Efficacy and immune-inflammatory mechanism of acupuncture-related therapy in animal models of knee osteoarthritis: a preclinical systematic review and network meta-analysis
Abstract Background Many KOA patients have not reached indications for surgery, thus we need to find effective non-surgical treatments. Acupuncture is thought to have the potential to modulate inflammation and cytokines in KOA through the immune system. However, the mechanisms have not been elucidat...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-03-01
|
| Series: | Journal of Orthopaedic Surgery and Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13018-024-04660-9 |
| _version_ | 1797266702138867712 |
|---|---|
| author | Yingjie Huang Hai Huang Qiqi Chen Yantong Luo Jieni Feng Yuexia Deng Guangyao Li Min Li Jian Sun |
| author_facet | Yingjie Huang Hai Huang Qiqi Chen Yantong Luo Jieni Feng Yuexia Deng Guangyao Li Min Li Jian Sun |
| author_sort | Yingjie Huang |
| collection | DOAJ |
| description | Abstract Background Many KOA patients have not reached indications for surgery, thus we need to find effective non-surgical treatments. Acupuncture is thought to have the potential to modulate inflammation and cytokines in KOA through the immune system. However, the mechanisms have not been elucidated, and there is no network Meta-analysis of acupuncture on KOA animals. So we evaluate the effect and mechanism of acupuncture-related therapy in KOA animals. Methods A comprehensive search was conducted in multiple databases including PubMed, Web of Science, Embase, CBM, CNKI, WanFang, and VIP Database to identify relevant animal studies focusing on acupuncture therapy for KOA. The included studies were assessed for risk of bias using SYRCLE's Risk of Bias tool. Subsequently, pair-wise meta-analysis and network meta-analysis were performed using Stata 15.0 software, evaluating outcomes such as Lequesne index scale, Mankin score, IL-1β, TNF-α, MMP3, and MMP13. Results 56 RCTs with 2394 animals were included. Meta-analysis showed that among the 6 outcomes, there were significant differences between acupuncture and model group; the overall results of network meta-analysis showed that the normal group or sham operation group performed the best, followed by the acupotomy, acupuncture, and medicine group, and the model group had the worst effect, and there were significant differences between 6 interventions. Conclusions Acupuncture-related therapy can be a possible treatment for KOA. The mechanism involves many immune-inflammatory pathways, which may be mediated by DAMPs/TLR/NF-κB/MAPK,PI3K/Akt/NF-κB pathway, or IFN-γ/JAK-STAT pathway. It needs to be further confirmed by more high-quality animal experiments or meta-analysis. Systematic review registration PROSPERO identifier: CRD42023377228. |
| first_indexed | 2024-04-25T01:04:53Z |
| format | Article |
| id | doaj.art-63c1a6a2566841c68997c7872147fa33 |
| institution | Directory Open Access Journal |
| issn | 1749-799X |
| language | English |
| last_indexed | 2024-04-25T01:04:53Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Orthopaedic Surgery and Research |
| spelling | doaj.art-63c1a6a2566841c68997c7872147fa332024-03-10T12:18:06ZengBMCJournal of Orthopaedic Surgery and Research1749-799X2024-03-0119111610.1186/s13018-024-04660-9Efficacy and immune-inflammatory mechanism of acupuncture-related therapy in animal models of knee osteoarthritis: a preclinical systematic review and network meta-analysisYingjie Huang0Hai Huang1Qiqi Chen2Yantong Luo3Jieni Feng4Yuexia Deng5Guangyao Li6Min Li7Jian Sun8Clinical Medical College of Acupuncture Moxibustion and Rehabilitation, Guangzhou University of Chinese MedicineThe Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou University of Chinese MedicineThe Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou University of Chinese MedicineThe First Clinical College of Guangzhou University of Chinese Medicine, Guangzhou University of Chinese MedicineThe Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou University of Chinese MedicineSouthern Theater General HospitalDepartment of traditional Chinese medicine; Guangdong Provincial Key Laboratory of Major Obstetric Diseases; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical UniversityClinical Medical College of Acupuncture Moxibustion and Rehabilitation, Guangzhou University of Chinese MedicineClinical Medical College of Acupuncture Moxibustion and Rehabilitation, Guangzhou University of Chinese MedicineAbstract Background Many KOA patients have not reached indications for surgery, thus we need to find effective non-surgical treatments. Acupuncture is thought to have the potential to modulate inflammation and cytokines in KOA through the immune system. However, the mechanisms have not been elucidated, and