Advances in SIV/SHIV Non-Human Primate Models of NeuroAIDS
Non-human primates (NHPs) are the most relevant model of Acquired Immunodeficiency Syndrome (AIDS) and neuroAIDS, being of great importance in explaining the pathogenesis of HIV-induced nervous system damage. Simian Immunodeficiency Virus (SIV)/ Simian-Human Immunodeficiency Virus (SHIV)-infected mo...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Pathogens |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-0817/10/8/1018 |
| _version_ | 1797522496160792576 |
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| author | Sonia Moretti Sara Virtuoso Leonardo Sernicola Stefania Farcomeni Maria Teresa Maggiorella Alessandra Borsetti |
| author_facet | Sonia Moretti Sara Virtuoso Leonardo Sernicola Stefania Farcomeni Maria Teresa Maggiorella Alessandra Borsetti |
| author_sort | Sonia Moretti |
| collection | DOAJ |
| description | Non-human primates (NHPs) are the most relevant model of Acquired Immunodeficiency Syndrome (AIDS) and neuroAIDS, being of great importance in explaining the pathogenesis of HIV-induced nervous system damage. Simian Immunodeficiency Virus (SIV)/ Simian-Human Immunodeficiency Virus (SHIV)-infected monkeys have provided evidence of complex interactions between the virus and host that include host immune response, viral genetic diversity, and genetic susceptibility, which may explain virus-associated central nervous system (CNS) pathology and HIV-associated neurocognitive disorders (HAND). In this article, we review the recent progress contributions obtained using monkey models of HIV infection of the CNS, neuropathogenesis and SIV encephalitis (SIVE), with an emphasis on pharmacologic therapies and dependable markers that predict development of CNS AIDS. |
| first_indexed | 2024-03-10T08:29:16Z |
| format | Article |
| id | doaj.art-63c12f8b48f9464db8c9c8cb1a3c37d3 |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-10T08:29:16Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-63c12f8b48f9464db8c9c8cb1a3c37d32023-11-22T09:09:33ZengMDPI AGPathogens2076-08172021-08-01108101810.3390/pathogens10081018Advances in SIV/SHIV Non-Human Primate Models of NeuroAIDSSonia Moretti0Sara Virtuoso1Leonardo Sernicola2Stefania Farcomeni3Maria Teresa Maggiorella4Alessandra Borsetti5National HIV/AIDS Research Center, Istituto Superiore di Sanità, 00162 Rome, ItalyNational HIV/AIDS Research Center, Istituto Superiore di Sanità, 00162 Rome, ItalyNational HIV/AIDS Research Center, Istituto Superiore di Sanità, 00162 Rome, ItalyNational HIV/AIDS Research Center, Istituto Superiore di Sanità, 00162 Rome, ItalyNational HIV/AIDS Research Center, Istituto Superiore di Sanità, 00162 Rome, ItalyNational HIV/AIDS Research Center, Istituto Superiore di Sanità, 00162 Rome, ItalyNon-human primates (NHPs) are the most relevant model of Acquired Immunodeficiency Syndrome (AIDS) and neuroAIDS, being of great importance in explaining the pathogenesis of HIV-induced nervous system damage. Simian Immunodeficiency Virus (SIV)/ Simian-Human Immunodeficiency Virus (SHIV)-infected monkeys have provided evidence of complex interactions between the virus and host that include host immune response, viral genetic diversity, and genetic susceptibility, which may explain virus-associated central nervous system (CNS) pathology and HIV-associated neurocognitive disorders (HAND). In this article, we review the recent progress contributions obtained using monkey models of HIV infection of the CNS, neuropathogenesis and SIV encephalitis (SIVE), with an emphasis on pharmacologic therapies and dependable markers that predict development of CNS AIDS.https://www.mdpi.com/2076-0817/10/8/1018neuroAIDSSimian Immunodeficiency Virusmacrophagesmacaquemarkersinflammation |
| spellingShingle | Sonia Moretti Sara Virtuoso Leonardo Sernicola Stefania Farcomeni Maria Teresa Maggiorella Alessandra Borsetti Advances in SIV/SHIV Non-Human Primate Models of NeuroAIDS Pathogens neuroAIDS Simian Immunodeficiency Virus macrophages macaque markers inflammation |
| title | Advances in SIV/SHIV Non-Human Primate Models of NeuroAIDS |
| title_full | Advances in SIV/SHIV Non-Human Primate Models of NeuroAIDS |
| title_fullStr | Advances in SIV/SHIV Non-Human Primate Models of NeuroAIDS |
| title_full_unstemmed | Advances in SIV/SHIV Non-Human Primate Models of NeuroAIDS |
| title_short | Advances in SIV/SHIV Non-Human Primate Models of NeuroAIDS |
| title_sort | advances in siv shiv non human primate models of neuroaids |
| topic | neuroAIDS Simian Immunodeficiency Virus macrophages macaque markers inflammation |
| url | https://www.mdpi.com/2076-0817/10/8/1018 |
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