Chondrosterins A–E, Triquinane-Type Sesquiterpenoids from Soft Coral-Associated Fungus Chondrostereum sp.
The marine fungus Chondrostereum sp. was collected from a soft coral Sarcophyton tortuosum from the South China Sea. This fungus was cultured in potato dextrose broth medium and the culture broth was extracted with EtOAc. Five new triquinane-type sesquiterpenoids, chondrosterins A–E (1–5), and the k...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2012-03-01
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| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1660-3397/10/3/627/ |
| _version_ | 1811262915325460480 |
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| author | Zhong-Liang Xie Ying Chen Chi-Keung Lam Wen-Jian Lan Hou-Jin Li Ying-Lu Xie |
| author_facet | Zhong-Liang Xie Ying Chen Chi-Keung Lam Wen-Jian Lan Hou-Jin Li Ying-Lu Xie |
| author_sort | Zhong-Liang Xie |
| collection | DOAJ |
| description | The marine fungus Chondrostereum sp. was collected from a soft coral Sarcophyton tortuosum from the South China Sea. This fungus was cultured in potato dextrose broth medium and the culture broth was extracted with EtOAc. Five new triquinane-type sesquiterpenoids, chondrosterins A–E (1–5), and the known sesquiterpenoid hirsutanol C (6), were isolated. The structures were elucidated mainly on the basis of NMR, MS, and X-ray single-crystal diffraction data. Chondrosterin A (1) showed significant cytotoxic activities against cancer lines A549, CNE2, and LoVo with IC50 values of 2.45, 4.95, and 5.47 μM, respectively. |
| first_indexed | 2024-04-12T19:35:14Z |
| format | Article |
| id | doaj.art-63aef6ed2ea34004b96e5b425b58569d |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-12T19:35:14Z |
| publishDate | 2012-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-63aef6ed2ea34004b96e5b425b58569d2022-12-22T03:19:13ZengMDPI AGMarine Drugs1660-33972012-03-0110362763810.3390/md10030627Chondrosterins A–E, Triquinane-Type Sesquiterpenoids from Soft Coral-Associated Fungus Chondrostereum sp.Zhong-Liang XieYing ChenChi-Keung LamWen-Jian LanHou-Jin LiYing-Lu XieThe marine fungus Chondrostereum sp. was collected from a soft coral Sarcophyton tortuosum from the South China Sea. This fungus was cultured in potato dextrose broth medium and the culture broth was extracted with EtOAc. Five new triquinane-type sesquiterpenoids, chondrosterins A–E (1–5), and the known sesquiterpenoid hirsutanol C (6), were isolated. The structures were elucidated mainly on the basis of NMR, MS, and X-ray single-crystal diffraction data. Chondrosterin A (1) showed significant cytotoxic activities against cancer lines A549, CNE2, and LoVo with IC50 values of 2.45, 4.95, and 5.47 μM, respectively.http://www.mdpi.com/1660-3397/10/3/627/Chondrostereum sp.sesquiterpenoidschondrosterinsmarine funguscytotoxic activities |
| spellingShingle | Zhong-Liang Xie Ying Chen Chi-Keung Lam Wen-Jian Lan Hou-Jin Li Ying-Lu Xie Chondrosterins A–E, Triquinane-Type Sesquiterpenoids from Soft Coral-Associated Fungus Chondrostereum sp. Marine Drugs Chondrostereum sp. sesquiterpenoids chondrosterins marine fungus cytotoxic activities |
| title | Chondrosterins A–E, Triquinane-Type Sesquiterpenoids from Soft Coral-Associated Fungus Chondrostereum sp. |
| title_full | Chondrosterins A–E, Triquinane-Type Sesquiterpenoids from Soft Coral-Associated Fungus Chondrostereum sp. |
| title_fullStr | Chondrosterins A–E, Triquinane-Type Sesquiterpenoids from Soft Coral-Associated Fungus Chondrostereum sp. |
| title_full_unstemmed | Chondrosterins A–E, Triquinane-Type Sesquiterpenoids from Soft Coral-Associated Fungus Chondrostereum sp. |
| title_short | Chondrosterins A–E, Triquinane-Type Sesquiterpenoids from Soft Coral-Associated Fungus Chondrostereum sp. |
| title_sort | chondrosterins a e triquinane type sesquiterpenoids from soft coral associated fungus chondrostereum sp |
| topic | Chondrostereum sp. sesquiterpenoids chondrosterins marine fungus cytotoxic activities |
| url | http://www.mdpi.com/1660-3397/10/3/627/ |
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