03-02T02:02:33ZengCollege of Education for Pure SciencesWasit Journal for Pure Sciences2790-52332790-52412023-12-012410.31185/wjps.232Using Chemerin and Inflammation Markers to Predict Coronary Ar-tery Disease in Metabolic Syndrome PatientsNoor Hanoush0Salahaldin Mohammed Fahad1Lara Abdulmageed2University Of AnbarDirectorate of Education- Anbar, Al-Anbar, IraqUniversity Of Anbar The systemic inflammation plays a role in both metabolic syndrome (MetS) and coronary artery disease (CAD). This study was undertaken to determine chemerin's role and inflammation indicators in the emergence of CAD in MetS patients. The study was conducted on 120 subjects (male and female), whose ages (35 to 65)years. The study subjects divided into three groups which are 45 MetS patients with CAD and 40 MetS patients without CAD, and 25 control, who underwent coronary angiography for the evaluation of CAD. The chemerin level, as well as the levels of inflammatory markers such as interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs-CRP), leptin, and tumor necrosis factor-alpha (TNF-α), were measured by enzyme-linked immunosorbent assay (ELIZA). The results show that the concentrations of chemerin, TNF-α, leptin, and Il-6 were significantly elevated in MetS patients with CAD compared with control group. Triglycerides, cholesterol, and LDL-C were significantly increased, while HDL-C was significantly decreased in MetS patients compared with control. The present study show that chemerin is associated with markers of inflammation and predictors such as IL-6, hs-CRP and TNF-alpha, which important risk factors determining CAD in Iraqi subjects with MetS. Adipokines might also be seen as crucial clinical biomarkers and pharmacological targets for lowering the mortality and incidence of CAD in MetS patients. https://wjps.uowasit.edu.iq/index.php/wjps/article/view/232Metabolic syndromeChemerinCoronary Artery DiseaseLeptin |
| spellingShingle | Noor Hanoush Salahaldin Mohammed Fahad Lara Abdulmageed Using Chemerin and Inflammation Markers to Predict Coronary Ar-tery Disease in Metabolic Syndrome Patients Wasit Journal for Pure Sciences Metabolic syndrome Chemerin Coronary Artery Disease Leptin |
| title | Using Chemerin and Inflammation Markers to Predict Coronary Ar-tery Disease in Metabolic Syndrome Patients |
| title_full | Using Chemerin and Inflammation Markers to Predict Coronary Ar-tery Disease in Metabolic Syndrome Patients |
| title_fullStr | Using Chemerin and Inflammation Markers to Predict Coronary Ar-tery Disease in Metabolic Syndrome Patients |
| title_full_unstemmed | Using Chemerin and Inflammation Markers to Predict Coronary Ar-tery Disease in Metabolic Syndrome Patients |
| title_short | Using Chemerin and Inflammation Markers to Predict Coronary Ar-tery Disease in Metabolic Syndrome Patients |
| title_sort | using chemerin and inflammation markers to predict coronary ar tery disease in metabolic syndrome patients |
| topic | Metabolic syndrome Chemerin Coronary Artery Disease Leptin |
| url | https://wjps.uowasit.edu.iq/index.php/wjps/article/view/232 |
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