Brain Death-Induced Inflammatory Activity is Similar to Sepsis-Induced Cytokine Release
Brain death (BD) is associated with a systemic inflammation leading to worse graft outcomes. This study aimed to compare plasma cytokine values between brain-dead and critically ill patients, including septic and non-septic controls, and evaluate cytokine release kinetics in BD. Sixteen brain-dead a...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2018-10-01
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| Series: | Cell Transplantation |
| Online Access: | https://doi.org/10.1177/0963689718785629 |
| _version_ | 1818940503992827904 |
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| author | Patrícia Schwarz Geisiane Custódio Jakeline Rheinheimer Daisy Crispim Cristiane B. Leitão Tatiana H. Rech |
| author_facet | Patrícia Schwarz Geisiane Custódio Jakeline Rheinheimer Daisy Crispim Cristiane B. Leitão Tatiana H. Rech |
| author_sort | Patrícia Schwarz |
| collection | DOAJ |
| description | Brain death (BD) is associated with a systemic inflammation leading to worse graft outcomes. This study aimed to compare plasma cytokine values between brain-dead and critically ill patients, including septic and non-septic controls, and evaluate cytokine release kinetics in BD. Sixteen brain-dead and 32 control patients (16 with and 16 without sepsis) were included. Plasma cytokines were measured by magnetic bead assay after the first clinical exam consistent with BD and every 6 hours thereafter, and at the time of study entry in the control group. The values for IL-8 and IFN-γ were higher in brain-dead and septic patients than in non-septic patients [IL-8: 80.3 (18.7–169.6) vs. 68.2 (22.4–359.4) vs. 16.4 (9.2–42.7) pg/mL; P = 0.006; IFN-γ: 2.8 (1.6-6.1) vs. 3.4 (1.2–9.0) vs. 0.5 (0.5–1.8) pg/mL; P = 0.012]. TNF showed a clear tendency to increase in brain-dead patients [2.7 (1.0–4.8) vs. 1.0 (1.0–5.6) vs. 1.0 (1.0–1.0) pg/mL; P = 0.051], and IL-6 values were higher in brain-dead patients than in non-septic controls [174.5 (104.9–692.5) vs. 13.2 (7.3–38.6) pg/mL; P = 0.002]. These differences remained even after excluding brain-dead patients who also had sepsis ( n = 3). IL-1β and IL-10 values increased from baseline to time point 2 (∼6 hours later) [IL-1β: 5.39 (1.93–16.89) vs. 7.11 (1.93–29.13) pg/mL; P = 0.012; IL-10: 8.78 (3.62–16.49) vs. 15.73 (5.49–23.98) pg/mL; P = 0.009]. BD-induced and sepsis-induced plasma cytokine values were similarly high, and both were higher than the observed in non-septic critically ill patients. |
| first_indexed | 2024-12-20T06:40:41Z |
| format | Article |
| id | doaj.art-63ad4a35b6a340c380b13f667f427879 |
| institution | Directory Open Access Journal |
| issn | 0963-6897 1555-3892 |
| language | English |
| last_indexed | 2024-12-20T06:40:41Z |
| publishDate | 2018-10-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Cell Transplantation |
| spelling | doaj.art-63ad4a35b6a340c380b13f667f4278792022-12-21T19:49:52ZengSAGE PublishingCell Transplantation0963-68971555-38922018-10-012710.1177/0963689718785629Brain Death-Induced Inflammatory Activity is Similar to Sepsis-Induced Cytokine ReleasePatrícia Schwarz0Geisiane Custódio1Jakeline Rheinheimer2Daisy Crispim3Cristiane B. Leitão4Tatiana H. Rech5 Intensive Care Unit, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil Graduate Program in Medical Sciences, Endocrinology, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil Endocrine Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil Endocrine Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil Endocrine Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil Intensive Care Unit, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, BrazilBrain death (BD) is associated with a systemic inflammation leading to worse graft outcomes. This study aimed to compare plasma cytokine values between brain-dead and critically ill patients, including septic and non-septic controls, and evaluate cytokine release kinetics in BD. Sixteen brain-dead and 32 control patients (16 with and 16 without sepsis) were included. Plasma cytokines were measured by magnetic bead assay after the first clinical exam consistent with BD and every 6 hours thereafter, and at the time of study entry in the control group. The values for IL-8 and IFN-γ were higher in brain-dead and septic patients than in non-septic patients [IL-8: 80.3 (18.7–169.6) vs. 68.2 (22.4–359.4) vs. 16.4 (9.2–42.7) pg/mL; P = 0.006; IFN-γ: 2.8 (1.6-6.1) vs. 3.4 (1.2–9.0) vs. 0.5 (0.5–1.8) pg/mL; P = 0.012]. TNF showed a clear tendency to increase in brain-dead patients [2.7 (1.0–4.8) vs. 1.0 (1.0–5.6) vs. 1.0 (1.0–1.0) pg/mL; P = 0.051], and IL-6 values were higher in brain-dead patients than in non-septic controls [174.5 (104.9–692.5) vs. 13.2 (7.3–38.6) pg/mL; P = 0.002]. These differences remained even after excluding brain-dead patients who also had sepsis ( n = 3). IL-1β and IL-10 values increased from baseline to time point 2 (∼6 hours later) [IL-1β: 5.39 (1.93–16.89) vs. 7.11 (1.93–29.13) pg/mL; P = 0.012; IL-10: 8.78 (3.62–16.49) vs. 15.73 (5.49–23.98) pg/mL; P = 0.009]. BD-induced and sepsis-induced plasma cytokine values were similarly high, and both were higher than the observed in non-septic critically ill patients.https://doi.org/10.1177/0963689718785629 |
| spellingShingle | Patrícia Schwarz Geisiane Custódio Jakeline Rheinheimer Daisy Crispim Cristiane B. Leitão Tatiana H. Rech Brain Death-Induced Inflammatory Activity is Similar to Sepsis-Induced Cytokine Release Cell Transplantation |
| title | Brain Death-Induced Inflammatory Activity is Similar to Sepsis-Induced Cytokine Release |
| title_full | Brain Death-Induced Inflammatory Activity is Similar to Sepsis-Induced Cytokine Release |
| title_fullStr | Brain Death-Induced Inflammatory Activity is Similar to Sepsis-Induced Cytokine Release |
| title_full_unstemmed | Brain Death-Induced Inflammatory Activity is Similar to Sepsis-Induced Cytokine Release |
| title_short | Brain Death-Induced Inflammatory Activity is Similar to Sepsis-Induced Cytokine Release |
| title_sort | brain death induced inflammatory activity is similar to sepsis induced cytokine release |
| url | https://doi.org/10.1177/0963689718785629 |
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