Diagnostic Value of Diffusion-Weighted Imaging with Background Body Signal Suppression (DWIBS) for the Pre-Therapeutic Loco-Regional Staging of Cervical Cancer: A Feasibility and Interobserver Reliability Study
(1) Background: cervical cancer is one of the leading causes of cancer-related deaths and the fourth most common cancer among women worldwide. Magnetic resonance imaging (MRI) is the modality of choice for loco-regional staging of cervical cancer in the primary diagnostic workup beginning with at le...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Current Oncology |
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| Online Access: | https://www.mdpi.com/1718-7729/30/1/89 |
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| author | Stephan Schleder Matthias May Carsten Scholz Johannes Dinkel Quirin Strotzer Ingo Einspieler Marco Dollinger Andreas G. Schreyer Jochen Grassinger Andreas Schicho |
| author_facet | Stephan Schleder Matthias May Carsten Scholz Johannes Dinkel Quirin Strotzer Ingo Einspieler Marco Dollinger Andreas G. Schreyer Jochen Grassinger Andreas Schicho |
| author_sort | Stephan Schleder |
| collection | DOAJ |
| description | (1) Background: cervical cancer is one of the leading causes of cancer-related deaths and the fourth most common cancer among women worldwide. Magnetic resonance imaging (MRI) is the modality of choice for loco-regional staging of cervical cancer in the primary diagnostic workup beginning with at least stage IB. (2) Methods: we retrospectively analyzed 16 patients with histopathological proven cervical cancer (FIGO IB1–IVA) for the diagnostic accuracy of standard MRI and standard MRI with diffusion-weighted imaging with background body signal suppression (DWIBS) for the correct pre-therapeutic assessment of the definite FIGO category. (3) Results: In 7 out of 32 readings (22%), DWIBS improved diagnostic accuracy. With DWIBS, four (13%) additional readings were assigned the correct major (I–IV) FIGO stages pre-therapeutically. Interobserver reliability of DWIBS was weakest for parametrial infiltration (k = 0.43; CI-95% 0.00–1.00) and perfect for tumor size <2 cm, infiltration of the vaginal lower third, infiltration of adjacent organs and loco-regional nodal metastases (k = 1.000; CI-95% 1.00–1.00). (4) Conclusions: the pre-therapeutic staging of cervical cancer has a high diagnostic accuracy and interobserver reliability when using standard MRI but can be further optimized with the addition of DWIBS sequences when reporting is performed by an experienced radiologist. |
| first_indexed | 2024-03-09T13:04:43Z |
| format | Article |
| id | doaj.art-63b877414e764a8aba1187b8841b88a3 |
| institution | Directory Open Access Journal |
| issn | 1198-0052 1718-7729 |
| language | English |
| last_indexed | 2024-03-09T13:04:43Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj.art-63b877414e764a8aba1187b8841b88a32023-11-30T21:50:07ZengMDPI AGCurrent Oncology1198-00521718-77292023-01-013011164117310.3390/curroncol30010089Diagnostic Value of Diffusion-Weighted Imaging with Background Body Signal Suppression (DWIBS) for the Pre-Therapeutic Loco-Regional Staging of Cervical Cancer: A Feasibility and Interobserver Reliability StudyStephan Schleder0Matthias May1Carsten Scholz2Johannes Dinkel3Quirin Strotzer4Ingo Einspieler5Marco Dollinger6Andreas G. Schreyer7Jochen Grassinger8Andreas Schicho9Department of Diagnostic and Interventional Radiology, Merciful Brothers Hospital St. Elisabeth, 94315 Straubing, GermanyDepartment of Urology, Merciful Brothers Hospital St. Elisabeth, 94315 Straubing, GermanyDepartment of Gynecology and Obstetrics, Merciful Brothers Hospital St. Elisabeth, 94315 Straubing, GermanyDepartment of Radiology, University Medical Center Regensburg, 93055 Regensburg, GermanyDepartment of Radiology, University Medical Center Regensburg, 93055 Regensburg, GermanyDepartment of Radiology, University