Ninjin'yoeito Targets Distinct Ca2+ Channels to Activate Ghrelin-Responsive vs. Unresponsive NPY Neurons in the Arcuate Nucleus

Ninjin'yoeito Targets Distinct Ca2+ Channels to Activate Ghrelin-Responsive vs. Unresponsive NPY Neurons in the Arcuate Nucleus

Appetite loss or anorexia substantially deteriorates quality of life in various diseases, and stand upstream of frailty. Neuropeptide Y (NPY) in the hypothalamic arcuate nucleus (ARC) and ghrelin released from stomach are potent inducers of appetite. We previously reported that Ninjin'yoeito, a...

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Bibliographic Details
Main Authors: Chayon Goswami, Katsuya Dezaki, Lei Wang, Akio Inui, Yutaka Seino, Toshihiko Yada
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Nutrition
Subjects:
Ninjin-yoeito
anorexia
arcuate nucleus
neuropeptide Y
ghrelin
N-type Ca2+ channel
Online Access:https://www.frontiersin.org/article/10.3389/fnut.2020.00104/full

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