Inhibitors of the integrase–transportin-SR2 interaction block HIV nuclear import

Inhibitors of the integrase–transportin-SR2 interaction block HIV nuclear import

Abstract Background Combination antiretroviral therapy efficiently suppresses HIV replication in infected patients, transforming HIV/AIDS into a chronic disease. Viral resistance does develop however, especially under suboptimal treatment conditions such as poor adherence. As a consequence, continue...

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Bibliographic Details
Main Authors: Jonas Demeulemeester, Jolien Blokken, Stéphanie De Houwer, Lieve Dirix, Hugo Klaassen, Arnaud Marchand, Patrick Chaltin, Frauke Christ, Zeger Debyser
Format: Article
Language:English
Published: BMC 2018-01-01
Series:Retrovirology
Subjects:
Drug discovery
Integrase
Transportin-SR2
HIV
Nuclear import
Online Access:http://link.springer.com/article/10.1186/s12977-018-0389-2

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