Fatty acids composition of inner mitochondrial membrane of rat cardiomyocytes and hepatocytes during hypoxia-hypercapnia
We studied the influence of hypoxic-hypercapnic environment under the effect of hypothermia (artificial hibernation) on fatty acids spectrum of inner mitochondrial membrane (IMM) lipids of rat cardiomyocytes and hepatocytes. Specific for cellular organelles redistribution of IMM fatty acids was dete...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry
2016-06-01
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| Series: | The Ukrainian Biochemical Journal |
| Online Access: | http://ukrbiochemjournal.org/wp-content/uploads/2016/06/Khyzhnyak_3_16.pdf |
| _version_ | 1797641752643895296 |
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| author | S. V. Khyzhnyak S. V. Midyk S. V. Sysoliatin V. М. Voitsitsky |
| author_facet | S. V. Khyzhnyak S. V. Midyk S. V. Sysoliatin V. М. Voitsitsky |
| author_sort | S. V. Khyzhnyak |
| collection | DOAJ |
| description | We studied the influence of hypoxic-hypercapnic environment under the effect of hypothermia (artificial hibernation) on fatty acids spectrum of inner mitochondrial membrane (IMM) lipids of rat cardiomyocytes and hepatocytes. Specific for cellular organelles redistribution of IMM fatty acids was determined. It led to the reduction of total amount of saturated fatty acids (SFAs) and increase of unsaturated fatty acids (UFAs) in cardiomyocytes and to the increase of SFAs and decrease of UFAs in hepatocytes. The decrease in the content of oleic acid and increased content of arachidonic and docosahexaenoic acids in IMM were shown. This may be due to their role in the regulatory systems during hibernation, as well as following exit therefrom. It is assumed that artificial hibernation state is characterized by the stress reaction leading to optimal readjustment of fatty acids composition of membrane lipids, which supports functional activity of mitochondria in hepatocytes and cardiomyocytes. |
| first_indexed | 2024-03-11T13:50:10Z |
| format | Article |
| id | doaj.art-63b997c483c74dd782208dc4b21b7bfd |
| institution | Directory Open Access Journal |
| issn | 2409-4943 2413-5003 |
| language | English |
| last_indexed | 2024-03-11T13:50:10Z |
| publishDate | 2016-06-01 |
| publisher | National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry |
| record_format | Article |
| series | The Ukrainian Biochemical Journal |
| spelling | doaj.art-63b997c483c74dd782208dc4b21b7bfd2023-11-02T09:08:08ZengNational Academy of Sciences of Ukraine, Palladin Institute of BiochemistryThe Ukrainian Biochemical Journal2409-49432413-50032016-06-01883929810.15407/ubj88.03.092Fatty acids composition of inner mitochondrial membrane of rat cardiomyocytes and hepatocytes during hypoxia-hypercapniaS. V. Khyzhnyak0S. V. Midyk1S. V. Sysoliatin2V. М. Voitsitsky3National University of Life and Environmental Sciences of Ukraine, KyivNational University of Life and Environmental Sciences of Ukraine, KyivNational University of Life and Environmental Sciences of Ukraine, KyivNational University of Life and Environmental Sciences of Ukraine, KyivWe studied the influence of hypoxic-hypercapnic environment under the effect of hypothermia (artificial hibernation) on fatty acids spectrum of inner mitochondrial membrane (IMM) lipids of rat cardiomyocytes and hepatocytes. Specific for cellular organelles redistribution of IMM fatty acids was determined. It led to the reduction of total amount of saturated fatty acids (SFAs) and increase of unsaturated fatty acids (UFAs) in cardiomyocytes and to the increase of SFAs and decrease of UFAs in hepatocytes. The decrease in the content of oleic acid and increased content of arachidonic and docosahexaenoic acids in IMM were shown. This may be due to their role in the regulatory systems during hibernation, as well as following exit therefrom. It is assumed that artificial hibernation state is characterized by the stress reaction leading to optimal readjustment of fatty acids composition of membrane lipids, which supports functional activity of mitochondria in hepatocytes and cardiomyocytes.http://ukrbiochemjournal.org/wp-content/uploads/2016/06/Khyzhnyak_3_16.pdf |
| spellingShingle | S. V. Khyzhnyak S. V. Midyk S. V. Sysoliatin V. М. Voitsitsky Fatty acids composition of inner mitochondrial membrane of rat cardiomyocytes and hepatocytes during hypoxia-hypercapnia The Ukrainian Biochemical Journal |
| title | Fatty acids composition of inner mitochondrial membrane of rat cardiomyocytes and hepatocytes during hypoxia-hypercapnia |
| title_full | Fatty acids composition of inner mitochondrial membrane of rat cardiomyocytes and hepatocytes during hypoxia-hypercapnia |
| title_fullStr | Fatty acids composition of inner mitochondrial membrane of rat cardiomyocytes and hepatocytes during hypoxia-hypercapnia |
| title_full_unstemmed | Fatty acids composition of inner mitochondrial membrane of rat cardiomyocytes and hepatocytes during hypoxia-hypercapnia |
| title_short | Fatty acids composition of inner mitochondrial membrane of rat cardiomyocytes and hepatocytes during hypoxia-hypercapnia |
| title_sort | fatty acids composition of inner mitochondrial membrane of rat cardiomyocytes and hepatocytes during hypoxia hypercapnia |
| url | http://ukrbiochemjournal.org/wp-content/uploads/2016/06/Khyzhnyak_3_16.pdf |
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