BMI and plasma lipid levels with risk of proliferative diabetic retinopathy: a univariable and multivariable Mendelian randomization study
BackgroundThe study aimed to determine whether a causal effect exists between body mass index (BMI) or plasma lipid levels and proliferative diabetic retinopathy (PDR) risk in humans.MethodsWe utilized univariable (UVMR) and multivariable two-sample Mendelian randomization (MVMR) analyses to confirm...
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2023.1099807/full |
| _version_ | 1797687188426588160 |
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| author | Yiyang Shu Qi Zhou Yuting Shao Hui Lin Shen Qu Wenting Han Xiao Lv Yanlong Bi Yanlong Bi |
| author_facet | Yiyang Shu Qi Zhou Yuting Shao Hui Lin Shen Qu Wenting Han Xiao Lv Yanlong Bi Yanlong Bi |
| author_sort | Yiyang Shu |
| collection | DOAJ |
| description | BackgroundThe study aimed to determine whether a causal effect exists between body mass index (BMI) or plasma lipid levels and proliferative diabetic retinopathy (PDR) risk in humans.MethodsWe utilized univariable (UVMR) and multivariable two-sample Mendelian randomization (MVMR) analyses to confirm the effects of BMI and plasma lipid levels on the risk of PDR. Genetic variants associated with BMI and three plasma lipids were obtained from GWAS summary datasets generated by many different consortia and were deposited in the MR-Base database. The GWAS summary data for PDR from the FinnGen biobank included 2,12,889 participants of European ancestry (8,681 cases and 2,04,208 controls). Inverse variance weighted (IVW) was applied as the main MR analysis. Sensitivity analysis was used to evaluate the robustness of our findings.ResultsIn the UVMR analysis, the causal associations of genetically predicted BMI with PDR presented a positive association (OR = 1.120, 95% CI = 1.076–1.167, P < 0.001), and the lower HDL-C level was associated with a higher risk of PDR (OR = 0.898, 95% CI = 0.811–0.995, P = 0.040). No evidence of an association between LDL-C or TG levels (P > 0.05) and PDR risk was found. In the MVMR analysis controlling for the HDL-C level, there was strong evidence for a direct causal effect of BMI on the risk of PDR (OR = 1.106, 95%CI = 1.049, 1.166, P < 0.001, IVW). After adjusting for BMI, there was no evidence for a direct causal effect of the HDL-C level on the risk of PDR (OR = 0.911, 95% CI = 0.823, 1.008, P = 0.072). Sensitivity analyses confirmed that the results were reliable and stable.ConclusionRobust evidence was demonstrated for an independent, causal effect of BMI in increasing the risk of PDR. Further studies are required to understand the potential biological mechanisms underlying this causal relationship. |
| first_indexed | 2024-03-12T01:15:40Z |
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| id | doaj.art-63c0d12a006a4aeeb9bbbed072ab4d46 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-03-12T01:15:40Z |
| publishDate | 2023-09-01 |
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| series | Frontiers in Nutrition |
| spelling | doaj.art-63c0d12a006a4aeeb9bbbed072ab4d462023-09-13T12:38:11ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-09-011010.3389/fnut.2023.10998071099807BMI and plasma lipid levels with risk of proliferative diabetic retinopathy: a univariable and multivariable Mendelian randomization studyYiyang Shu0Qi Zhou1Yuting Shao2Hui Lin3Shen Qu4Wenting Han5Xiao Lv6Yanlong Bi7Yanlong Bi8Department of Ophthalmology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, ChinaExam Center, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Ophthalmology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Ophthalmology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Ophthalmology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Ophthalmology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Ophthalmology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Ophthalmology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, ChinaSchool of Medicine, Tongji Eye Institute, Tongji University, Shanghai, ChinaBackgroundThe study aimed to determine whether a causal effect exists between body mass index (BMI) or plasma lipid levels and proliferative diabetic retinopathy (PDR) risk in humans.MethodsWe utilized univariable (UVMR) and multivariable two-sample Mendelian randomization (MVMR) analyses to confirm the effects of BMI and plasma lipid levels on the risk of PDR. Genetic variants associated with BMI and three plasma lipids were obtained from GWAS summary datasets generated by many different consortia and were deposited in the MR-Base database. The GWAS summary data for PDR from the FinnGen biobank included 2,12,889 participants of European ancestry (8,681 cases and 2,04,208 controls). Inverse variance weighted (IVW) was applied as the main MR analysis. Sensitivity analysis was used to evaluate the robustness of our findings.ResultsIn the UVMR analysis, the causal associations of genetically predicted BMI with PDR presented a positive association (OR = 1.120, 95% CI = 1.076–1.167, P < 0.001), and the lower HDL-C level was associated with a higher risk of PDR (OR = 0.898, 95% CI = 0.811–0.995, P = 0.040). No evidence of an association between LDL-C or TG levels (P > 0.05) and PDR risk was found. In the MVMR analysis controlling for the HDL-C level, there was strong evidence for a direct causal effect of BMI on the risk of PDR (OR = 1.106, 95%CI = 1.049, 1.166, P < 0.001, IVW). After adjusting for BMI, there was no evidence for a direct causal effect of the HDL-C level on the risk of PDR (OR = 0.911, 95% CI = 0.823, 1.008, P = 0.072). Sensitivity analyses confirmed that the results were reliable and stable.ConclusionRobust evidence was demonstrated for an independent, causal effect of BMI in increasing the risk of PDR. Further studies are required to understand the potential biological mechanisms underlying this causal relationship.https://www.frontiersin.org/articles/10.3389/fnut.2023.1099807/fullproliferative diabetic retinopathy (PDR)body mass index (BMI)dyslipidemiaMendelian randomizationcausal effect |
| spellingShingle | Yiyang Shu Qi Zhou Yuting Shao Hui Lin Shen Qu Wenting Han Xiao Lv Yanlong Bi Yanlong Bi BMI and plasma lipid levels with risk of proliferative diabetic retinopathy: a univariable and multivariable Mendelian randomization study Frontiers in Nutrition proliferative diabetic retinopathy (PDR) body mass index (BMI) dyslipidemia Mendelian randomization causal effect |
| title | BMI and plasma lipid levels with risk of proliferative diabetic retinopathy: a univariable and multivariable Mendelian randomization study |
| title_full | BMI and plasma lipid levels with risk of proliferative diabetic retinopathy: a univariable and multivariable Mendelian randomization study |
| title_fullStr | BMI and plasma lipid levels with risk of proliferative diabetic retinopathy: a univariable and multivariable Mendelian randomization study |
| title_full_unstemmed | BMI and plasma lipid levels with risk of proliferative diabetic retinopathy: a univariable and multivariable Mendelian randomization study |
| title_short | BMI and plasma lipid levels with risk of proliferative diabetic retinopathy: a univariable and multivariable Mendelian randomization study |
| title_sort | bmi and plasma lipid levels with risk of proliferative diabetic retinopathy a univariable and multivariable mendelian randomization study |
| topic | proliferative diabetic retinopathy (PDR) body mass index (BMI) dyslipidemia Mendelian randomization causal effect |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2023.1099807/full |
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