Insomniacs show greater prefrontal activation during verbal fluency task compared to non-insomniacs: a functional near-infrared spectroscopy investigation of depression in patients
Abstract Background Previous studies have shown that insomnia affects human prefrontal function and that there are specific patterns of brain activation to counteract sleep and improve cognition. However, the effects of insomnia on the prefrontal cortex of MDD (major depressive disorder) patients an...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-03-01
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| Series: | BMC Psychiatry |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12888-023-04694-z |
| _version_ | 1797853653204205568 |
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| author | HuaSen Xu YuXing Wang Yi Ming Wang YaQi Cao PeiFan Li YongXue Hu GuangYuan Xia |
| author_facet | HuaSen Xu YuXing Wang Yi Ming Wang YaQi Cao PeiFan Li YongXue Hu GuangYuan Xia |
| author_sort | HuaSen Xu |
| collection | DOAJ |
| description | Abstract Background Previous studies have shown that insomnia affects human prefrontal function and that there are specific patterns of brain activation to counteract sleep and improve cognition. However, the effects of insomnia on the prefrontal cortex of MDD (major depressive disorder) patients and the patterns of activation to counteract sleep in MDD patients remain unclear. The aim of this study is to examine this using fNIRS (functional near-infrared spectroscopy). Methods Eighty depressed patients and 44 healthy controls were recruited for this study. fNIRS was used to assess changes in the concentration of oxygenated hemoglobin ([oxy-Hb]) in the prefrontal cortex of all participants during the VFT (verbal fluency test) and to record the number of words created to assess cognitive ability. The Pittsburgh Sleep Quality Index was used to assess sleep quality, and the Hamilton Rating Scale for Depression (24-item) and Hamilton Rating Scale for Anxiety (14-item) were used to assess the severity of depression and anxiety. Results When comparing patients, the healthy control group had significantly higher [oxy-Hb] values in the bilateral prefrontal cortex during VFT than the MDD group. In the MDD group, the [oxy-Hb] values in all brain regions except the right DLPFC were significantly higher in the group with insomnia than in the group without insomnia, but their VFT performance was significantly lower than in the group without insomnia and the healthy group. PSQI scores were positively correlated with [oxy-Hb] values in some left-brain regions, whereas HAMD and HAMA scores were not correlated with [oxy-Hb] values. Conclusion The PFC was significantly less active during VFT in those with MDD than in healthy controls. All brain regions, except the right DLPFC, were significantly more active in MDD patients with insomnia than in those without insomnia, suggesting that sleep quality needs to be an important indicator in fNIRS screening. In addition, there was a positive correlation between the severity of insomnia in the left VLPFC and the level of activation, suggesting a role for the left brain region in the neurophysiology of overcoming sleepiness in MDD patients. these findings may provide new ideas for the treatment of MDD patients in the future. Trial registration Our experiment was registered in the China Clinical Trial Registry (registration number ChiCTR2200065622) on November 10.( The first patient was recruited in 10/11/2022.) |
| first_indexed | 2024-04-09T19:54:10Z |
| format | Article |
| id | doaj.art-63b4d989f5ea48c19a153d9da9ccd3dc |
| institution | Directory Open Access Journal |
| issn | 1471-244X |
| language | English |
| last_indexed | 2024-04-09T19:54:10Z |
| publishDate | 2023-03-01 |
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| record_format | Article |
| series | BMC Psychiatry |
| spelling | doaj.art-63b4d989f5ea48c19a153d9da9ccd3dc2023-04-03T05:35:47ZengBMCBMC Psychiatry1471-244X2023-03-0123111010.1186/s12888-023-04694-zInsomniacs show greater prefrontal activation during verbal fluency task compared to non-insomniacs: a functional near-infrared spectroscopy investigation of depression in patientsHuaSen Xu0YuXing Wang1Yi Ming Wang2YaQi Cao3PeiFan Li4YongXue Hu5GuangYuan Xia6Department of psychiatry, Affliated Hospital to Guizhou Medical UniversityDepartment of psychiatry, Affliated Hospital to Guizhou Medical UniversityDepartment of psychiatry, Affliated Hospital to Guizhou Medical UniversityDepartment of psychiatry, Affliated Hospital to Guizhou Medical UniversityDepartment of psychiatry, Affliated