Impact of ABO incompatible kidney transplantation on living donor transplantation.
BACKGROUND:ABO incompatible kidney transplantation (ABOi-KT) is an important approach for overcoming donor shortages. We evaluated the effect of ABOi-KT on living donor KT. METHODS:Two nationwide transplantation databases were used. We evaluated the impact of ABOi-KT on overall living donor transpla...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5360260?pdf=render |
| _version_ | 1819076549512527872 |
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| author | Ji Hyun Yu Byung Ha Chung Chul Woo Yang Korean Organ Transplantation Registry Study Group |
| author_facet | Ji Hyun Yu Byung Ha Chung Chul Woo Yang Korean Organ Transplantation Registry Study Group |
| author_sort | Ji Hyun Yu |
| collection | DOAJ |
| description | BACKGROUND:ABO incompatible kidney transplantation (ABOi-KT) is an important approach for overcoming donor shortages. We evaluated the effect of ABOi-KT on living donor KT. METHODS:Two nationwide transplantation databases were used. We evaluated the impact of ABOi-KT on overall living donor transplant activity and spousal donation as subgroup analysis. In addition, we compared the clinical outcome between ABOi-KT and ABO compatible KT (ABOc-KT) from spousal donor, and performed a Cox proportional hazards regression analysis to define the risk factors affecting the allograft outcomes. RESULT:The introduction of ABOi-KT increased overall living donor KT by 12.2% and its portion was increased from 0.3% to 21.7% during study period. The ABOi-KT in living unrelated KT was two times higher than that of living related donor KT (17.8 vs.9.8%). Spousal donor was a major portion of living unrelated KT (77.6%) and ABOi-KT increased spousal donation from 10% to 31.5% in living donor KT. In addition, increasing rate ABOi-KT from spousal donor was 10 times higher than that of living related donor. The clinical outcome (incidence of acute rejection, allograft function, and allograft and patient survival rates) of ABOi-KT from spousal donor was comparable to that of ABOc-KT. Neither ABO incompatibility nor spousal donor was associated with acute rejection or allograft failure on multivariate analysis. CONCLUSIONS:ABOi-KT increased overall living donor KT, and ABOi-KT from spousal donor is rapidly increasing with favorable clinical outcomes. |
| first_indexed | 2024-12-21T18:43:04Z |
| format | Article |
| id | doaj.art-63b1f4bf962449c8b860ee6ca321a326 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T18:43:04Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-63b1f4bf962449c8b860ee6ca321a3262022-12-21T18:53:58ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01123e017387810.1371/journal.pone.0173878Impact of ABO incompatible kidney transplantation on living donor transplantation.Ji Hyun YuByung Ha ChungChul Woo YangKorean Organ Transplantation Registry Study GroupBACKGROUND:ABO incompatible kidney transplantation (ABOi-KT) is an important approach for overcoming donor shortages. We evaluated the effect of ABOi-KT on living donor KT. METHODS:Two nationwide transplantation databases were used. We evaluated the impact of ABOi-KT on overall living donor transplant activity and spousal donation as subgroup analysis. In addition, we compared the clinical outcome between ABOi-KT and ABO compatible KT (ABOc-KT) from spousal donor, and performed a Cox proportional hazards regression analysis to define the risk factors affecting the allograft outcomes. RESULT:The introduction of ABOi-KT increased overall living donor KT by 12.2% and its portion was increased from 0.3% to 21.7% during study period. The ABOi-KT in living unrelated KT was two times higher than that of living related donor KT (17.8 vs.9.8%). Spousal donor was a major portion of living unrelated KT (77.6%) and ABOi-KT increased spousal donation from 10% to 31.5% in living donor KT. In addition, increasing rate ABOi-KT from spousal donor was 10 times higher than that of living related donor. The clinical outcome (incidence of acute rejection, allograft function, and allograft and patient survival rates) of ABOi-KT from spousal donor was comparable to that of ABOc-KT. Neither ABO incompatibility nor spousal donor was associated with acute rejection or allograft failure on multivariate analysis. CONCLUSIONS:ABOi-KT increased overall living donor KT, and ABOi-KT from spousal donor is rapidly increasing with favorable clinical outcomes.http://europepmc.org/articles/PMC5360260?pdf=render |
| spellingShingle | Ji Hyun Yu Byung Ha Chung Chul Woo Yang Korean Organ Transplantation Registry Study Group Impact of ABO incompatible kidney transplantation on living donor transplantation. PLoS ONE |
| title | Impact of ABO incompatible kidney transplantation on living donor transplantation. |
| title_full | Impact of ABO incompatible kidney transplantation on living donor transplantation. |
| title_fullStr | Impact of ABO incompatible kidney transplantation on living donor transplantation. |
| title_full_unstemmed | Impact of ABO incompatible kidney transplantation on living donor transplantation. |
| title_short | Impact of ABO incompatible kidney transplantation on living donor transplantation. |
| title_sort | impact of abo incompatible kidney transplantation on living donor transplantation |
| url | http://europepmc.org/articles/PMC5360260?pdf=render |
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