Early Renal Involvement in Cats with Natural Feline Morbillivirus Infection
Feline morbillivirus (FeMV) is a newly discovered paramyxovirus infecting domestic cats and its role in the pathogenesis of feline chronic kidney disease (CKD) has been suggested, however not confirmed. The primary aim of the study was to evaluate the renal damage associated with FeMV infection in c...
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MDPI AG
2020-05-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/10/5/828 |
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| author | Paolo Emidio Crisi Francesco Dondi Eliana De Luca Morena Di Tommaso Kateryna Vasylyeva Enea Ferlizza Giovanni Savini Alessia Luciani Daniela Malatesta Alessio Lorusso Andrea Boari |
| author_facet | Paolo Emidio Crisi Francesco Dondi Eliana De Luca Morena Di Tommaso Kateryna Vasylyeva Enea Ferlizza Giovanni Savini Alessia Luciani Daniela Malatesta Alessio Lorusso Andrea Boari |
| author_sort | Paolo Emidio Crisi |
| collection | DOAJ |
| description | Feline morbillivirus (FeMV) is a newly discovered paramyxovirus infecting domestic cats and its role in the pathogenesis of feline chronic kidney disease (CKD) has been suggested, however not confirmed. The primary aim of the study was to evaluate the renal damage associated with FeMV infection in cats. In this retrospective study, clinical and clinicopathological data were compared among 14 FeMV naturally infected, 21 CKD and 22 healthy cats. FeMV positive cats had serum chemistry analytes and main urine chemistry results similar to the healthy subjects. FeMV positive cats had significantly decreased urine specific gravity (median 1054, range 1022–1065) and urine creatinine (median 227.23 mg/dL, range 83.02–489.75) when compared with healthy cats (median 1067, range 1040–1080, <i>p</i> < 0.001; median 406.50 mg/dL, range 195.32–575.58; <i>p</i> < 0.001, respectively). Urine protein:creatinine ratio (UPC) results of FeMV and CKD were not different (median 0.20, range 0.08–1.03; median 0.23, range 0.10–0.80, respectively), however UPC results were significantly increased in both groups, if compared with healthy cats (median 0.1, range 0.04–0.250, <i>p</i> < 0.01). Based on clinical data, serum creatinine concentration, urine specific gravity and UPC results, CKD was suspected by clinicians in 3/14 FeMV cats. Urine protein sodium-dodecyl-sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) in 10/13 (77%) FeMV cats indicated a tubular pattern, with a decrease of uromodulin and an increase in the number and intensity of low molecular weight proteins. FeMV infection can be associated with different grades of renal dysfunction ranging from mild tubular proteinuria with less concentrated urine to azotemia in cats younger than those typically affected by CKD. |
| first_indexed | 2024-03-10T19:55:29Z |
| format | Article |
| id | doaj.art-63b93e438cae44d1a7f32559708343dd |
| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-10T19:55:29Z |
| publishDate | 2020-05-01 |
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| record_format | Article |
| series | Animals |
| spelling | doaj.art-63b93e438cae44d1a7f32559708343dd2023-11-19T23:59:49ZengMDPI AGAnimals2076-26152020-05-0110582810.3390/ani10050828Early Renal Involvement in Cats with Natural Feline Morbillivirus InfectionPaolo Emidio Crisi0Francesco Dondi1Eliana De Luca2Morena Di Tommaso3Kateryna Vasylyeva4Enea Ferlizza5Giovanni Savini6Alessia Luciani7Daniela Malatesta8Alessio Lorusso9Andrea Boari10Faculty of Veterinary Medicine, Veterinary University Hospital, University of Teramo, Località Piano d’Accio, 64100 Teramo, ItalyDepartment of Veterinary Medical Sciences, Alma Mater Studiorum-University of Bologna, Via Tolara di Sopra 50, 40064 Ozzano dell’Emilia (BO), ItalyFaculty of Veterinary Medicine, Veterinary University Hospital, University of Teramo, Località Piano d’Accio, 64100 Teramo, ItalyFaculty of Veterinary Medicine, Veterinary University