Metabolic cost of unloading pedalling in different groups of patients with pulmonary hypertension and volunteers
Abstract Recently, the parameter internal work (IW) has been introduced as change in oxygen uptake (VO2) between resting and unloading workload in cardiopulmonary exercise testing (CPET). The proportional IW (PIW) was defined as IW divided by VO2 at peak exercise. A second option is to calculate the...
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| Format: | Article |
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Nature Portfolio
2024-03-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-55980-z |
| _version_ | 1827327445048492032 |
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| author | Till Ittermann Sabine Kaczmarek Anne Obst Raik Könemann Martin Bahls Marcus Dörr Beate Stubbe Alexander Heine Dirk Habedank Ralf Ewert |
| author_facet | Till Ittermann Sabine Kaczmarek Anne Obst Raik Könemann Martin Bahls Marcus Dörr Beate Stubbe Alexander Heine Dirk Habedank Ralf Ewert |
| author_sort | Till Ittermann |
| collection | DOAJ |
| description | Abstract Recently, the parameter internal work (IW) has been introduced as change in oxygen uptake (VO2) between resting and unloading workload in cardiopulmonary exercise testing (CPET). The proportional IW (PIW) was defined as IW divided by VO2 at peak exercise. A second option is to calculate the PIW based on the workload [PIW (Watt)] by considering the aerobic efficiency. The aim of our study was to investigate whether IW and PIW differ between patients with and without pulmonary hypertension and healthy controls. Our study population consisted of 580 patients and 354 healthy controls derived from the Study of Health in Pomerania. The PIW was slightly lower in patients (14.2%) than in healthy controls (14.9%; p = 0.030), but the PIW (Watt) was higher in patients (18.0%) than in the healthy controls (15.9%; p = 0.001). Such a difference was also observed, when considering only the submaximal workload up to the VAT (19.8% in patients and 15.1% in healthy controls; p < 0.001). Since the PIW (Watt) values were higher in patients with pulmonary hypertension, this marker may serve as a useful CPET parameter in clinical practice. In contrast to most of the currently used CPET parameters, the PIW does not require a maximal workload for the patient. Further studies are needed to validate the prognostic significance of the PIW. |
| first_indexed | 2024-03-07T15:01:19Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-07T15:01:19Z |
| publishDate | 2024-03-01 |
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| series | Scientific Reports |
| spelling | doaj.art-63bd9cc212ba42329744dd7f7490a93d2024-03-05T19:08:30ZengNature PortfolioScientific Reports2045-23222024-03-011411910.1038/s41598-024-55980-zMetabolic cost of unloading pedalling in different groups of patients with pulmonary hypertension and volunteersTill Ittermann0Sabine Kaczmarek1Anne Obst2Raik Könemann3Martin Bahls4Marcus Dörr5Beate Stubbe6Alexander Heine7Dirk Habedank8Ralf Ewert9Institute for Community Medicine - SHIP Clinical-Epidemiological Research, University Medicine GreifswaldGerman Centre for Cardiovascular Research (DZHK), Partner Site GreifswaldDepartment of Internal Medicine B, University Medicine GreifswaldDepartment of Internal Medicine B, University Medicine GreifswaldGerman Centre for Cardiovascular Research (DZHK), Partner Site GreifswaldGerman Centre for Cardiovascular Research (DZHK), Partner Site GreifswaldDepartment of Internal Medicine B, University Medicine GreifswaldDepartment of Internal Medicine B, University Medicine GreifswaldDepartment of Internal Medicine, DRK Krankenhaus BerlinDepartment of Internal Medicine B, University Medicine GreifswaldAbstract Recently, the parameter internal work (IW) has been introduced as change in oxygen uptake (VO2) between resting and unloading workload in cardiopulmonary exercise testing (CPET). The proportional IW (PIW) was defined as IW divided by VO2 at peak exercise. A second option is to calculate the PIW based on the workload [PIW (Watt)] by considering the aerobic efficiency. The aim of our study was to investigate whether IW and PIW differ between patients with and without pulmonary hypertension and healthy controls. Our study population consisted of 580 patients and 354 healthy controls derived from the Study of Health in Pomerania. The PIW was slightly lower in patients (14.2%) than in healthy controls (14.9%; p = 0.030), but the PIW (Watt) was higher in patients (18.0%) than in the healthy controls (15.9%; p = 0.001). Such a difference was also observed, when considering only the submaximal workload up to the VAT (19.8% in patients and 15.1% in healthy controls; p < 0.001). Since the PIW (Watt) values were higher in patients with pulmonary hypertension, this marker may serve as a useful CPET parameter in clinical practice. In contrast to most of the currently used CPET parameters, the PIW does not require a maximal workload for the patient. Further studies are needed to validate the prognostic significance of the PIW.https://doi.org/10.1038/s41598-024-55980-z |
| spellingShingle | Till Ittermann Sabine Kaczmarek Anne Obst Raik Könemann Martin Bahls Marcus Dörr Beate Stubbe Alexander Heine Dirk Habedank Ralf Ewert Metabolic cost of unloading pedalling in different groups of patients with pulmonary hypertension and volunteers Scientific Reports |
| title | Metabolic cost of unloading pedalling in different groups of patients with pulmonary hypertension and volunteers |
| title_full | Metabolic cost of unloading pedalling in different groups of patients with pulmonary hypertension and volunteers |
| title_fullStr | Metabolic cost of unloading pedalling in different groups of patients with pulmonary hypertension and volunteers |
| title_full_unstemmed | Metabolic cost of unloading pedalling in different groups of patients with pulmonary hypertension and volunteers |
| title_short | Metabolic cost of unloading pedalling in different groups of patients with pulmonary hypertension and volunteers |
| title_sort | metabolic cost of unloading pedalling in different groups of patients with pulmonary hypertension and volunteers |
| url | https://doi.org/10.1038/s41598-024-55980-z |
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