The Radiotherapy Role in the Multidisciplinary Management of Locally Advanced Vulvar Cancer: A Multidisciplinary VulCan Team Review
Locally advanced vulvar cancer (LAVC) is a challenging disease, requiring multidisciplinary management. The aim of this review is to propose an integrated clinical approach including radiotherapy (RT) in the multidisciplinary management of LAVC to customize the treatment. A review of the literature...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/22/5747 |
| _version_ | 1797510937326911488 |
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| author | Luca Tagliaferri Valentina Lancellotta Calogero Casà Simona Maria Fragomeni Martina Ferioli Stefano Gentileschi Anna Amelia Caretto Giacomo Corrado Benedetta Gui Giuseppe Ferdinando Colloca Maria Antonietta Gambacorta Alessio Giuseppe Morganti Giorgia Garganese Gabriella Macchia |
| author_facet | Luca Tagliaferri Valentina Lancellotta Calogero Casà Simona Maria Fragomeni Martina Ferioli Stefano Gentileschi Anna Amelia Caretto Giacomo Corrado Benedetta Gui Giuseppe Ferdinando Colloca Maria Antonietta Gambacorta Alessio Giuseppe Morganti Giorgia Garganese Gabriella Macchia |
| author_sort | Luca Tagliaferri |
| collection | DOAJ |
| description | Locally advanced vulvar cancer (LAVC) is a challenging disease, requiring multidisciplinary management. The aim of this review is to propose an integrated clinical approach including radiotherapy (RT) in the multidisciplinary management of LAVC to customize the treatment. A review of the literature was conducted on PubMed, Scopus, and Cochrane library to acquire all relevant studies on RT in LAVC. Based on the available evidence, RT, with or without concurrent chemotherapy, has a relevant role as adjuvant and exclusive treatment or in the neoadjuvant setting. However, multicentric prospective trials are needed to define the best treatment options based on tumor and patient characteristics. A multidisciplinary and multidimensional assessment can also be useful to identify the most suitable approach, considering patients’ age and comorbidities, in view of a better treatment personalization. |
| first_indexed | 2024-03-10T05:38:17Z |
| format | Article |
| id | doaj.art-63c1b85b8f474c42a4d77aaad39cd2b4 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T05:38:17Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-63c1b85b8f474c42a4d77aaad39cd2b42023-11-22T22:42:43ZengMDPI AGCancers2072-66942021-11-011322574710.3390/cancers13225747The Radiotherapy Role in the Multidisciplinary Management of Locally Advanced Vulvar Cancer: A Multidisciplinary VulCan Team ReviewLuca Tagliaferri0Valentina Lancellotta1Calogero Casà2Simona Maria Fragomeni3Martina Ferioli4Stefano Gentileschi5Anna Amelia Caretto6Giacomo Corrado7Benedetta Gui8Giuseppe Ferdinando Colloca9Maria Antonietta Gambacorta10Alessio Giuseppe Morganti11Giorgia Garganese12Gabriella Macchia13Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia—Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyDipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia—Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyDipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia—Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyDipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyRadiation Oncology Center, IRCCS Azienda Ospedaliero Universitaria di Bologna, DIMES, Alma Mater Studiorum—Bologna University, 40138 Bologna, ItalyDipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyUniversità Cattolica del Sacro Cuore, 00168 Rome, ItalyDipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyDipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia—Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyDipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia—Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyDipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia—Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyRadiation Oncology Center, IRCCS Azienda Ospedaliero Universitaria di Bologna, DIMES, Alma Mater Studiorum—Bologna University, 40138 Bologna, ItalyGynecology and Breast Care Center, Mater Olbia Hospital, 07026 Olbia, ItalyUnità Operativa di Radioterapia, Ospedale Gemelli Molise, Università Cattolica del Sacro Cuore, 86100 Campobasso, ItalyLocally advanced vulvar cancer (LAVC) is a challenging disease, requiring multidisciplinary management. The aim of this review is to propose an integrated clinical approach including radiotherapy (RT) in the multidisciplinary management of LAVC to customize the treatment. A review of the literature was conducted on PubMed, Scopus, and Cochrane library to acquire all relevant studies on RT in LAVC. Based on the available evidence, RT, with or without concurrent chemotherapy, has a relevant role as adjuvant and exclusive treatment or in the neoadjuvant setting. However, multicentric prospective trials are needed to define the best treatment options based on tumor and patient characteristics. A multidisciplinary and multidimensional assessment can also be useful to identify the most suitable approach, considering patients’ age and comorbidities, in view of a better treatment personalization.https://www.mdpi.com/2072-6694/13/22/5747vulvar cancerradiotherapyreview |
| spellingShingle | Luca Tagliaferri Valentina Lancellotta Calogero Casà Simona Maria Fragomeni Martina Ferioli Stefano Gentileschi Anna Amelia Caretto Giacomo Corrado Benedetta Gui Giuseppe Ferdinando Colloca Maria Antonietta Gambacorta Alessio Giuseppe Morganti Giorgia Garganese Gabriella Macchia The Radiotherapy Role in the Multidisciplinary Management of Locally Advanced Vulvar Cancer: A Multidisciplinary VulCan Team Review Cancers vulvar cancer radiotherapy review |
| title | The Radiotherapy Role in the Multidisciplinary Management of Locally Advanced Vulvar Cancer: A Multidisciplinary VulCan Team Review |
| title_full | The Radiotherapy Role in the Multidisciplinary Management of Locally Advanced Vulvar Cancer: A Multidisciplinary VulCan Team Review |
| title_fullStr | The Radiotherapy Role in the Multidisciplinary Management of Locally Advanced Vulvar Cancer: A Multidisciplinary VulCan Team Review |
| title_full_unstemmed | The Radiotherapy Role in the Multidisciplinary Management of Locally Advanced Vulvar Cancer: A Multidisciplinary VulCan Team Review |
| title_short | The Radiotherapy Role in the Multidisciplinary Management of Locally Advanced Vulvar Cancer: A Multidisciplinary VulCan Team Review |
| title_sort | radiotherapy role in the multidisciplinary management of locally advanced vulvar cancer a multidisciplinary vulcan team review |
| topic | vulvar cancer radiotherapy review |
| url | https://www.mdpi.com/2072-6694/13/22/5747 |
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