Biomarkers involved in the pathogenesis of cerebral small-vessel disease
Cerebral small-vessel disease (CSVD) has been found to have a strong association with vascular cognitive impairment (VCI) and functional loss in elderly patients. At present, the diagnosis of CSVD mainly relies on brain neuroimaging markers, but they cannot fully reflect the overall picture of the d...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.969185/full |
| _version_ | 1817996133943738368 |
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| author | Xiaolu Liu Pei Sun Jing Yang Yuhua Fan |
| author_facet | Xiaolu Liu Pei Sun Jing Yang Yuhua Fan |
| author_sort | Xiaolu Liu |
| collection | DOAJ |
| description | Cerebral small-vessel disease (CSVD) has been found to have a strong association with vascular cognitive impairment (VCI) and functional loss in elderly patients. At present, the diagnosis of CSVD mainly relies on brain neuroimaging markers, but they cannot fully reflect the overall picture of the disease. Currently, some biomarkers were found to be related to CSVD, but the underlying mechanisms remain unclear. We aimed to systematically review and summarize studies on the progress of biomarkers related to the pathogenesis of CSVD, which is mainly the relationship between these indicators and neuroimaging markers of CSVD. Concerning the pathophysiological mechanism of CSVD, the biomarkers of CSVD have been described as several categories related to sporadic and genetic factors. Monitoring of biomarkers might contribute to the early diagnosis and progression prediction of CSVD, thus providing ideas for better diagnosis and treatment of CSVD. |
| first_indexed | 2024-04-14T02:17:42Z |
| format | Article |
| id | doaj.art-63c23608db2847d7928b88f8755e28d9 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-14T02:17:42Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-63c23608db2847d7928b88f8755e28d92022-12-22T02:18:07ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-09-011310.3389/fneur.2022.969185969185Biomarkers involved in the pathogenesis of cerebral small-vessel diseaseXiaolu LiuPei SunJing YangYuhua FanCerebral small-vessel disease (CSVD) has been found to have a strong association with vascular cognitive impairment (VCI) and functional loss in elderly patients. At present, the diagnosis of CSVD mainly relies on brain neuroimaging markers, but they cannot fully reflect the overall picture of the disease. Currently, some biomarkers were found to be related to CSVD, but the underlying mechanisms remain unclear. We aimed to systematically review and summarize studies on the progress of biomarkers related to the pathogenesis of CSVD, which is mainly the relationship between these indicators and neuroimaging markers of CSVD. Concerning the pathophysiological mechanism of CSVD, the biomarkers of CSVD have been described as several categories related to sporadic and genetic factors. Monitoring of biomarkers might contribute to the early diagnosis and progression prediction of CSVD, thus providing ideas for better diagnosis and treatment of CSVD.https://www.frontiersin.org/articles/10.3389/fneur.2022.969185/fullcerebral small-vessel diseasebiomarkerblood-brain barrierwhite matter hyperintensitieslacunesenlarged perivascular spaces |
| spellingShingle | Xiaolu Liu Pei Sun Jing Yang Yuhua Fan Biomarkers involved in the pathogenesis of cerebral small-vessel disease Frontiers in Neurology cerebral small-vessel disease biomarker blood-brain barrier white matter hyperintensities lacunes enlarged perivascular spaces |
| title | Biomarkers involved in the pathogenesis of cerebral small-vessel disease |
| title_full | Biomarkers involved in the pathogenesis of cerebral small-vessel disease |
| title_fullStr | Biomarkers involved in the pathogenesis of cerebral small-vessel disease |
| title_full_unstemmed | Biomarkers involved in the pathogenesis of cerebral small-vessel disease |
| title_short | Biomarkers involved in the pathogenesis of cerebral small-vessel disease |
| title_sort | biomarkers involved in the pathogenesis of cerebral small vessel disease |
| topic | cerebral small-vessel disease biomarker blood-brain barrier white matter hyperintensities lacunes enlarged perivascular spaces |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.969185/full |
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