Tracking changes of individual cortical pores over 1 year via HR-pQCT in a small cohort of 60-year-old females
Introduction: High-resolution peripheral quantitative computed tomography (HR-pQCT) is a powerful tool that has revolutionized 3D longitudinal assessment of bone microarchitecture. However, cortical porosity, a common characteristic of cortical bone loss, is still often determined by static evaluati...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Bone Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352187222004673 |
| _version_ | 1811201973722021888 |
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| author | Rachel K. Surowiec Elizabeth A. Swallow Stuart J. Warden Matthew R. Allen |
| author_facet | Rachel K. Surowiec Elizabeth A. Swallow Stuart J. Warden Matthew R. Allen |
| author_sort | Rachel K. Surowiec |
| collection | DOAJ |
| description | Introduction: High-resolution peripheral quantitative computed tomography (HR-pQCT) is a powerful tool that has revolutionized 3D longitudinal assessment of bone microarchitecture. However, cortical porosity, a common characteristic of cortical bone loss, is still often determined by static evaluation of overall porosity at one timepoint. Therefore, we sought to 1) describe a technique to evaluate individual cortical pore dynamics in aging females over one year using HR-pQCT imaging and 2) determine whether formation and expansion of pores would exceed contraction and infilling of pores. Methods: HR-pQCT (60.7 μm resolution) images were acquired one year apart at the distal tibia and distal radius in seven female volunteers (60–72 years of age). Baseline and one-year images were registered at each bone site and a custom software was used to quantify dynamic activity of individual cortical pores using the following categories: developed, infilled, expanded, contracted, and static. Results: Over the one-year period, cortical pores actively developed, contracted, expanded, and infilled. More pores expanded and developed vs. infilled or contracted leading to increased pore area in both tibial and radial sites (p = 0.0034 and p = 0.0474, respectively). Closed pores in the tibia, those that were not connected to the endosteal or periosteal surfaces, were the most dynamic of any pores type (open/closed) at either bone site. Conclusion: This study demonstrates an approach to longitudinally track individual cortical pore activity in tibial and radial sites. These data expand conventional parameters for assessing cortical porosity and show increased porosity in one year of aging is caused by newly developed pores and expansion of existing pores. |
| first_indexed | 2024-04-12T02:32:05Z |
| format | Article |
| id | doaj.art-63b7db7abd6944ccbf5a8c1e158d18f9 |
| institution | Directory Open Access Journal |
| issn | 2352-1872 |
| language | English |
| last_indexed | 2024-04-12T02:32:05Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Bone Reports |
| spelling | doaj.art-63b7db7abd6944ccbf5a8c1e158d18f92022-12-22T03:51:45ZengElsevierBone Reports2352-18722022-12-0117101633Tracking changes of individual cortical pores over 1 year via HR-pQCT in a small cohort of 60-year-old femalesRachel K. Surowiec0Elizabeth A. Swallow1Stuart J. Warden2Matthew R. Allen3Department of Anatomy, Cell Biology & Physiology, Indiana University School of Medicine, Indianapolis, IN, United States; Department of Biomedical Engineering, Indiana University–Purdue University Indianapolis, Indianapolis, IN, United StatesDepartment of Anatomy, Cell Biology & Physiology, Indiana University School of Medicine, Indianapolis, IN, United StatesDepartment of Physical Therapy, School of Health & Human Sciences, Indiana University School of Medicine, Indianapolis, IN, United StatesDepartment of Anatomy, Cell Biology & Physiology, Indiana University School of Medicine, Indianapolis, IN, United States; Roudebush Veterans Administration Medical Center, Indianapolis, IN, United States; Corresponding author at: Dept. of Anatomy and Cell Biology, MS 5035, Indiana University School of Medicine, 635 Barnhill Dr., Indianapolis, IN 46202, United States.Introduction: High-resolution peripheral quantitative computed tomography (HR-pQCT) is a powerful tool that has revolutionized 3D longitudinal assessment of bone microarchitecture. However, cortical porosity, a common characteristic of cortical bone loss, is still often determined by static evaluation of overall porosity at one timepoint. Therefore, we sought to 1) describe a technique to evaluate individual cortical pore dynamics in aging females over one year using HR-pQCT imaging and 2) determine whether formation and expansion of pores would exceed contraction and infilling of pores. Methods: HR-pQCT (60.7 μm resolution) images were acquired one year apart at the distal tibia and distal radius in seven female volunteers (60–72 years of age). Baseline and one-year images were registered at each bone site and a custom software was used to quantify dynamic activity of individual cortical pores using the following categories: developed, infilled, expanded, contracted, and static. Results: Over the one-year period, cortical pores actively developed, contracted, expanded, and infilled. More pores expanded and developed vs. infilled or contracted leading to increased pore area in both tibial and radial sites (p = 0.0034 and p = 0.0474, respectively). Closed pores in the tibia, those that were not connected to the endosteal or periosteal surfaces, were the most dynamic of any pores type (open/closed) at either bone site. Conclusion: This study demonstrates an approach to longitudinally track individual cortical pore activity in tibial and radial sites. These data expand conventional parameters for assessing cortical porosity and show increased porosity in one year of aging is caused by newly developed pores and expansion of existing pores.http://www.sciencedirect.com/science/article/pii/S2352187222004673High resolution peripheral quantitative computed tomography (HR-pQCT)Cortical porosityPore trackingBone |
| spellingShingle | Rachel K. Surowiec Elizabeth A. Swallow Stuart J. Warden Matthew R. Allen Tracking changes of individual cortical pores over 1 year via HR-pQCT in a small cohort of 60-year-old females Bone Reports High resolution peripheral quantitative computed tomography (HR-pQCT) Cortical porosity Pore tracking Bone |
| title | Tracking changes of individual cortical pores over 1 year via HR-pQCT in a small cohort of 60-year-old females |
| title_full | Tracking changes of individual cortical pores over 1 year via HR-pQCT in a small cohort of 60-year-old females |
| title_fullStr | Tracking changes of individual cortical pores over 1 year via HR-pQCT in a small cohort of 60-year-old females |
| title_full_unstemmed | Tracking changes of individual cortical pores over 1 year via HR-pQCT in a small cohort of 60-year-old females |
| title_short | Tracking changes of individual cortical pores over 1 year via HR-pQCT in a small cohort of 60-year-old females |
| title_sort | tracking changes of individual cortical pores over 1 year via hr pqct in a small cohort of 60 year old females |
| topic | High resolution peripheral quantitative computed tomography (HR-pQCT) Cortical porosity Pore tracking Bone |
| url | http://www.sciencedirect.com/science/article/pii/S2352187222004673 |
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