The Roles of Inflammasomes in Host Defense against <i>Mycobacterium tuberculosis</i>
<i>Mycobacterium tuberculosis</i> (MTB) infection is characterized by granulomatous lung lesions and systemic inflammatory responses during active disease. Inflammasome activation is involved in regulation of inflammation. Inflammasomes are multiprotein complexes serving a platform for a...
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| Format: | Article |
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MDPI AG
2021-01-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/10/2/120 |
| _version_ | 1797407702547169280 |
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| author | Jialu Ma Shasha Zhao Xiao Gao Rui Wang Juan Liu Xiangmei Zhou Yang Zhou |
| author_facet | Jialu Ma Shasha Zhao Xiao Gao Rui Wang Juan Liu Xiangmei Zhou Yang Zhou |
| author_sort | Jialu Ma |
| collection | DOAJ |
| description | <i>Mycobacterium tuberculosis</i> (MTB) infection is characterized by granulomatous lung lesions and systemic inflammatory responses during active disease. Inflammasome activation is involved in regulation of inflammation. Inflammasomes are multiprotein complexes serving a platform for activation of caspase-1, which cleaves the proinflammatory cytokines such as interleukin-1β (IL-1β) and IL-18 into their active forms. These cytokines play an essential role in MTB control. MTB infection triggers activation of the nucleotide-binding domain, leucine-rich-repeat containing family, pyrin domain-containing 3 (NLRP3) and absent in melanoma 2 (AIM2) inflammasomes in vitro, but only AIM2 and apoptosis-associated speck-like protein containing a caspase-activation recruitment domain (ASC), rather than NLRP3 or caspase-1, favor host survival and restriction of mycobacterial replication in vivo. Interferons (IFNs) inhibits MTB-induced inflammasome activation and IL-1 signaling. In this review, we focus on activation and regulation of the NLRP3 and AIM2 inflammasomes after exposure to MTB, as well as the effect of inflammasome activation on host defense against the infection. |
| first_indexed | 2024-03-09T03:45:22Z |
| format | Article |
| id | doaj.art-63c28fee66244b60931d5c1070cb5025 |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-09T03:45:22Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-63c28fee66244b60931d5c1070cb50252023-12-03T14:34:36ZengMDPI AGPathogens2076-08172021-01-0110212010.3390/pathogens10020120The Roles of Inflammasomes in Host Defense against <i>Mycobacterium tuberculosis</i>Jialu Ma0Shasha Zhao1Xiao Gao2Rui Wang3Juan Liu4Xiangmei Zhou5Yang Zhou6College of Veterinary Medicine, Southwest University, Chongqing 402460, ChinaCollege of Veterinary Medicine, Southwest University, Chongqing 402460, ChinaCollege of Veterinary Medicine, Southwest University, Chongqing 402460, ChinaCollege of Veterinary Medicine, Southwest University, Chongqing 402460, ChinaCollege of Veterinary Medicine, Southwest University, Chongqing 402460, ChinaState Key Laboratories for Agrobiotechnology, Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, National Animal Transmissible Spongiform Encephalopathy Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing 100193, ChinaCollege of Veterinary Medicine, Southwest University, Chongqing 402460, China<i>Mycobacterium tuberculosis</i> (MTB) infection is characterized by granulomatous lung lesions and systemic inflammatory responses during active disease. Inflammasome activation is involved in regulation of inflammation. Inflammasomes are multiprotein complexes serving a platform for activation of caspase-1, which cleaves the proinflammatory cytokines such as interleukin-1β (IL-1β) and IL-18 into their active forms. These cytokines play an essential role in MTB control. MTB infection triggers activation of the nucleotide-binding domain, leucine-rich-repeat containing family, pyrin domain-containing 3 (NLRP3) and absent in melanoma 2 (AIM2) inflammasomes in vitro, but only AIM2 and apoptosis-associated speck-like protein containing a caspase-activation recruitment domain (ASC), rather than NLRP3 or caspase-1, favor host survival and restriction of mycobacterial replication in vivo. Interferons (IFNs) inhibits MTB-induced inflammasome activation and IL-1 signaling. In this review, we focus on activation and regulation of the NLRP3 and AIM2 inflammasomes after exposure to MTB, as well as the effect of inflammasome activation on host defense against the infection.https://www.mdpi.com/2076-0817/10/2/120<i>Mycobacterium tuberculosis</i>inflammasomeNLRP3AIM2IFN |
| spellingShingle | Jialu Ma Shasha Zhao Xiao Gao Rui Wang Juan Liu Xiangmei Zhou Yang Zhou The Roles of Inflammasomes in Host Defense against <i>Mycobacterium tuberculosis</i> Pathogens <i>Mycobacterium tuberculosis</i> inflammasome NLRP3 AIM2 IFN |
| title | The Roles of Inflammasomes in Host Defense against <i>Mycobacterium tuberculosis</i> |
| title_full | The Roles of Inflammasomes in Host Defense against <i>Mycobacterium tuberculosis</i> |
| title_fullStr | The Roles of Inflammasomes in Host Defense against <i>Mycobacterium tuberculosis</i> |
| title_full_unstemmed | The Roles of Inflammasomes in Host Defense against <i>Mycobacterium tuberculosis</i> |
| title_short | The Roles of Inflammasomes in Host Defense against <i>Mycobacterium tuberculosis</i> |
| title_sort | roles of inflammasomes in host defense against i mycobacterium tuberculosis i |
| topic | <i>Mycobacterium tuberculosis</i> inflammasome NLRP3 AIM2 IFN |
| url | https://www.mdpi.com/2076-0817/10/2/120 |
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