Hospital, University of Teramo, Località Piano d’Accio, 64100 Teramo, ItalyDepartment of Veterinary Medical Sciences, Alma Mater Studiorum-University of Bologna, Via Tolara di Sopra 50, 40064 Ozzano dell’Emilia (BO), ItalyDepartment of Veterinary Medical Sciences, Alma Mater Studiorum-University of Bologna, Via Tolara di Sopra 50, 40064 Ozzano dell’Emilia (BO), ItalyIstituto Zooprofilattico Sperimentale dell’Abruzzo e del Molise (IZSAM), Campo Boario, 64100 Teramo, ItalyFaculty of Veterinary Medicine, Veterinary University Hospital, University of Teramo, Località Piano d’Accio, 64100 Teramo, ItalyIstituto Zooprofilattico Sperimentale dell’Abruzzo e del Molise (IZSAM), Campo Boario, 64100 Teramo, ItalyIstituto Zooprofilattico Sperimentale dell’Abruzzo e del Molise (IZSAM), Campo Boario, 64100 Teramo, ItalyFaculty of Veterinary Medicine, Veterinary University Hospital, University of Teramo, Località Piano d’Accio, 64100 Teramo, ItalyFeline morbillivirus (FeMV) is a newly discovered paramyxovirus infecting domestic cats and its role in the pathogenesis of feline chronic kidney disease (CKD) has been suggested, however not confirmed. The primary aim of the study was to evaluate the renal damage associated with FeMV infection in cats. In this retrospective study, clinical and clinicopathological data were compared among 14 FeMV naturally infected, 21 CKD and 22 healthy cats. FeMV positive cats had serum chemistry analytes and main urine chemistry results similar to the healthy subjects. FeMV positive cats had significantly decreased urine specific gravity (median 1054, range 1022–1065) and urine creatinine (median 227.23 mg/dL, range 83.02–489.75) when compared with healthy cats (median 1067, range 1040–1080, <i>p</i> < 0.001; median 406.50 mg/dL, range 195.32–575.58; <i>p</i> < 0.001, respectively). Urine protein:creatinine ratio (UPC) results of FeMV and CKD were not different (median 0.20, range 0.08–1.03; median 0.23, range 0.10–0.80, respectively), however UPC results were significantly increased in both groups, if compared with healthy cats (median 0.1, range 0.04–0.250, <i>p</i> < 0.01). Based on clinical data, serum creatinine concentration, urine specific gravity and UPC results, CKD was suspected by clinicians in 3/14 FeMV cats. Urine protein sodium-dodecyl-sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) in 10/13 (77%) FeMV cats indicated a tubular pattern, with a decrease of uromodulin and an increase in the number and intensity of low molecular weight proteins. FeMV infection can be associated with different grades of renal dysfunction ranging from mild tubular proteinuria with less concentrated urine to azotemia in cats younger than those typically affected by CKD.https://www.mdpi.com/2076-2615/10/5/828feline morbillivirusurine protein electrophoresisurine chemistrychronic kidney disease |
| spellingShingle | Paolo Emidio Crisi Francesco Dondi Eliana De Luca Morena Di Tommaso Kateryna Vasylyeva Enea Ferlizza Giovanni Savini Alessia Luciani Daniela Malatesta Alessio Lorusso Andrea Boari Early Renal Involvement in Cats with Natural Feline Morbillivirus Infection Animals feline morbillivirus urine protein electrophoresis urine chemistry chronic kidney disease |
| title | Early Renal Involvement in Cats with Natural Feline Morbillivirus Infection |
| title_full | Early Renal Involvement in Cats with Natural Feline Morbillivirus Infection |
| title_fullStr | Early Renal Involvement in Cats with Natural Feline Morbillivirus Infection |
| title_full_unstemmed | Early Renal Involvement in Cats with Natural Feline Morbillivirus Infection |
| title_short | Early Renal Involvement in Cats with Natural Feline Morbillivirus Infection |
| title_sort | early renal involvement in cats with natural feline morbillivirus infection |
| topic | feline morbillivirus urine protein electrophoresis urine chemistry chronic kidney disease |
| url | https://www.mdpi.com/2076-2615/10/5/828 |
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