The first 24-hour bilirubin level as a predictor of hyperbilirubinemia in healthy term newborns
Background Early discharging healthy term newborns results in a difficulty to recognize hyperbilirubinemia. Objective The aim of this study was to determine the value of the first 24-hour total and unbound bilirubin levels in predicting hyper- bilirubinemia in healthy term newborns. Methods The firs...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Indonesian Pediatric Society Publishing House
2016-10-01
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| Series: | Paediatrica Indonesiana |
| Subjects: | |
| Online Access: | https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/667 |
| Summary: | Background Early discharging healthy term newborns results in
a difficulty to recognize hyperbilirubinemia.
Objective The aim of this study was to determine the value of the
first 24-hour total and unbound bilirubin levels in predicting hyper-
bilirubinemia in healthy term newborns.
Methods The first 24-hour and the 5 th day total and unbound
bilirubin levels were measured in 84 healthy term newborns. The
total bilirubin level was measured spectrophotometrically, whereas
unbound bilirubin level was determined by peroxidase-oxidation
method. Hyperbilirubinemia was defined as serum total bilirubin of
>12.9 mg/dL or serum unbound bilirubin of >0.5 mg/dL after 24
hours of life.
Results A correlation between the first 24-hour and the 5 th day
total bilirubin levels was found (r= 0.53) with a regression equa-
tion: Y (total bilirubin on day 5) = 4.69 + 1.15X (total bilirubin in the
first 24 hours). In unbound bilirubin (r=0.31), the regression equa-
tion was Y (unbound bilirubin on day 5) = 0.13 + 0.95X (unbound
bilirubin in the first 24-hours). The relative risk for developing hy-
perbilirubinemia in newborns whose TB 1 was >4.5 mg/dL was 12
(95% CI 2.9;48.4), whereas newborns whose UB 1 was >0.09 mg/
dL was 9.5 (95% CI 1.2;77.4).
Conclusion Total bilirubin level of >4.5 mg/dL in the first 24 hours
can predict the development of hyperbilirubinemia in term new-
borns in the first week of life. Newborns with such level of total
bilirubin need a longer stay or should visit the hospital on day 5-7 |
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| ISSN: | 0030-9311 2338-476X |