Medical Center Regensburg, 93055 Regensburg, GermanyDepartment of Radiology, University Medical Center Regensburg, 93055 Regensburg, GermanyDepartment of Diagnostic and Interventional Radiology, University Hospital Brandenburg, Brandenburg Medical School Theodor Fontane, 14770 Brandenburg, GermanyDepartment of Hematology and Oncology, Merciful Brothers Hospital St. Elisabeth, 94315 Straubing, GermanyDepartment of Radiology, University Medical Center Regensburg, 93055 Regensburg, Germany(1) Background: cervical cancer is one of the leading causes of cancer-related deaths and the fourth most common cancer among women worldwide. Magnetic resonance imaging (MRI) is the modality of choice for loco-regional staging of cervical cancer in the primary diagnostic workup beginning with at least stage IB. (2) Methods: we retrospectively analyzed 16 patients with histopathological proven cervical cancer (FIGO IB1–IVA) for the diagnostic accuracy of standard MRI and standard MRI with diffusion-weighted imaging with background body signal suppression (DWIBS) for the correct pre-therapeutic assessment of the definite FIGO category. (3) Results: In 7 out of 32 readings (22%), DWIBS improved diagnostic accuracy. With DWIBS, four (13%) additional readings were assigned the correct major (I–IV) FIGO stages pre-therapeutically. Interobserver reliability of DWIBS was weakest for parametrial infiltration (k = 0.43; CI-95% 0.00–1.00) and perfect for tumor size <2 cm, infiltration of the vaginal lower third, infiltration of adjacent organs and loco-regional nodal metastases (k = 1.000; CI-95% 1.00–1.00). (4) Conclusions: the pre-therapeutic staging of cervical cancer has a high diagnostic accuracy and interobserver reliability when using standard MRI but can be further optimized with the addition of DWIBS sequences when reporting is performed by an experienced radiologist.https://www.mdpi.com/1718-7729/30/1/89MRIDWIBScervical cancerstaging |
| spellingShingle | Stephan Schleder Matthias May Carsten Scholz Johannes Dinkel Quirin Strotzer Ingo Einspieler Marco Dollinger Andreas G. Schreyer Jochen Grassinger Andreas Schicho Diagnostic Value of Diffusion-Weighted Imaging with Background Body Signal Suppression (DWIBS) for the Pre-Therapeutic Loco-Regional Staging of Cervical Cancer: A Feasibility and Interobserver Reliability Study Current Oncology MRI DWIBS cervical cancer staging |
| title | Diagnostic Value of Diffusion-Weighted Imaging with Background Body Signal Suppression (DWIBS) for the Pre-Therapeutic Loco-Regional Staging of Cervical Cancer: A Feasibility and Interobserver Reliability Study |
| title_full | Diagnostic Value of Diffusion-Weighted Imaging with Background Body Signal Suppression (DWIBS) for the Pre-Therapeutic Loco-Regional Staging of Cervical Cancer: A Feasibility and Interobserver Reliability Study |
| title_fullStr | Diagnostic Value of Diffusion-Weighted Imaging with Background Body Signal Suppression (DWIBS) for the Pre-Therapeutic Loco-Regional Staging of Cervical Cancer: A Feasibility and Interobserver Reliability Study |
| title_full_unstemmed | Diagnostic Value of Diffusion-Weighted Imaging with Background Body Signal Suppression (DWIBS) for the Pre-Therapeutic Loco-Regional Staging of Cervical Cancer: A Feasibility and Interobserver Reliability Study |
| title_short | Diagnostic Value of Diffusion-Weighted Imaging with Background Body Signal Suppression (DWIBS) for the Pre-Therapeutic Loco-Regional Staging of Cervical Cancer: A Feasibility and Interobserver Reliability Study |
| title_sort | diagnostic value of diffusion weighted imaging with background body signal suppression dwibs for the pre therapeutic loco regional staging of cervical cancer a feasibility and interobserver reliability study |
| topic | MRI DWIBS cervical cancer staging |
| url | https://www.mdpi.com/1718-7729/30/1/89 |
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