Obstetric and perinatal outcomes among pregnant women after influenza vaccination and after transferred respiratory infection
Objective. To examine a course of pregnancy, perinatal outcomes in pregnant women vaccinated against influenza and pregnant women who have had an acute respiratory infection (ARI). Material and methods. A comparative study of 108 pregnant women, vaccinated against influenza with vaccines Grippol® pl...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | Russian |
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IP Berlin A.V.
2015-08-01
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| Series: | Гинекология |
| Subjects: | |
| Online Access: | https://gynecology.orscience.ru/2079-5831/article/viewFile/28460/pdf |
| _version_ | 1811267563080908800 |
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| author | M P Kostinov A P Cherdantsev S S Semenova D A Tarbaeva A A Savisko O F Serova S A Iozefson N K Akhmatova T A Kostinova D A Praulova |
| author_facet | M P Kostinov A P Cherdantsev S S Semenova D A Tarbaeva A A Savisko O F Serova S A Iozefson N K Akhmatova T A Kostinova D A Praulova |
| author_sort | M P Kostinov |
| collection | DOAJ |
| description | Objective. To examine a course of pregnancy, perinatal outcomes in pregnant women vaccinated against influenza and pregnant women who have had an acute respiratory infection (ARI). Material and methods. A comparative study of 108 pregnant women, vaccinated against influenza with vaccines Grippol® plus and Agrippal S1, and 93 unvaccinated; as well as study of 185 pregnant women (50 of whom had experienced ARI during pregnancy, 135 - not) during the 2009-2010 influenza pandemic. Were applied clinical, instrumental, immunological, statistical methods. Results. It has been proven that immunization with inactivated subunit vaccines in the second and third trimester does not impact on the clinical course of pregnancy or the intrauterine growth of fetus. Respiratory infections result in increased frequency of obstetrics pathologies (subcompensated placental insufficiency 49.6%, chronic fetal hypoxia 49.6%, gestosis 35.5% and other). Adaptation in the early neonatal period among infants born to the vaccinated women is comparable to that of infants from the placebo group. The infants born to the women having a history of ARI were 3 times or more frequent to have impaired adaptation, grade I cerebral ischemia, neonatal hyperbilirubinemia. Conclusion. Vaccination of pregnant women in the II and III trimester of gestation with immunoadjuvant and unadjuvanted subunit influenza vaccine does not affect the course of pregnancy and the early neonatal period. |
| first_indexed | 2024-04-12T21:05:52Z |
| format | Article |
| id | doaj.art-63b1fb56c421496d8ce7bfca8b0e90fd |
| institution | Directory Open Access Journal |
| issn | 2079-5696 2079-5831 |
| language | Russian |
| last_indexed | 2024-04-12T21:05:52Z |
| publishDate | 2015-08-01 |
| publisher | IP Berlin A.V. |
| record_format | Article |
| series | Гинекология |
| spelling | doaj.art-63b1fb56c421496d8ce7bfca8b0e90fd2022-12-22T03:16:43ZrusIP Berlin A.V.Гинекология2079-56962079-58312015-08-01174434625590Obstetric and perinatal outcomes among pregnant women after influenza vaccination and after transferred respiratory infectionM P Kostinov0A P Cherdantsev1S S Semenova2D A Tarbaeva3A A Savisko4O F Serova5S A Iozefson6N K Akhmatova7T A Kostinova8D A Praulova9I.I.Mechnikov Research Institute of Vaccines and SeraUlyanovsk State UniversityCity Clinical Hospital №45 of the Department of Health of the Russian FederationChita State Medical AcademyRostov State Medical UniversityMoscow Regional Perinatal Center; A.I.Burnazyan Federal Medical Biophysical CenterChita State Medical AcademyI.I.Mechnikov Research Institute of Vaccines and SeraI.I.Mechnikov Research Institute of Vaccines and SeraDmitrii Rogachev Federal Research Center of Pediatric Hematology, Oncology and Immunology of the Ministry of Health of the Russian FederationObjective. To examine a course of pregnancy, perinatal outcomes in pregnant women vaccinated against influenza and pregnant women who have had an acute respiratory infection (ARI). Material and methods. A comparative study of 108 pregnant women, vaccinated against influenza with vaccines Grippol® plus and Agrippal S1, and 93 unvaccinated; as well as study of 185 pregnant women (50 of whom had experienced ARI during pregnancy, 135 - not) during the 2009-2010 influenza pandemic. Were applied clinical, instrumental, immunological, statistical methods. Results. It has been proven that immunization with inactivated subunit vaccines in the second and third trimester does not impact on the clinical course of pregnancy or the intrauterine growth of fetus. Respiratory infections result in increased frequency of obstetrics pathologies (subcompensated placental insufficiency 49.6%, chronic fetal hypoxia 49.6%, gestosis 35.5% and other). Adaptation in the early neonatal period among infants born to the vaccinated women is comparable to that of infants from the placebo group. The infants born to the women having a history of ARI were 3 times or more frequent to have impaired adaptation, grade I cerebral ischemia, neonatal hyperbilirubinemia. Conclusion. Vaccination of pregnant women in the II and III trimester of gestation with immunoadjuvant and unadjuvanted subunit influenza vaccine does not affect the course of pregnancy and the early neonatal period.https://gynecology.orscience.ru/2079-5831/article/viewFile/28460/pdfinfluenza vaccinevaccination during pregnancybirth outcomes in vaccinatedneonatal period |
| spellingShingle | M P Kostinov A P Cherdantsev S S Semenova D A Tarbaeva A A Savisko O F Serova S A Iozefson N K Akhmatova T A Kostinova D A Praulova Obstetric and perinatal outcomes among pregnant women after influenza vaccination and after transferred respiratory infection Гинекология influenza vaccine vaccination during pregnancy birth outcomes in vaccinated neonatal period |
| title | Obstetric and perinatal outcomes among pregnant women after influenza vaccination and after transferred respiratory infection |
| title_full | Obstetric and perinatal outcomes among pregnant women after influenza vaccination and after transferred respiratory infection |
| title_fullStr | Obstetric and perinatal outcomes among pregnant women after influenza vaccination and after transferred respiratory infection |
| title_full_unstemmed | Obstetric and perinatal outcomes among pregnant women after influenza vaccination and after transferred respiratory infection |
| title_short | Obstetric and perinatal outcomes among pregnant women after influenza vaccination and after transferred respiratory infection |
| title_sort | obstetric and perinatal outcomes among pregnant women after influenza vaccination and after transferred respiratory infection |
| topic | influenza vaccine vaccination during pregnancy birth outcomes in vaccinated neonatal period |
| url | https://gynecology.orscience.ru/2079-5831/article/viewFile/28460/pdf |
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