Functional Connectivity Between the Trigeminal Main Sensory Nucleus and the Trigeminal Motor Nucleus
The present study shows new evidence of functional connectivity between the trigeminal main sensory (NVsnpr) and motor (NVmt) nuclei in rats and mice. NVsnpr neurons projecting to NVmt are most highly concentrated in its dorsal half. Their electrical stimulation induced multiphasic excitatory synapt...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-06-01
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| Series: | Frontiers in Cellular Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fncel.2020.00167/full |
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| author | Mohammed Slaoui Hasnaoui Isabel Arsenault Dorly Verdier Sami Obeid Arlette Kolta Arlette Kolta |
| author_facet | Mohammed Slaoui Hasnaoui Isabel Arsenault Dorly Verdier Sami Obeid Arlette Kolta Arlette Kolta |
| author_sort | Mohammed Slaoui Hasnaoui |
| collection | DOAJ |
| description | The present study shows new evidence of functional connectivity between the trigeminal main sensory (NVsnpr) and motor (NVmt) nuclei in rats and mice. NVsnpr neurons projecting to NVmt are most highly concentrated in its dorsal half. Their electrical stimulation induced multiphasic excitatory synaptic responses in trigeminal MNs and evoked calcium responses mainly in the jaw-closing region of NVmt. Induction of rhythmic bursting in NVsnpr neurons by local applications of BAPTA also elicited rhythmic firing or clustering of postsynaptic potentials in trigeminal motoneurons, further emphasizing the functional relationship between these two nuclei in terms of rhythm transmission. Biocytin injections in both nuclei and calcium-imaging in one of the two nuclei during electrical stimulation of the other revealed a specific pattern of connectivity between the two nuclei, which organization seemed to critically depend on the dorsoventral location of the stimulation site within NVsnpr with the most dorsal areas of NVsnpr projecting to the dorsolateral region of NVmt and intermediate areas projecting to ventromedial NVmt. This study confirms and develops earlier experiments by exploring the physiological nature and functional topography of the connectivity between NVsnpr and NVmt that was demonstrated in the past with neuroanatomical techniques. |
| first_indexed | 2024-04-12T04:55:43Z |
| format | Article |
| id | doaj.art-63b4459a2d3a4f51b9513297bbd95e96 |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-04-12T04:55:43Z |
| publishDate | 2020-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-63b4459a2d3a4f51b9513297bbd95e962022-12-22T03:47:07ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022020-06-011410.3389/fncel.2020.00167542442Functional Connectivity Between the Trigeminal Main Sensory Nucleus and the Trigeminal Motor NucleusMohammed Slaoui Hasnaoui0Isabel Arsenault1Dorly Verdier2Sami Obeid3Arlette Kolta4Arlette Kolta5Groupe de Recherche sur le Systéme Nerveux Central, Département de Neurosciences, Faculté de Médecine, Université de Montréal, Montréeal, QC, CanadaGroupe de Recherche sur le Systéme Nerveux Central, Département de Neurosciences, Faculté de Médecine, Université de Montréal, Montréeal, QC, CanadaGroupe de Recherche sur le Systéme Nerveux Central, Département de Neurosciences, Faculté de Médecine, Université de Montréal, Montréeal, QC, CanadaGroupe de Recherche sur le Systéme Nerveux Central, Département de Neurosciences, Faculté de Médecine, Université de Montréal, Montréeal, QC, CanadaGroupe de Recherche sur le Systéme Nerveux Central, Département de Neurosciences, Faculté de Médecine, Université de Montréal, Montréeal, QC, CanadaDépartement de Stomatologie, Faculté de Médecine Dentaire, Université de Montreal, Montreal, QC, CanadaThe present study shows new evidence of functional connectivity between the trigeminal main sensory (NVsnpr) and motor (NVmt) nuclei in rats and mice. NVsnpr neurons projecting to NVmt are most highly concentrated in its dorsal half. Their electrical stimulation induced multiphasic excitatory synaptic responses in trigeminal MNs and evoked calcium responses mainly in the jaw-closing region of NVmt. Induction of rhythmic bursting in NVsnpr neurons by local applications of BAPTA also elicited rhythmic firing or clustering of postsynaptic potentials in trigeminal motoneurons, further emphasizing the functional relationship between these two nuclei in terms of rhythm transmission. Biocytin injections in both nuclei and calcium-imaging in one of the two nuclei during electrical stimulation of the other revealed a specific pattern of connectivity between the two nuclei, which organization seemed to critically depend on the dorsoventral location of the stimulation site within NVsnpr with the most dorsal areas of NVsnpr projecting to the dorsolateral region of NVmt and intermediate areas projecting to ventromedial NVmt. This study confirms and develops earlier experiments by exploring the physiological nature and functional topography of the connectivity between NVsnpr and NVmt that was demonstrated in the past with neuroanatomical techniques.https://www.frontiersin.org/article/10.3389/fncel.2020.00167/fullmasticationtrigeminalNVsnprNVmtmotoneuronsjaw muscles |
| spellingShingle | Mohammed Slaoui Hasnaoui Isabel Arsenault Dorly Verdier Sami Obeid Arlette Kolta Arlette Kolta Functional Connectivity Between the Trigeminal Main Sensory Nucleus and the Trigeminal Motor Nucleus Frontiers in Cellular Neuroscience mastication trigeminal NVsnpr NVmt motoneurons jaw muscles |
| title | Functional Connectivity Between the Trigeminal Main Sensory Nucleus and the Trigeminal Motor Nucleus |
| title_full | Functional Connectivity Between the Trigeminal Main Sensory Nucleus and the Trigeminal Motor Nucleus |
| title_fullStr | Functional Connectivity Between the Trigeminal Main Sensory Nucleus and the Trigeminal Motor Nucleus |
| title_full_unstemmed | Functional Connectivity Between the Trigeminal Main Sensory Nucleus and the Trigeminal Motor Nucleus |
| title_short | Functional Connectivity Between the Trigeminal Main Sensory Nucleus and the Trigeminal Motor Nucleus |
| title_sort | functional connectivity between the trigeminal main sensory nucleus and the trigeminal motor nucleus |
| topic | mastication trigeminal NVsnpr NVmt motoneurons jaw muscles |
| url | https://www.frontiersin.org/article/10.3389/fncel.2020.00167/full |
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