Hospital to Guizhou Medical UniversityDepartment of psychiatry, Affliated Hospital to Guizhou Medical UniversityDepartment of psychiatry, Affliated Hospital to Guizhou Medical UniversityAbstract Background Previous studies have shown that insomnia affects human prefrontal function and that there are specific patterns of brain activation to counteract sleep and improve cognition. However, the effects of insomnia on the prefrontal cortex of MDD (major depressive disorder) patients and the patterns of activation to counteract sleep in MDD patients remain unclear. The aim of this study is to examine this using fNIRS (functional near-infrared spectroscopy). Methods Eighty depressed patients and 44 healthy controls were recruited for this study. fNIRS was used to assess changes in the concentration of oxygenated hemoglobin ([oxy-Hb]) in the prefrontal cortex of all participants during the VFT (verbal fluency test) and to record the number of words created to assess cognitive ability. The Pittsburgh Sleep Quality Index was used to assess sleep quality, and the Hamilton Rating Scale for Depression (24-item) and Hamilton Rating Scale for Anxiety (14-item) were used to assess the severity of depression and anxiety. Results When comparing patients, the healthy control group had significantly higher [oxy-Hb] values in the bilateral prefrontal cortex during VFT than the MDD group. In the MDD group, the [oxy-Hb] values in all brain regions except the right DLPFC were significantly higher in the group with insomnia than in the group without insomnia, but their VFT performance was significantly lower than in the group without insomnia and the healthy group. PSQI scores were positively correlated with [oxy-Hb] values in some left-brain regions, whereas HAMD and HAMA scores were not correlated with [oxy-Hb] values. Conclusion The PFC was significantly less active during VFT in those with MDD than in healthy controls. All brain regions, except the right DLPFC, were significantly more active in MDD patients with insomnia than in those without insomnia, suggesting that sleep quality needs to be an important indicator in fNIRS screening. In addition, there was a positive correlation between the severity of insomnia in the left VLPFC and the level of activation, suggesting a role for the left brain region in the neurophysiology of overcoming sleepiness in MDD patients. these findings may provide new ideas for the treatment of MDD patients in the future. Trial registration Our experiment was registered in the China Clinical Trial Registry (registration number ChiCTR2200065622) on November 10.( The first patient was recruited in 10/11/2022.)https://doi.org/10.1186/s12888-023-04694-zMajor depressive disorderInsomniaPrefrontal cortexFunctionalNear-infrared spectroscopyVerbal fluency task |
| spellingShingle | HuaSen Xu YuXing Wang Yi Ming Wang YaQi Cao PeiFan Li YongXue Hu GuangYuan Xia Insomniacs show greater prefrontal activation during verbal fluency task compared to non-insomniacs: a functional near-infrared spectroscopy investigation of depression in patients BMC Psychiatry Major depressive disorder Insomnia Prefrontal cortex Functional Near-infrared spectroscopy Verbal fluency task |
| title | Insomniacs show greater prefrontal activation during verbal fluency task compared to non-insomniacs: a functional near-infrared spectroscopy investigation of depression in patients |
| title_full | Insomniacs show greater prefrontal activation during verbal fluency task compared to non-insomniacs: a functional near-infrared spectroscopy investigation of depression in patients |
| title_fullStr | Insomniacs show greater prefrontal activation during verbal fluency task compared to non-insomniacs: a functional near-infrared spectroscopy investigation of depression in patients |
| title_full_unstemmed | Insomniacs show greater prefrontal activation during verbal fluency task compared to non-insomniacs: a functional near-infrared spectroscopy investigation of depression in patients |
| title_short | Insomniacs show greater prefrontal activation during verbal fluency task compared to non-insomniacs: a functional near-infrared spectroscopy investigation of depression in patients |
| title_sort | insomniacs show greater prefrontal activation during verbal fluency task compared to non insomniacs a functional near infrared spectroscopy investigation of depression in patients |
| topic | Major depressive disorder Insomnia Prefrontal cortex Functional Near-infrared spectroscopy Verbal fluency task |
| url | https://doi.org/10.1186/s12888-023-04694-z |
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