Lymphoplasmacytic lymphoma and marginal zone lymphoma involving bone marrow: A diagnostic dilemma. Useful clinicopathological features to accurate the diagnosis
Abstract Lymphoplasmacytic lymphoma (LPL) and marginal zone lymphoma (MZL) frequently infiltrate the bone marrow with similar histologic and immunohistochemical characteristics posing diagnostic problems. Bone marrow biopsy specimens from 25 LPL and 16 MZL have been studied, correlating with clinica...
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| Format: | Article |
| Language: | English |
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Wiley
2022-11-01
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| Series: | eJHaem |
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| Online Access: | https://doi.org/10.1002/jha2.573 |
| _version_ | 1827800305053466624 |
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| author | Patricia García‐Abellás Ana Ferrer Gómez Diego Bueno Sacristán Miguel Piris Villaespesa María Talavera Yagüe María Eugenia Reguero Callejas Mónica García‐Cosío |
| author_facet | Patricia García‐Abellás Ana Ferrer Gómez Diego Bueno Sacristán Miguel Piris Villaespesa María Talavera Yagüe María Eugenia Reguero Callejas Mónica García‐Cosío |
| author_sort | Patricia García‐Abellás |
| collection | DOAJ |
| description | Abstract Lymphoplasmacytic lymphoma (LPL) and marginal zone lymphoma (MZL) frequently infiltrate the bone marrow with similar histologic and immunohistochemical characteristics posing diagnostic problems. Bone marrow biopsy specimens from 25 LPL and 16 MZL have been studied, correlating with clinical, laboratory parameters and the MYD88_p.L265P mutation. Paratrabecular and interstitial infiltration pattern, serum IgM paraprotein levels, and MYD88_p.L265P mutation were significantly more frequent in LPL. Nodular or intrasinusoidal pattern with lymphocytosis and splenomegaly were associated with MZL diagnosis. Different clinical and histological parameters should be collected when LPL or MZL is suspected in bone marrow biopsy specimens. |
| first_indexed | 2024-03-11T20:06:25Z |
| format | Article |
| id | doaj.art-63b8b6b532eb4cd1bc5fe350507ad6ea |
| institution | Directory Open Access Journal |
| issn | 2688-6146 |
| language | English |
| last_indexed | 2024-03-11T20:06:25Z |
| publishDate | 2022-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | eJHaem |
| spelling | doaj.art-63b8b6b532eb4cd1bc5fe350507ad6ea2023-10-03T16:50:47ZengWileyeJHaem2688-61462022-11-01341181118710.1002/jha2.573Lymphoplasmacytic lymphoma and marginal zone lymphoma involving bone marrow: A diagnostic dilemma. Useful clinicopathological features to accurate the diagnosisPatricia García‐Abellás0Ana Ferrer Gómez1Diego Bueno Sacristán2Miguel Piris Villaespesa3María Talavera Yagüe4María Eugenia Reguero Callejas5Mónica García‐Cosío6Department of Pathology Ramón y Cajal Universitary Hospital Madrid SpainDepartment of Pathology Ramón y Cajal Universitary Hospital Madrid SpainDepartment of Pathology Ramón y Cajal Universitary Hospital Madrid SpainDepartment of Hematology Ramón y Cajal Universitary Hospital Madrid SpainDepartment of Genetics Ramón y Cajal Universitary Hospital Madrid SpainDepartment of Pathology Ramón y Cajal Universitary Hospital Madrid SpainHead of Hematopathology Department Ramón y Cajal Universitary Hospital; Alcalá University, Madrid, Spain; Instituto Ramon y Cajal de Investigacion Sanitaria, Madrid, Spain; CIBERONC Madrid SpainAbstract Lymphoplasmacytic lymphoma (LPL) and marginal zone lymphoma (MZL) frequently infiltrate the bone marrow with similar histologic and immunohistochemical characteristics posing diagnostic problems. Bone marrow biopsy specimens from 25 LPL and 16 MZL have been studied, correlating with clinical, laboratory parameters and the MYD88_p.L265P mutation. Paratrabecular and interstitial infiltration pattern, serum IgM paraprotein levels, and MYD88_p.L265P mutation were significantly more frequent in LPL. Nodular or intrasinusoidal pattern with lymphocytosis and splenomegaly were associated with MZL diagnosis. Different clinical and histological parameters should be collected when LPL or MZL is suspected in bone marrow biopsy specimens.https://doi.org/10.1002/jha2.573bone marrowdiagnosislymphoplasmacytic lymphomamarginal zone lymphomaWaldenström macroglobulinemia |
| spellingShingle | Patricia García‐Abellás Ana Ferrer Gómez Diego Bueno Sacristán Miguel Piris Villaespesa María Talavera Yagüe María Eugenia Reguero Callejas Mónica García‐Cosío Lymphoplasmacytic lymphoma and marginal zone lymphoma involving bone marrow: A diagnostic dilemma. Useful clinicopathological features to accurate the diagnosis eJHaem bone marrow diagnosis lymphoplasmacytic lymphoma marginal zone lymphoma Waldenström macroglobulinemia |
| title | Lymphoplasmacytic lymphoma and marginal zone lymphoma involving bone marrow: A diagnostic dilemma. Useful clinicopathological features to accurate the diagnosis |
| title_full | Lymphoplasmacytic lymphoma and marginal zone lymphoma involving bone marrow: A diagnostic dilemma. Useful clinicopathological features to accurate the diagnosis |
| title_fullStr | Lymphoplasmacytic lymphoma and marginal zone lymphoma involving bone marrow: A diagnostic dilemma. Useful clinicopathological features to accurate the diagnosis |
| title_full_unstemmed | Lymphoplasmacytic lymphoma and marginal zone lymphoma involving bone marrow: A diagnostic dilemma. Useful clinicopathological features to accurate the diagnosis |
| title_short | Lymphoplasmacytic lymphoma and marginal zone lymphoma involving bone marrow: A diagnostic dilemma. Useful clinicopathological features to accurate the diagnosis |
| title_sort | lymphoplasmacytic lymphoma and marginal zone lymphoma involving bone marrow a diagnostic dilemma useful clinicopathological features to accurate the diagnosis |
| topic | bone marrow diagnosis lymphoplasmacytic lymphoma marginal zone lymphoma Waldenström macroglobulinemia |
| url | https://doi.org/10.1002/jha2.573 |
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