Adiponectin and Sarcopenia: A Systematic Review With Meta-Analysis
BackgroundSarcopenia is a progressive loss of skeletal muscle mass whose pathophysiology has been proposed to possibly involve mechanisms of altered inflammatory status and endocrine function. Adiponectin has been shown to modulate inflammatory status and muscle metabolism. However, the possible ass...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-04-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2021.576619/full |
| _version_ | 1828978735431286784 |
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| author | Klara Komici Antonio Dello Iacono Antonio De Luca Fabio Perrotta Leonardo Bencivenga Leonardo Bencivenga Giuseppe Rengo Giuseppe Rengo Aldo Rocca Germano Guerra |
| author_facet | Klara Komici Antonio Dello Iacono Antonio De Luca Fabio Perrotta Leonardo Bencivenga Leonardo Bencivenga Giuseppe Rengo Giuseppe Rengo Aldo Rocca Germano Guerra |
| author_sort | Klara Komici |
| collection | DOAJ |
| description | BackgroundSarcopenia is a progressive loss of skeletal muscle mass whose pathophysiology has been proposed to possibly involve mechanisms of altered inflammatory status and endocrine function. Adiponectin has been shown to modulate inflammatory status and muscle metabolism. However, the possible association between adiponectin levels and sarcopenia is poorly understood. In order to fill this gap, in the present manuscript we aimed to summarize the current evidence with a systematic review and a meta-analysis of studies reporting serum adiponectin levels in patients with sarcopenia compared to non-sarcopenic controls.MethodsAn electronic search through Medline/PubMed, Cochrane Library, and Science Direct was performed till March 1, 2020. From the included papers, meta-analysis of cross-sectional studies comparing serum levels of adiponectin between patients with sarcopenia and controls was performed.ResultsOut of 1,370 initial studies, seven studies were meta-analyzed. Sarcopenic participants had significantly higher levels of adiponectin Hedges’ g with 95% confidence interval (CI): 1.20 (0.19–2.22), p = 0.02 than controls. Subgroup analysis, performed in Asian population and focused on identification of the condition based on AWGS criteria, reported higher adiponectin levels in sarcopenic population (2.1 (0.17–4.03), p = 0.03 and I2 = 98.98%. Meta-regression analysis revealed female gender to significantly influence the results as demonstrated by beta = 0.14 (95% CI (0.010–0.280), p = 0.040).ConclusionsOur meta-analysis found evidence that sarcopenia is associated with higher adiponectin levels. However, caution is warranted on the interpretation of these findings, and future longitudinal research is required to disentangle and better understand the topic. |
| first_indexed | 2024-12-14T15:22:57Z |
| format | Article |
| id | doaj.art-63bcaf66ac2b42629af199337add549c |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-14T15:22:57Z |
| publishDate | 2021-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-63bcaf66ac2b42629af199337add549c2022-12-21T22:56:05ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922021-04-011210.3389/fendo.2021.576619576619Adiponectin and Sarcopenia: A Systematic Review With Meta-AnalysisKlara Komici0Antonio Dello Iacono1Antonio De Luca2Fabio Perrotta3Leonardo Bencivenga4Leonardo Bencivenga5Giuseppe Rengo6Giuseppe Rengo7Aldo Rocca8Germano Guerra9Department of Medicine and Health Sciences “Vincenzo Tiberio”, University of Molise, Campobasso, ItalySchool of Health and Life Sciences, University of the West of Scotland, Hamilton, United KingdomSection of Human Anatomy, Department of Mental and Physical Health and Preventive Medicine, University of Campania “Luigi Vanvitelli”, Naples, ItalyDepartment of Medicine and Health Sciences “Vincenzo Tiberio”, University of Molise, Campobasso, ItalyDepartment of Translational Medical Sciences, University of Naples “Federico II”, Naples, ItalyDepartment of Advanced Biomedical Sciences, University of Naples “Federico II”, Naples, ItalyDepartment of Translational Medical Sciences, University of Naples “Federico II”, Naples, ItalyIstituti Clinici Scientifici Maugeri SpA Società Benefit (ICS Maugeri SpA SB), Telese Terme, ItalyDepartment of Medicine and Health Sciences “Vincenzo Tiberio”, University of Molise, Campobasso, ItalyDepartment of Medicine and Health Sciences “Vincenzo Tiberio”, University of Molise, Campobasso, ItalyBackgroundSarcopenia is a progressive loss of skeletal muscle mass whose pathophysiology has been proposed to possibly involve mechanisms of altered inflammatory status and endocrine function. Adiponectin has been shown to modulate inflammatory status and muscle metabolism. However, the possible association between adiponectin levels and sarcopenia is poorly understood. In order to fill this gap, in the present manuscript we aimed to summarize the current evidence with a systematic review and a meta-analysis of studies reporting serum adiponectin levels in patients with sarcopenia compared to non-sarcopenic controls.MethodsAn electronic search through Medline/PubMed, Cochrane Library, and Science Direct was performed till March 1, 2020. From the included papers, meta-analysis of cross-sectional studies comparing serum levels of adiponectin between patients with sarcopenia and controls was performed.ResultsOut of 1,370 initial studies, seven studies were meta-analyzed. Sarcopenic participants had significantly higher levels of adiponectin Hedges’ g with 95% confidence interval (CI): 1.20 (0.19–2.22), p = 0.02 than controls. Subgroup analysis, performed in Asian population and focused on identification of the condition based on AWGS criteria, reported higher adiponectin levels in sarcopenic population (2.1 (0.17–4.03), p = 0.03 and I2 = 98.98%. Meta-regression analysis revealed female gender to significantly influence the results as demonstrated by beta = 0.14 (95% CI (0.010–0.280), p = 0.040).ConclusionsOur meta-analysis found evidence that sarcopenia is associated with higher adiponectin levels. However, caution is warranted on the interpretation of these findings, and future longitudinal research is required to disentangle and better understand the topic.https://www.frontiersin.org/articles/10.3389/fendo.2021.576619/fulladiponectinsarcopeniaagingelderlymuscle mass |
| spellingShingle | Klara Komici Antonio Dello Iacono Antonio De Luca Fabio Perrotta Leonardo Bencivenga Leonardo Bencivenga Giuseppe Rengo Giuseppe Rengo Aldo Rocca Germano Guerra Adiponectin and Sarcopenia: A Systematic Review With Meta-Analysis Frontiers in Endocrinology adiponectin sarcopenia aging elderly muscle mass |
| title | Adiponectin and Sarcopenia: A Systematic Review With Meta-Analysis |
| title_full | Adiponectin and Sarcopenia: A Systematic Review With Meta-Analysis |
| title_fullStr | Adiponectin and Sarcopenia: A Systematic Review With Meta-Analysis |
| title_full_unstemmed | Adiponectin and Sarcopenia: A Systematic Review With Meta-Analysis |
| title_short | Adiponectin and Sarcopenia: A Systematic Review With Meta-Analysis |
| title_sort | adiponectin and sarcopenia a systematic review with meta analysis |
| topic | adiponectin sarcopenia aging elderly muscle mass |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2021.576619/full |
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