Age-related deregulation of TDP-43 after stroke enhances NF-κB-mediated inflammation and neuronal damage

Age-related deregulation of TDP-43 after stroke enhances NF-κB-mediated inflammation and neuronal damage

Abstract Background TDP-43 has been identified as a disease-associated protein in several chronic neurodegenerative disorders and increasing evidence suggests its potentially pathogenic role following brain injuries. Normally expressed in nucleus, under pathological conditions TDP-43 forms cytoplasm...

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Bibliographic Details
Main Authors: Sai Sampath Thammisetty, Jordi Pedragosa, Yuan Cheng Weng, Frédéric Calon, Anna Planas, Jasna Kriz
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Journal of Neuroinflammation
Subjects:
Post-stroke inflammation
Aging
Acute neurodegeneration
Microglia
Innate immune response
Neuronal injury
Online Access:http://link.springer.com/article/10.1186/s12974-018-1350-y

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http://link.springer.com/article/10.1186/s12974-018-1350-y

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