The effect of the platelet-rich plasma and ozone therapy on tendon-to-bone healing in the rabbit rotator cuff repair model
Abstract Background The aim of this study is to histologically and biomechanically investigate the effects of local PRP and ozone therapy (O2O3) on tendon-to-bone healing in a rabbit model of the supraspinatus tendon tear. Methods Four groups were formed to have seven rabbits in each group: repair,...
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| Format: | Article |
| Language: | English |
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BMC
2021-03-01
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| Series: | Journal of Orthopaedic Surgery and Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13018-021-02320-w |
| _version_ | 1811182924622462976 |
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| author | Murat Gurger Gokhan Once Erhan Yilmaz Sukru Demir Ilknur Calik Yakup Say Ahmet Kavakli Sefa Key Mustafa Umit Gurbuz Onur Bingollu |
| author_facet | Murat Gurger Gokhan Once Erhan Yilmaz Sukru Demir Ilknur Calik Yakup Say Ahmet Kavakli Sefa Key Mustafa Umit Gurbuz Onur Bingollu |
| author_sort | Murat Gurger |
| collection | DOAJ |
| description | Abstract Background The aim of this study is to histologically and biomechanically investigate the effects of local PRP and ozone therapy (O2O3) on tendon-to-bone healing in a rabbit model of the supraspinatus tendon tear. Methods Four groups were formed to have seven rabbits in each group: repair, R; repair + PRP, RP; repair + ozone, RO; and repair + PRP + ozone, RPO. The supraspinatus tendon was detached by sharp dissection from the footprint and an acute tear pattern was created. Thereafter, tendon repair was performed with the transosseous technique. In the RP group, PRP, and in the RPO group, PRP + O2O3 mixture was injected to the tendon repair site. In the RO group, O2O3 gas mixture was injected into subacromial space three times a week for a total of 4 weeks. The study was ended at postoperative 6th week. Results When compared with the R group, a statistically significant increase was observed in the biomechanical strength of the RP and RPO groups. The highest increase in biomechanical strength was detected in the RPO group. The histology of the RO and RPO groups showed better collagen fiber continuity and orientation than the R and RP groups. Conclusions The results obtained from this study show that the ozonized PRP can be used as biological support to increase tendon-to-bone healing. However, these results need to be supported by clinical studies. |
| first_indexed | 2024-04-11T09:38:47Z |
| format | Article |
| id | doaj.art-63b0f0f17f6545448de340441e62361f |
| institution | Directory Open Access Journal |
| issn | 1749-799X |
| language | English |
| last_indexed | 2024-04-11T09:38:47Z |
| publishDate | 2021-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Orthopaedic Surgery and Research |
| spelling | doaj.art-63b0f0f17f6545448de340441e62361f2022-12-22T04:31:23ZengBMCJournal of Orthopaedic Surgery and Research1749-799X2021-03-011611910.1186/s13018-021-02320-wThe effect of the platelet-rich plasma and ozone therapy on tendon-to-bone healing in the rabbit rotator cuff repair modelMurat Gurger0Gokhan Once1Erhan Yilmaz2Sukru Demir3Ilknur Calik4Yakup Say5Ahmet Kavakli6Sefa Key7Mustafa Umit Gurbuz8Onur Bingollu9Department of Orthopaedics and Traumatology, Faculty of Medicine, Firat UniversityDepartment of Orthopaedics and Traumatology, Faculty of Medicine, Firat UniversityDepartment of Orthopaedics and Traumatology, Faculty of Medicine, Firat UniversityDepartment of Orthopaedics and Traumatology, Faculty of Medicine, Firat UniversityDepartment of Medical Pathology, Faculty of Medicine, Firat UniversityDepartment of Metallurgical and Materials Engineering, Tunceli UniversityDepartment of Anatomy, Faculty of Medicine, Firat UniversityDepartment of Orthopaedics and Traumatology, Faculty of Medicine, Firat UniversityDepartment of Orthopaedics and Traumatology, Faculty of Medicine, Firat UniversityDepartment of Orthopaedics and Traumatology, Faculty of Medicine, Firat UniversityAbstract Background The aim of this study is to histologically and biomechanically investigate the effects of local PRP and ozone therapy (O2O3) on tendon-to-bone healing in a rabbit model of the supraspinatus tendon tear. Methods Four groups were formed to have seven rabbits in each group: repair, R; repair + PRP, RP; repair + ozone, RO; and repair + PRP + ozone, RPO. The supraspinatus tendon was detached by sharp dissection from the footprint and an acute tear pattern was created. Thereafter, tendon repair was performed with the transosseous technique. In the RP group, PRP, and in the RPO group, PRP + O2O3 mixture was injected to the tendon repair site. In the RO group, O2O3 gas mixture was injected into subacromial space three times a week for a total of 4 weeks. The study was ended at postoperative 6th week. Results When compared with the R group, a statistically significant increase was observed in the biomechanical strength of the RP and RPO groups. The highest increase in biomechanical strength was detected in the RPO group. The histology of the RO and RPO groups showed better collagen fiber continuity and orientation than the R and RP groups. Conclusions The results obtained from this study show that the ozonized PRP can be used as biological support to increase tendon-to-bone healing. However, these results need to be supported by clinical studies.https://doi.org/10.1186/s13018-021-02320-wPlatelet-rich plasmaOzone therapyTendon-to-bone healingRotator cuff |
| spellingShingle | Murat Gurger Gokhan Once Erhan Yilmaz Sukru Demir Ilknur Calik Yakup Say Ahmet Kavakli Sefa Key Mustafa Umit Gurbuz Onur Bingollu The effect of the platelet-rich plasma and ozone therapy on tendon-to-bone healing in the rabbit rotator cuff repair model Journal of Orthopaedic Surgery and Research Platelet-rich plasma Ozone therapy Tendon-to-bone healing Rotator cuff |
| title | The effect of the platelet-rich plasma and ozone therapy on tendon-to-bone healing in the rabbit rotator cuff repair model |
| title_full | The effect of the platelet-rich plasma and ozone therapy on tendon-to-bone healing in the rabbit rotator cuff repair model |
| title_fullStr | The effect of the platelet-rich plasma and ozone therapy on tendon-to-bone healing in the rabbit rotator cuff repair model |
| title_full_unstemmed | The effect of the platelet-rich plasma and ozone therapy on tendon-to-bone healing in the rabbit rotator cuff repair model |
| title_short | The effect of the platelet-rich plasma and ozone therapy on tendon-to-bone healing in the rabbit rotator cuff repair model |
| title_sort | effect of the platelet rich plasma and ozone therapy on tendon to bone healing in the rabbit rotator cuff repair model |
| topic | Platelet-rich plasma Ozone therapy Tendon-to-bone healing Rotator cuff |
| url | https://doi.org/10.1186/s13018-021-02320-w |
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