Mitochondrial ClpX activates an essential biosynthetic enzyme through partial unfolding

Mitochondrial ClpX activates an essential biosynthetic enzyme through partial unfolding

Mitochondria control the activity, quality, and lifetime of their proteins with an autonomous system of chaperones, but the signals that direct substrate-chaperone interactions and outcomes are poorly understood. We previously discovered that the mitochondrial AAA+ protein unfoldase ClpX (mtClpX) ac...

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Bibliographic Details
Main Authors: Julia R Kardon, Jamie A Moroco, John R Engen, Tania A Baker
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-02-01
Series:eLife
Subjects:
ClpX
heme biosynthesis
chaperone
ALAS
pyridoxal phosphate
mitochondria
Online Access:https://elifesciences.org/articles/54387

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