Associations between hypertension with reproductive and menopausal factors: An integrated women's health programme (IWHP) study.
<h4>Background</h4>Women are less likely to have classic cardiovascular risk factors than men, and events during their reproductive and menopausal years may increase hypertension risk. The aim of this study is to examine woman-specific factors, including menstrual, reproductive and pregn...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2024-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0299840&type=printable |
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| author | Laureen Yi-Ting Wang Win P P Thu Yiong Huak Chan Susan Logan Michael S Kramer Jane A Cauley Eu-Leong Yong |
| author_facet | Laureen Yi-Ting Wang Win P P Thu Yiong Huak Chan Susan Logan Michael S Kramer Jane A Cauley Eu-Leong Yong |
| author_sort | Laureen Yi-Ting Wang |
| collection | DOAJ |
| description | <h4>Background</h4>Women are less likely to have classic cardiovascular risk factors than men, and events during their reproductive and menopausal years may increase hypertension risk. The aim of this study is to examine woman-specific factors, including menstrual, reproductive and pregnancy complications, in relation to the prevalence of hypertension in mid-life Asian women.<h4>Methods</h4>This is a cross-sectional study of 1146 healthy women aged 45-69 years, from a multi-ethnic Asian cohort. The women completed an extensive questionnaire that included their sociodemographic details, medical history, lifestyle and physical activity, and reproductive and menopausal history. They also underwent objectively measured physical performance tests and a dual X-ray absorptiometry scan. Hypertension was defined as a systolic BP ≥140 and/or diastolic BP ≥90mm Hg, past diagnosis by a physician, or use of antihypertensive medications. Multivariable logistic regression was used to assess the independent risk factors for hypertension.<h4>Results</h4>The average age of the 1146 women analysed was 56.3 (SD 6.2) years, and 55.2 percent of them were hypertensive. The prevalence of gestational diabetes and gestational hypertension was 12.6% and 9.4%, respectively. Besides age, abnormal menstrual cycle length at 25 years of age (OR:2.35, CI:1.34-4.13), preeclampsia (OR:2.46, CI:1.06-5.74), increased visceral adiposity (OR:4.21, CI:2.28-7.79) and reduced physical performance (OR:2.83, CI:1.46-5.47) were independently associated with hypertension in Asian women.<h4>Conclusions</h4>Our findings highlight the necessity of including features of menstrual and reproductive history as possible indicators of hypertension risk in cardiovascular disease risk assessment and prevention among Asian women. Reducing visceral adiposity and exercise to improve physical performance may help women avoid developing hypertension. |
| first_indexed | 2024-04-24T16:50:38Z |
| format | Article |
| id | doaj.art-63bb4c88a6e54133a7a40e3545221c58 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-24T16:50:38Z |
| publishDate | 2024-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-63bb4c88a6e54133a7a40e3545221c582024-03-29T05:32:51ZengPublic Library of Science (PLoS)PLoS ONE1932-62032024-01-01193e029984010.1371/journal.pone.0299840Associations between hypertension with reproductive and menopausal factors: An integrated women's health programme (IWHP) study.Laureen Yi-Ting WangWin P P ThuYiong Huak ChanSusan LoganMichael S KramerJane A CauleyEu-Leong Yong<h4>Background</h4>Women are less likely to have classic cardiovascular risk factors than men, and events during their reproductive and menopausal years may increase hypertension risk. The aim of this study is to examine woman-specific factors, including menstrual, reproductive and pregnancy complications, in relation to the prevalence of hypertension in mid-life Asian women.<h4>Methods</h4>This is a cross-sectional study of 1146 healthy women aged 45-69 years, from a multi-ethnic Asian cohort. The women completed an extensive questionnaire that included their sociodemographic details, medical history, lifestyle and physical activity, and reproductive and menopausal history. They also underwent objectively measured physical performance tests and a dual X-ray absorptiometry scan. Hypertension was defined as a systolic BP ≥140 and/or diastolic BP ≥90mm Hg, past diagnosis by a physician, or use of antihypertensive medications. Multivariable logistic regression was used to assess the independent risk factors for hypertension.<h4>Results</h4>The average age of the 1146 women analysed was 56.3 (SD 6.2) years, and 55.2 percent of them were hypertensive. The prevalence of gestational diabetes and gestational hypertension was 12.6% and 9.4%, respectively. Besides age, abnormal menstrual cycle length at 25 years of age (OR:2.35, CI:1.34-4.13), preeclampsia (OR:2.46, CI:1.06-5.74), increased visceral adiposity (OR:4.21, CI:2.28-7.79) and reduced physical performance (OR:2.83, CI:1.46-5.47) were independently associated with hypertension in Asian women.<h4>Conclusions</h4>Our findings highlight the necessity of including features of menstrual and reproductive history as possible indicators of hypertension risk in cardiovascular disease risk assessment and prevention among Asian women. Reducing visceral adiposity and exercise to improve physical performance may help women avoid developing hypertension.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0299840&type=printable |
| spellingShingle | Laureen Yi-Ting Wang Win P P Thu Yiong Huak Chan Susan Logan Michael S Kramer Jane A Cauley Eu-Leong Yong Associations between hypertension with reproductive and menopausal factors: An integrated women's health programme (IWHP) study. PLoS ONE |
| title | Associations between hypertension with reproductive and menopausal factors: An integrated women's health programme (IWHP) study. |
| title_full | Associations between hypertension with reproductive and menopausal factors: An integrated women's health programme (IWHP) study. |
| title_fullStr | Associations between hypertension with reproductive and menopausal factors: An integrated women's health programme (IWHP) study. |
| title_full_unstemmed | Associations between hypertension with reproductive and menopausal factors: An integrated women's health programme (IWHP) study. |
| title_short | Associations between hypertension with reproductive and menopausal factors: An integrated women's health programme (IWHP) study. |
| title_sort | associations between hypertension with reproductive and menopausal factors an integrated women s health programme iwhp study |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0299840&type=printable |
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