Potentially Important Therapeutic Interactions between Antibiotics, and a Specially Engineered Emulsion Drug Vehicle Containing Krill-Oil-Based Phospholipids and Omega-3 Fatty Acids
The incidence of antimicrobial resistance (AMR) worldwide is increasing as the pipeline for the development of new chemotherapeutic entities is decreasing. Clearly, overexposure to antibiotics, including excessive dosing, is a key factor that fuels AMR. In fact, most of the new antibacterial agents...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-03-01
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| Series: | Antibiotics |
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| Online Access: | http://www.mdpi.com/2079-6382/7/1/22 |
| _version_ | 1819173270387163136 |
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| author | David F. Driscoll |
| author_facet | David F. Driscoll |
| author_sort | David F. Driscoll |
| collection | DOAJ |
| description | The incidence of antimicrobial resistance (AMR) worldwide is increasing as the pipeline for the development of new chemotherapeutic entities is decreasing. Clearly, overexposure to antibiotics, including excessive dosing, is a key factor that fuels AMR. In fact, most of the new antibacterial agents under development are derivatives of existing classes of antibiotics. Novel approaches involving unique antimicrobial combinations, targets, and/or delivery systems are under intense investigation. An innovative combination of active pharmaceutical ingredients (APIs) consisting of antimicrobial drug(s), krill-oil-based phospholipids, and omega-3 fatty acid triglycerides, that may extend the therapeutic viability of currently effective antibiotics, at least until new chemical entities are introduced, is described. |
| first_indexed | 2024-12-22T20:20:25Z |
| format | Article |
| id | doaj.art-63b5ec25d0164ab49de5acabd6865400 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-12-22T20:20:25Z |
| publishDate | 2018-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-63b5ec25d0164ab49de5acabd68654002022-12-21T18:13:52ZengMDPI AGAntibiotics2079-63822018-03-01712210.3390/antibiotics7010022antibiotics7010022Potentially Important Therapeutic Interactions between Antibiotics, and a Specially Engineered Emulsion Drug Vehicle Containing Krill-Oil-Based Phospholipids and Omega-3 Fatty AcidsDavid F. Driscoll0Stable Solutions LLC, Goleta, CA 93117, USAThe incidence of antimicrobial resistance (AMR) worldwide is increasing as the pipeline for the development of new chemotherapeutic entities is decreasing. Clearly, overexposure to antibiotics, including excessive dosing, is a key factor that fuels AMR. In fact, most of the new antibacterial agents under development are derivatives of existing classes of antibiotics. Novel approaches involving unique antimicrobial combinations, targets, and/or delivery systems are under intense investigation. An innovative combination of active pharmaceutical ingredients (APIs) consisting of antimicrobial drug(s), krill-oil-based phospholipids, and omega-3 fatty acid triglycerides, that may extend the therapeutic viability of currently effective antibiotics, at least until new chemical entities are introduced, is described.http://www.mdpi.com/2079-6382/7/1/22β-lactam antibioticsβ-lactamase inhibitorskrill oil phospholipidsomega-3 fatty acid triglyceridesantimicrobial resistance |
| spellingShingle | David F. Driscoll Potentially Important Therapeutic Interactions between Antibiotics, and a Specially Engineered Emulsion Drug Vehicle Containing Krill-Oil-Based Phospholipids and Omega-3 Fatty Acids Antibiotics β-lactam antibiotics β-lactamase inhibitors krill oil phospholipids omega-3 fatty acid triglycerides antimicrobial resistance |
| title | Potentially Important Therapeutic Interactions between Antibiotics, and a Specially Engineered Emulsion Drug Vehicle Containing Krill-Oil-Based Phospholipids and Omega-3 Fatty Acids |
| title_full | Potentially Important Therapeutic Interactions between Antibiotics, and a Specially Engineered Emulsion Drug Vehicle Containing Krill-Oil-Based Phospholipids and Omega-3 Fatty Acids |
| title_fullStr | Potentially Important Therapeutic Interactions between Antibiotics, and a Specially Engineered Emulsion Drug Vehicle Containing Krill-Oil-Based Phospholipids and Omega-3 Fatty Acids |
| title_full_unstemmed | Potentially Important Therapeutic Interactions between Antibiotics, and a Specially Engineered Emulsion Drug Vehicle Containing Krill-Oil-Based Phospholipids and Omega-3 Fatty Acids |
| title_short | Potentially Important Therapeutic Interactions between Antibiotics, and a Specially Engineered Emulsion Drug Vehicle Containing Krill-Oil-Based Phospholipids and Omega-3 Fatty Acids |
| title_sort | potentially important therapeutic interactions between antibiotics and a specially engineered emulsion drug vehicle containing krill oil based phospholipids and omega 3 fatty acids |
| topic | β-lactam antibiotics β-lactamase inhibitors krill oil phospholipids omega-3 fatty acid triglycerides antimicrobial resistance |
| url | http://www.mdpi.com/2079-6382/7/1/22 |
| work_keys_str_mv | AT davidfdriscoll potentiallyimportanttherapeuticinteractionsbetweenantibioticsandaspeciallyengineeredemulsiondrugvehiclecontainingkrilloilbasedphospholipidsandomega3fattyacids |