there is no network Meta-analysis of acupuncture on KOA animals. So we evaluate the effect and mechanism of acupuncture-related therapy in KOA animals. Methods A comprehensive search was conducted in multiple databases including PubMed, Web of Science, Embase, CBM, CNKI, WanFang, and VIP Database to identify relevant animal studies focusing on acupuncture therapy for KOA. The included studies were assessed for risk of bias using SYRCLE's Risk of Bias tool. Subsequently, pair-wise meta-analysis and network meta-analysis were performed using Stata 15.0 software, evaluating outcomes such as Lequesne index scale, Mankin score, IL-1β, TNF-α, MMP3, and MMP13. Results 56 RCTs with 2394 animals were included. Meta-analysis showed that among the 6 outcomes, there were significant differences between acupuncture and model group; the overall results of network meta-analysis showed that the normal group or sham operation group performed the best, followed by the acupotomy, acupuncture, and medicine group, and the model group had the worst effect, and there were significant differences between 6 interventions. Conclusions Acupuncture-related therapy can be a possible treatment for KOA. The mechanism involves many immune-inflammatory pathways, which may be mediated by DAMPs/TLR/NF-κB/MAPK,PI3K/Akt/NF-κB pathway, or IFN-γ/JAK-STAT pathway. It needs to be further confirmed by more high-quality animal experiments or meta-analysis. Systematic review registration PROSPERO identifier: CRD42023377228.https://doi.org/10.1186/s13018-024-04660-9AcupunctureAcupotomyKnee osteoarthritisAnimal modelsImmunityInflammation |
| spellingShingle | Yingjie Huang Hai Huang Qiqi Chen Yantong Luo Jieni Feng Yuexia Deng Guangyao Li Min Li Jian Sun Efficacy and immune-inflammatory mechanism of acupuncture-related therapy in animal models of knee osteoarthritis: a preclinical systematic review and network meta-analysis Journal of Orthopaedic Surgery and Research Acupuncture Acupotomy Knee osteoarthritis Animal models Immunity Inflammation |
| title | Efficacy and immune-inflammatory mechanism of acupuncture-related therapy in animal models of knee osteoarthritis: a preclinical systematic review and network meta-analysis |
| title_full | Efficacy and immune-inflammatory mechanism of acupuncture-related therapy in animal models of knee osteoarthritis: a preclinical systematic review and network meta-analysis |
| title_fullStr | Efficacy and immune-inflammatory mechanism of acupuncture-related therapy in animal models of knee osteoarthritis: a preclinical systematic review and network meta-analysis |
| title_full_unstemmed | Efficacy and immune-inflammatory mechanism of acupuncture-related therapy in animal models of knee osteoarthritis: a preclinical systematic review and network meta-analysis |
| title_short | Efficacy and immune-inflammatory mechanism of acupuncture-related therapy in animal models of knee osteoarthritis: a preclinical systematic review and network meta-analysis |
| title_sort | efficacy and immune inflammatory mechanism of acupuncture related therapy in animal models of knee osteoarthritis a preclinical systematic review and network meta analysis |
| topic | Acupuncture Acupotomy Knee osteoarthritis Animal models Immunity Inflammation |
| url | https://doi.org/10.1186/s13018-024-04660-9 |
| work_keys_str_mv | AT yingjiehuang efficacyandimmuneinflammatorymechanismofacupuncturerelatedtherapyinanimalmodelsofkneeosteoarthritisapreclinicalsystematicreviewandnetworkmetaanalysis AT haihuang efficacyandimmuneinflammatorymechanismofacupuncturerelatedtherapyinanimalmodelsofkneeosteoarthritisapreclinicalsystematicreviewandnetworkmetaanalysis AT qiqichen efficacyandimmuneinflammatorymechanismofacupuncturerelatedtherapyinanimalmodelsofkneeosteoarthritisapreclinicalsystematicreviewandnetworkmetaanalysis AT yantongluo efficacyandimmuneinflammatorymechanismofacupuncturerelatedtherapyinanimalmodelsofkneeosteoarthritisapreclinicalsystematicreviewandnetworkmetaanalysis AT jienifeng efficacyandimmuneinflammatorymechanismofacupuncturerelatedtherapyinanimalmodelsofkneeosteoarthritisapreclinicalsystematicreviewandnetworkmetaanalysis AT yuexiadeng efficacyandimmuneinflammatorymechanismofacupuncturerelatedtherapyinanimalmodelsofkneeosteoarthritisapreclinicalsystematicreviewandnetworkmetaanalysis AT guangyaoli efficacyandimmuneinflammatorymechanismofacupuncturerelatedtherapyinanimalmodelsofkneeosteoarthritisapreclinicalsystematicreviewandnetworkmetaanalysis AT minli efficacyandimmuneinflammatorymechanismofacupuncturerelatedtherapyinanimalmodelsofkneeosteoarthritisapreclinicalsystematicreviewandnetworkmetaanalysis AT jiansun efficacyandimmuneinflammatorymechanismofacupuncturerelatedtherapyinanimalmodelsofkneeosteoarthritisapreclinicalsystematicreviewandnetworkmetaanalysis |